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BMC Public Health
Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

Success rates with nicotine personal vaporizers: a prospective 6-month pilot study of smokers not intending to quit

Authors: Riccardo Polosa, Pasquale Caponnetto, Marilena Maglia, Jaymin B Morjaria, Cristina Russo

Published in: BMC Public Health | Issue 1/2014

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Abstract

Background

Electronic cigarettes (e-Cigs) are an attractive long-term alternative nicotine source to conventional cigarettes. Although they may assist smokers to remain abstinent during their quit attempt, studies using first generation e-Cigs report low success rates. Second generation devices (personal vaporisers - PVs) may result in much higher quit rates, but their efficacy and safety in smoking cessation and/or reduction in clinical trials is unreported.

Method

We conducted a prospective proof-of-concept study monitoring modifications in smoking behaviour of 50 smokers (unwilling to quit) switched onto PVs. Participants attended five study visits: baseline, week-4, week-8, week-12 and week-24. Number of cigarettes/day (cigs/day) and exhaled carbon monoxide (eCO) levels were noted at each visit. Smoking reduction/abstinence rates, product usage, adverse events and subjective opinions of these products were also reviewed.

Results

Sustained 50% and 80% reduction in cigs/day at week-24 was reported in 15/50 (30%) and 7/50 (14%) participants with a reduction from 25cigs/day to 6cigs/day (p < 0.001) and 3cigs/day (p < 0.001), respectively. Smoking abstinence (self-reported abstinence from cigarette smoking verified by an eCO ≤10 ppm) at week-24 was observed in 18/50 (36%) participants, with 15/18 (83.3%) still using their PVs at the end of the study. Combined 50% reduction and smoking abstinence was shown in 33/50 (66%) participants. Throat/mouth irritation (35.6%), dry throat/mouth (28.9%), headache (26.7%) and dry cough (22.2%) were frequently reported early in the study, but waned substantially by week-24. Participants’ perception and acceptance of the products was very good.

Conclusion

The use of second generation PVs substantially decreased cigarette consumption without causing significant adverse effects in smokers not intending to quit.

Trial registration

(ClinicalTrials.gov Identifier: NCT02124200)
Appendix
Available only for authorised users
Literature
1.
Buchhalter AR, Acosta MC, Evans SE, Breland AB, Eissenberg T: Tobacco abstinence symptom suppression: the role played by the smoking-related stimuli that are delivered by denicotinized cigarettes. Addiction. 2005, 100 (4): 550-559.CrossRefPubMed
2.
Hughes JR, Keely J, Naud S: Shape of the relapse curve and long-term abstinence among untreated smokers. Addiction. 2004, 99 (1): 29-38.CrossRefPubMed
3.
Polosa R, Benowitz NL: Treatment of nicotine addiction: present therapeutic options and pipeline developments. Trends Pharmacol Sci. 2011, 32 (5): 281-289.CrossRefPubMed
4.
Stead LF, Lancaster T: Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database Syst Rev. 2012, 10: CD008286-PubMed
5.
Apelberg BJ, Onicescu G, Avila-Tang E, Samet JM: Estimating the risks and benefits of nicotine replacement therapy for smoking cessation in the United States. Am J Public Health. 2010, 100 (2): 341-348.CrossRefPubMedPubMedCentral
6.
Casella G, Caponnetto P, Polosa R: Therapeutic advances in the treatment of nicotine addiction: present and future. Ther Adv Chronic Dis. 2010, 1 (3): 95-106.CrossRefPubMedPubMedCentral
7.
Alpert HR, Connolly GN, Biener L: A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation. Tob Control. 2013, 22 (1): 32-37.CrossRefPubMed
8.
Pierce JP, Cummins SE, White MM, Humphrey A, Messer K: Quitlines and nicotine replacement for smoking cessation: do we need to change policy?. Annu Rev Public Health. 2012, 33: 341-356.CrossRefPubMed
9.
Zhu SH, Lee M, Zhuang YL, Gamst A, Wolfson T: Interventions to increase smoking cessation at the population level: how much progress has been made in the last two decades?. Tob Control. 2012, 21 (2): 110-118.CrossRefPubMedPubMedCentral
10.
Caponnetto P, Campagna D, Papale G, Russo C, Polosa R: The emerging phenomenon of electronic cigarettes. Expert Rev Respir Med. 2012, 6 (1): 63-74.CrossRefPubMed
11.
Caponnetto P, Russo C, Bruno CM, Alamo A, Amaradio MD, Polosa R: Electronic cigarette: a possible substitute for cigarette dependence. Monaldi Arch Chest Dis. 2013, 79 (1): 12-19.PubMed
12.
Dawkins L, Turner J, Roberts A, Soar K: ‘Vaping’ profiles and preferences: an online survey of electronic cigarette users. Addiction. 2013, 108 (6): 1115-1125.CrossRefPubMed
13.
Etter JF, Bullen C: Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy. Addiction. 2011, 106 (11): 2017-2028.CrossRefPubMed
14.
Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M, Russo C, Polosa R: EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study. PLoS One. 2013, 8 (6): e66317-CrossRefPubMedPubMedCentral
15.
Bullen C, Howe C, Laugesen M, McRobbie H, Parag V, Williman J, Walker N: Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013, 382 (9905): 1629-1637.CrossRefPubMed
16.
Goniewicz ML, Kuma T, Gawron M, Knysak J, Kosmider L: Nicotine levels in electronic cigarettes. Nicotine Tob Res. 2013, 15 (1): 158-166.CrossRefPubMed
17.
Dawkins L, Corcoran O: Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology (Berl). 2014, 231 (2): 401-407.CrossRef
18.
Farsalinos KE, Spyrou A, Tsimopoulou K, Stefopoulos C, Romagna G, Voudris V: Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Sci Rep. 2014, 4: 4133-CrossRefPubMedPubMedCentral
19.
Fagerstrom KO, Schneider NG: Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire. J Behav Med. 1989, 12 (2): 159-182.CrossRefPubMed
20.
Beck A, Ward C, Mendelson M, Mock J, Erbaugh J: Manual for the Beck Depression Inventory. 1987, New York: Harcourt Brace Jovanovich
21.
Bolliger CT, Zellweger JP, Danielsson T, van Biljon X, Robidou A, Westin A, Perruchoud AP, Sawe U: Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety. BMJ. 2000, 321 (7257): 329-333.CrossRefPubMedPubMedCentral
22.
Polosa R, Caponnetto P, Morjaria JB, Papale G, Campagna D, Russo C: Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study. BMC Public Health. 2011, 11: 786-CrossRefPubMedPubMedCentral
23.
Smith SS, McCarthy DE, Japuntich SJ, Christiansen B, Piper ME, Jorenby DE, Fraser DL, Fiore MC, Baker TB, Jackson TC: Comparative effectiveness of 5 smoking cessation pharmacotherapies in primary care clinics. Arch Intern Med. 2009, 169 (22): 2148-2155.CrossRefPubMedPubMedCentral
24.
Polosa R, Caponnetto P: Advances in Smoking Cessation. 2013, London: Future Medicine, LtdCrossRef
25.
Wieslander G, Norback D, Lindgren T: Experimental exposure to propylene glycol mist in aviation emergency training: acute ocular and respiratory effects. Occup Environ Med. 2001, 58 (10): 649-655.CrossRefPubMedPubMedCentral
26.
Varughese S, Teschke K, Brauer M, Chow Y, van Netten C, Kennedy SM: Effects of theatrical smokes and fogs on respiratory health in the entertainment industry. Am J Ind Med. 2005, 47 (5): 411-418.CrossRefPubMed
27.
Fagerstrom KO, Hughes JR, Rasmussen T, Callas PW: Randomised trial investigating effect of a novel nicotine delivery device (Eclipse) and a nicotine oral inhaler on smoking behaviour, nicotine and carbon monoxide exposure, and motivation to quit. Tob Control. 2000, 9 (3): 327-333.CrossRefPubMedPubMedCentral
28.
Bullen C, McRobbie H, Thornley S, Glover M, Lin R, Laugesen M: Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tob Control. 2010, 19 (2): 98-103.CrossRefPubMed
29.
Nutt DJ, Phillips LD, Balfour D, Curran HV, Dockrell M, Foulds J, Fagerstrom K, Letlape K, Milton A, Polosa R, Ramsey J, Sweanor D: Estimating the Harms of Nicotine-Containing Products Using the MCDA Approach. Eur Addict Res. 2014, 20 (5): 218-225.CrossRefPubMed
30.
Farsalinos KE, Polosa R: Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarettes substitutes: A systematic review. Ther Adv Drug Saf. 2014, 5: 67-86.CrossRefPubMedPubMedCentral
31.
Farsalinos KE, Romagna G, Tsiapras D, Kyrzopoulos S, Voudris V: Evaluating nicotine levels selection and patterns of electronic cigarette use in a group of “vapers” who had achieved complete substitution of smoking. Subst Abuse. 2013, 7: 139-146.PubMedPubMedCentral
32.
Farsalinos KE, Romagna G, Tsiapras D, Kyrzopoulos S, Spyrou A, Voudris V: Impact of flavour variability on electronic cigarette use experience: an internet survey. Int J Environ Res Public Health. 2013, 10 (12): 7272-7282.CrossRefPubMedPubMedCentral
33.
Polosa R, Rodu B, Caponnetto P, Maglia M, Raciti C: A fresh look at tobacco harm reduction: the case for the electronic cigarette. Harm Reduct J. 2013, 10 (1): 19-CrossRefPubMedPubMedCentral
34.
Caponnetto P, Auditore R, Russo C, Cappello GC, Polosa R: Impact of an electronic cigarette on smoking reduction and cessation in schizophrenic smokers: a prospective 12-month pilot study. Int J Environ Res Public Health. 2013, 10 (2): 446-461.CrossRefPubMedPubMedCentral
35.
Polosa R, Morjaria JB, Caponnetto P, Caruso M, Strano S, Battaglia E, Russo C: Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal (in press). Int J Environ Res Public Health. 2014, 11 (5): 4965-4977.CrossRefPubMedPubMedCentral
36.
Metadata
Title
Success rates with nicotine personal vaporizers: a prospective 6-month pilot study of smokers not intending to quit
Authors
Riccardo Polosa
Pasquale Caponnetto
Marilena Maglia
Jaymin B Morjaria
Cristina Russo
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-1159

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