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Open Access 01-12-2012 | Research article

Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment

Authors: Maria Del Ben, Mario Fabiani, Lorenzo Loffredo, Licia Polimeni, Roberto Carnevale, Francesco Baratta, Marco Brunori, Fabiana Albanese, Teresa Augelletti, Francesco Violi, Francesco Angelico

Published in: BMC Pulmonary Medicine | Issue 1/2012

Abstract

Background

Several studies suggest an increase of oxidative stress and a reduction of endothelial function in obstructive sleep apnoea syndrome (OSAS). We assessed the association between OSAS, endothelial dysfunction and oxidative stress. Further aim was to evaluate the effect of nasal continuous positive airway pressure (nCPAP) on oxidative stress and arterial dysfunction.

Methods

We studied 138 consecutive patients with heavy snoring and possible OSAS. Patients underwent unattended overnight home polysomnography. Ten patients with severe OSAS were revaluated after 6 months of nCPAP therapy. To assess oxidative stress in vivo, we measured urinary 8-iso-PGF2α and serum levels of soluble NOX2-derived peptide (sNOX2-dp). Serum levels of nitrite/nitrate (NOx) were also determined. Flow-mediated brachial artery dilation (FMD) was measured to asses endothelial function.

Results

Patients with severe OSAS had higher urinary 8-iso-PGF2α (p<0.001) and serum NOX2 and lower NOx. A negative association was observed between FMD and OSA severity. Apnea/hypopnea index was significantly correlated with the indices of central obesity and with urinary 8-isoprostanes (r=0.298, p<0.001). The metabolic syndrome (t=-4.63, p<0.001) and urinary 8-isoprostanes (t=-2.02, p<0.05) were the only independent predictors of FMD. After 6-months nCPAP treatment, a significant decrease of serum NOX2, (p<0.005) and urinary 8-iso-PGF2α (p<0.01) was observed, while serum NOx showed only a minor increase. A statistically significant increase of FMD was observed (from 3.6% to 7.0%).

Conclusions

The results of our study indicate that patients with OSAS and cardiometabolic comorbidities have increased oxidative stress and arterial dysfunction that are partially reversed by nCPAP treatment.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/12/36/prepub

Title: Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment
Authors: Maria Del Ben
Mario Fabiani
Lorenzo Loffredo
Licia Polimeni
Roberto Carnevale
Francesco Baratta
Marco Brunori
Fabiana Albanese
Teresa Augelletti
Francesco Violi
Francesco Angelico
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2012
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/1471-2466-12-36

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