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BMC Public Health
Published in: BMC Public Health 1/2008

Open Access 01-12-2008 | Research article

Assessment of measles immunity among infants in Maputo City, Mozambique

Authors: Jagrati V Jani, Carol Holm-Hansen, Tufária Mussá, Arlinda Zango, Ivan Manhiça, Gunnar Bjune, Ilesh V Jani

Published in: BMC Public Health | Issue 1/2008

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Abstract

Background

The optimum age for measles vaccination varies from country to country and thus a standardized vaccination schedule is controversial. While the increase in measles vaccination coverage has produced significant changes in the epidemiology of infection, vaccination schedules have not been adjusted. Instead, measures to cut wild-type virus transmission through mass vaccination campaigns have been instituted. This study estimates the presence of measles antibodies among six- and nine-month-old children and assesses the current vaccination seroconversion by using a non invasive method in Maputo City, Mozambique.

Methods

Six- and nine-month old children and their mothers were screened in a cross-sectional study for measles-specific antibodies in oral fluid. All vaccinated children were invited for a follow-up visit 15 days after immunization to assess seroconversion.

Results

82.4% of the children lost maternal antibodies by six months. Most children were antibody-positive post-vaccination at nine months, although 30.5 % of nine month old children had antibodies in oral fluid before vaccination. We suggest that these pre-vaccination antibodies are due to contact with wild-type of measles virus. The observed seroconversion rate after vaccination was 84.2%.

Conclusion

These data indicate a need to re-evaluate the effectiveness of the measles immunization policy in the current epidemiological scenario.
Literature
1.
Dodd R, Cassels A: Health, development and the Millennium Development Goals. Annals of tropical medicine and parasitology. 2006, 100 (5–6): 379-387. 10.1179/136485906X97471.CrossRefPubMed
2.
Moss WJ, Griffin DE: Global measles elimination. Nat Rev Microbiol. 2006, 4 (12): 900-908. 10.1038/nrmicro1550.CrossRefPubMed
3.
Cutts FT, Monteiro O, Tabard P, Cliff J: Measles control in Maputo, Mozambique, using a single dose of Schwarz vaccine at age 9 months. Bull World Health Organ. 1994, 72 (2): 227-231.PubMedPubMedCentral
4.
Jani JV, Jani IV, Araujo C, Sahay S, Barreto J, Bjune G: Assessment of routine surveillance data as a tool to investigate measles outbreaks in Mozambique. BMC Infect Dis. 2006, 6: 29-10.1186/1471-2334-6-29.CrossRefPubMedPubMedCentral
5.
Cliff J, Simango A, Augusto O, Paal Van Der L, Biellik R: Failure of targeted urban supplemental measles vaccination campaigns (1997–1999) to prevent measles epidemics in Mozambique (1998–2001). J Infect Dis. 2003, 187 (Suppl 1): S51-57. 10.1086/368058.CrossRefPubMed
6.
Coetzee N, Hussey GD, Visser G, Barron P, Keen A: The 1992 measles epidemic in Cape Town–a changing epidemiological pattern. S Afr Med J. 1994, 84 (3): 145-149.PubMed
7.
McLean AR: After the honeymoon in measles control. Lancet. 1995, 345 (8945): 272-10.1016/S0140-6736(95)90272-4.CrossRefPubMed
8.
Mulholland K: Measles and pertussis in developing countries with good vaccine coverage. Lancet. 1995, 345 (8945): 305-307. 10.1016/S0140-6736(95)90282-1.CrossRefPubMed
9.
Henao-Restrepo AM, Strebel P, John Hoekstra E, Birmingham M, Bilous J: Experience in global measles control, 1990–2001. J Infect Dis. 2003, 187 (Suppl 1): S15-21. 10.1086/368273.CrossRefPubMed
10.
Otten M, Kezaala R, Fall A, Masresha B, Martin R, Cairns L, Eggers R, Biellik R, Grabowsky M, Strebel P, et al: Public-health impact of accelerated measles control in the WHO African Region 2000–03. Lancet. 2005, 366 (9488): 832-839. 10.1016/S0140-6736(05)67216-9.CrossRefPubMed
11.
Otten MW, Okwo-Bele JM, Kezaala R, Biellik R, Eggers R, Nshimirimana D: Impact of alternative approaches to accelerated measles control: experience in the African region, 1996–2002. J Infect Dis. 2003, 187 (Suppl 1): S36-43. 10.1086/368272.CrossRefPubMed
12.
Tapia MD, Sow SO, Medina-Moreno S, Lim Y, Pasetti MF, Kotloff K, Levine MM: A serosurvey to identify the window of vulnerability to wild-type measles among infants in rural Mali. Am J Trop Med Hyg. 2005, 73 (1): 26-31.PubMed
13.
Dagan R, Slater PE, Duvdevani P, Golubev N, Mendelson E: Decay of maternally derived measles antibody in a highly vaccinated population in southern Israel. Pediatr Infect Dis J. 1995, 14 (11): 965-969.CrossRefPubMed
14.
Enquselassie F, Ayele W, Dejene A, Messele T, Abebe A, Cutts FT, Nokes DJ: Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination. Epidemiol Infect. 2003, 130 (3): 507-519.PubMedPubMedCentral
15.
George JR, Fitchen JH: Future applications of oral fluid specimen technology. Am J Med. 1997, 102 (4A): 21-25. 10.1016/S0002-9343(97)00034-X.CrossRefPubMed
16.
Nokes DJ, Enquselassie F, Nigatu W, Vyse AJ, Cohen BJ, Brown DW, Cutts FT: Has oral fluid the potential to replace serum for the evaluation of population immunity levels? A study of measles, rubella and hepatitis B in rural Ethiopia. Bull World Health Organ. 2001, 79 (7): 588-595.PubMedPubMedCentral
17.
Nigatu W, Nokes DJ, Cohen BJ, Brown DWG, Vyse AJ: Pre-and post-vaccine measles antibody status in infants using serum and oral-fluid testing: An evaluation of routine immunization in Addis Ababa, Ethiopia. Ethip J Health Dev. 2003, 17 (3): 149-155.
18.
Hutchins SS, Papania MJ, Amler R, Maes EF, Grabowsky M, Bromberg K, Glasglow V, Speed T, Bellini WJ, Orenstein WA: Evaluation of the measles clinical case definition. J Infect Dis. 2004, 189 (Suppl 1): S153-159. 10.1086/379652.CrossRefPubMed
19.
Cutts FT, Bartoloni A, Guglielmetti P, Gil F, Brown D, Bianchi Bandinelli ML, Roselli M: Prevalence of measles antibody among children under 15 years of age in Santa Cruz, Bolivia: implications for vaccination strategies. Trans R Soc Trop Med Hyg. 1995, 89 (1): 119-122. 10.1016/0035-9203(95)90683-5.CrossRefPubMed
20.
Nokes DJ, Enquselassie F, Vyse A, Nigatu W, Cutts FT, Brown DW: An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community. Trans R Soc Trop Med Hyg. 1998, 92 (6): 679-685. 10.1016/S0035-9203(98)90811-2.CrossRefPubMed
21.
Nigatu W, Nokes DJ, Enquselassie F, Brown DW, Cohen BJ, Vyse AJ, Cutts FT: Detection of measles specific IgG in oral fluid using an FITC/anti-FITC IgG capture enzyme linked immunosorbent assay (GACELISA). J Virol Methods. 1999, 83 (1–2): 135-144. 10.1016/S0166-0934(99)00116-0.CrossRefPubMed
22.
de Quadros CA, Olive JM, Hersh BS, Strassburg MA, Henderson DA, Brandling-Bennett D, Alleyne GA: Measles elimination in the Americas. Evolving strategies. Jama. 1996, 275 (3): 224-229. 10.1001/jama.275.3.224.CrossRefPubMed
23.
24.
Ratnam S, Gadag V, West R, Burris J, Oates E, Stead F, Bouilianne N: Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody. J Clin Microbiol. 1995, 33 (4): 811-815.PubMedPubMedCentral
25.
Ward BJ, Aouchiche S, Martel N, Bertley FM, Bautista-Lopez N, Serhir B, Ratnam S: Measurement of measles virus-specific neutralizing antibodies: evaluation of the syncytium inhibition assay in comparison with the plaque reduction neutralization test. Diagn Microbiol Infect Dis. 1999, 33 (3): 147-152. 10.1016/S0732-8893(98)00069-8.CrossRefPubMed
26.
Vardas E, Kreis S: Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual. J Clin Virol. 1999, 13 (3): 173-179. 10.1016/S1386-6532(99)00026-8.CrossRefPubMed
27.
Prasad SR, Shaikh NJ, Verma S, Banerjee K: IgG & IgM antibodies against measles virus in unvaccinated infants from Pune: evidence for subclinical infections. Indian J Med Res. 1995, 101: 1-5.PubMed
28.
Prista A, Maia JA, Damasceno A, Beunen G: Anthropometric indicators of nutritional status: implications for fitness, activity, and health in school-age children and adolescents from Maputo, Mozambique. The American journal of clinical nutrition. 2003, 77 (4): 952-959.PubMed
29.
Mongelli M, Wilcox M, Gardosi J: Estimating the date of confinement: ultrasonographic biometry versus certain menstrual dates. Am J Obstet Gynecol. 1996, 174 (1 Pt 1): 278-281. 10.1016/S0002-9378(96)70408-8.CrossRefPubMed
30.
Savitz DA, Terry JW, Dole N, Thorp JM, Siega-Riz AM, Herring AH: Comparison of pregnancy dating by last menstrual period, ultrasound scanning, and their combination. Am J Obstet Gynecol. 2002, 187 (6): 1660-1666. 10.1067/mob.2002.127601.CrossRefPubMed
31.
Lennon JL, Black FL: Maternally derived measles immunity in era of vaccine-protected mothers. J Pediatr. 1986, 108 (5 Pt 1): 671-676.CrossRefPubMed
32.
Jenks PJ, Caul EO, Roome AP: Maternally derived measles immunity in children of naturally infected and vaccinated mothers. Epidemiol Infect. 1988, 101 (2): 473-476.CrossRefPubMedPubMedCentral
33.
Kremer JR, Muller CP: Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees. Clin Diagn Lab Immunol. 2005, 12 (5): 668-670. 10.1128/CDLI.12.5.668-670.2005.PubMedPubMedCentral
34.
Hull HF, Williams PJ, Oldfield F: Measles mortality and vaccine efficacy in rural West Africa. Lancet. 1983, 1 (8331): 972-975. 10.1016/S0140-6736(83)92091-3.CrossRefPubMed
35.
Gans H, Yasukawa L, Rinki M, DeHovitz R, Forghani B, Beeler J, Audet S, Maldonado Y, Arvin AM: Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months. J Infect Dis. 2001, 184 (7): 817-826. 10.1086/323346.CrossRefPubMed
36.
Permar SR, Moss WJ, Ryon JJ, Monze M, Cutts F, Quinn TC, Griffin DE: Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. J Infect Dis. 2001, 183 (4): 532-538. 10.1086/318533.CrossRefPubMed
37.
Vainio K, Samdal HH, Anestad G, Wedege E, Skutlaberg DH, Bransdal KT, Mundal R, Aaberge IS: Detection of measles- and mumps-specific IgG antibodies in paired serum and oral fluid samples from Norwegian conscripts. Eur J Clin Microbiol Infect Dis. 2008, 27 (6): 461-465. 10.1007/s10096-008-0460-3.CrossRefPubMed
38.
Aaby P, Bukh J, Hoff G, Leerhoy J, Lisse IM, Mordhorst CH, Pedersen IR: High measles mortality in infancy related to intensity of exposure. J Pediatr. 1986, 109 (1): 40-44. 10.1016/S0022-3476(86)80569-8.CrossRefPubMed
Metadata
Title
Assessment of measles immunity among infants in Maputo City, Mozambique
Authors
Jagrati V Jani
Carol Holm-Hansen
Tufária Mussá
Arlinda Zango
Ivan Manhiça
Gunnar Bjune
Ilesh V Jani
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2008
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-8-386

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