Skip to main content
Top
Published in: BMC Public Health 1/2012

Open Access 01-12-2012 | Research article

Predicting the outcome of a cognitive-behavioral group training for patients with unexplained physical symptoms: a one-year follow-up study

Authors: Lyonne NL Zonneveld, Yanda R van Rood, Cornelis G Kooiman, Reinier Timman, Adriaan van ’t Spijker, Jan JV Busschbach

Published in: BMC Public Health | Issue 1/2012

Login to get access

Abstract

Background

Although Cognitive-Behavioral Therapy (CBT) is effective for Unexplained Physical Symptoms (UPS), some therapists in clinical practice seem to believe that CBT outcome will diminish if psychiatric comorbidity is present. The result is that patients with a psychiatric comorbidity are redirected from treatment for UPS into treatment for mental health problems. To explore whether this selection and allocation are appropriate, we explored whether CBT outcomes in UPS could be predicted by variables assessed at baseline and used in routine-practice assessments.

Methods

Patients (n=162) with UPS classified as undifferentiated somatoform disorder or chronic pain disorder were followed up until one year after they had attended a CBT group training. The time-points of the follow-up were at the end of CBT (immediate outcome), three months after CBT (short-term outcome), and one year after CBT (long-term outcome).
CBT outcome was measured using the Physical Component Summary of the SF-36, which was the primary outcome measure in the randomized controlled trial that studied effectiveness of the CBT group training. Predictors were: 1.) psychological symptoms (global severity score of SCL-90), 2.) personality-disorder characteristics (sum of DSM-IV axis II criteria confirmed), 3.) psychiatric history (past presence of DSM-IV axis I disorders), and 4.) health-related quality of life in the mental domain (mental component summary of SF-36). The effect of this predictor set was explored using hierarchical multiple regression analyses into which these predictors had been entered simultaneously, after control for: a.) pretreatment primary outcome scores, b.) age, c.) gender, d.) marital status, and e.) employment.

Results

The predictor set was significant only for short-term CBT outcome, where it explained 15% of the variance. A better outcome was predicted by more psychological symptoms, fewer personality-disorder characteristics, the presence of a psychiatric history, and a better quality of life in the mental domain.

Conclusions

As the predictors do not seem to predict CBT outcome consistently over time, the need for selection and allocation of patients for CBT is doubtful. It seems that this would unnecessarily deprive patients of effective treatment.

Trial registration

Nederlands Trial Register, NTR1609
Appendix
Available only for authorised users
Literature
1.
go back to reference Kroenke K: Efficacy of treatment for somatoform disorders: a review of randomized controlled trials. Psychosom Med. 2007, 69 (9): 881-888. 10.1097/PSY.0b013e31815b00c4.CrossRefPubMed Kroenke K: Efficacy of treatment for somatoform disorders: a review of randomized controlled trials. Psychosom Med. 2007, 69 (9): 881-888. 10.1097/PSY.0b013e31815b00c4.CrossRefPubMed
2.
go back to reference Nezu AM, Nezu CM, Lombardo ER: Cognitive-behavior therapy for medically unexplained symptoms: a critical review of the treatment literature. Behav Ther. 2001, 32 (3): 537-583. 10.1016/S0005-7894(01)80035-6.CrossRef Nezu AM, Nezu CM, Lombardo ER: Cognitive-behavior therapy for medically unexplained symptoms: a critical review of the treatment literature. Behav Ther. 2001, 32 (3): 537-583. 10.1016/S0005-7894(01)80035-6.CrossRef
3.
go back to reference Sumathipala A: What is the evidence for the efficacy of treatments for somatoform disorders? A critical review of previous intervention studies. Psychosom Med. 2007, 69 (9): 889-900. 10.1097/PSY.0b013e31815b5cf6.CrossRefPubMed Sumathipala A: What is the evidence for the efficacy of treatments for somatoform disorders? A critical review of previous intervention studies. Psychosom Med. 2007, 69 (9): 889-900. 10.1097/PSY.0b013e31815b5cf6.CrossRefPubMed
4.
go back to reference Allen LA, Woolfolk RL, Escobar JI, Gara MA, Hamer RM: Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. Arch Intern Med. 2006, 166: 1512-1518. 10.1001/archinte.166.14.1512.CrossRefPubMed Allen LA, Woolfolk RL, Escobar JI, Gara MA, Hamer RM: Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. Arch Intern Med. 2006, 166: 1512-1518. 10.1001/archinte.166.14.1512.CrossRefPubMed
5.
go back to reference Allen LA, Woolfolk RL: Cognitive behavioral therapy for somatoform disorders. Psychiatr Clin North Am. 2010, 33: 579-593. 10.1016/j.psc.2010.04.014.CrossRefPubMed Allen LA, Woolfolk RL: Cognitive behavioral therapy for somatoform disorders. Psychiatr Clin North Am. 2010, 33: 579-593. 10.1016/j.psc.2010.04.014.CrossRefPubMed
6.
go back to reference Escobar JI, Gara MA, Diaz-Martinez AM, Interian A, Warman M, Allen LA, Woolfolk RL, Jahn E, Rodgers D: Effectiveness of a time-limited cognitive behavior therapy–type intervention among primary care patients with medically unexplained symptoms. Ann Fam Med. 2007, 5 (4): 328-335. 10.1370/afm.702.CrossRefPubMedPubMedCentral Escobar JI, Gara MA, Diaz-Martinez AM, Interian A, Warman M, Allen LA, Woolfolk RL, Jahn E, Rodgers D: Effectiveness of a time-limited cognitive behavior therapy–type intervention among primary care patients with medically unexplained symptoms. Ann Fam Med. 2007, 5 (4): 328-335. 10.1370/afm.702.CrossRefPubMedPubMedCentral
7.
go back to reference Greeven A, Van Balkom AJ, Van der Leeden R, Merkelbach JW, Van den Heuvel OA, Spinhoven P: Cognitive behavioral therapy versus paroxetine in the treatment of hypochondriasis: an 18-month naturalistic follow-up. J Behav Ther Exp Psychiatry. 2009, 40 (3): 487-496. 10.1016/j.jbtep.2009.06.005.CrossRefPubMed Greeven A, Van Balkom AJ, Van der Leeden R, Merkelbach JW, Van den Heuvel OA, Spinhoven P: Cognitive behavioral therapy versus paroxetine in the treatment of hypochondriasis: an 18-month naturalistic follow-up. J Behav Ther Exp Psychiatry. 2009, 40 (3): 487-496. 10.1016/j.jbtep.2009.06.005.CrossRefPubMed
8.
go back to reference Leibbrand R, Hiller W, Fichter MM: Effect of comorbid anxiety, depressive, and personality disorders on treatment outcome of somatoform disorders. Compr Psychiatry. 1999, 40 (3): 203-209. 10.1016/S0010-440X(99)90004-4.CrossRefPubMed Leibbrand R, Hiller W, Fichter MM: Effect of comorbid anxiety, depressive, and personality disorders on treatment outcome of somatoform disorders. Compr Psychiatry. 1999, 40 (3): 203-209. 10.1016/S0010-440X(99)90004-4.CrossRefPubMed
9.
go back to reference Rief W, Hiller W, Geissner E, Fichter MM: A two-year follow-up study of patients with somatoform disorders. Psychosomatics. 1995, 36 (4): 376-386. 10.1016/S0033-3182(95)71647-4.CrossRefPubMed Rief W, Hiller W, Geissner E, Fichter MM: A two-year follow-up study of patients with somatoform disorders. Psychosomatics. 1995, 36 (4): 376-386. 10.1016/S0033-3182(95)71647-4.CrossRefPubMed
10.
go back to reference Buwalda FM, Bouman TK: Predicting the effect of psychoeducational group treatment for hypochondriasis. Clin Psychol Psychother. 2008, 15: 396-403. 10.1002/cpp.602.CrossRefPubMed Buwalda FM, Bouman TK: Predicting the effect of psychoeducational group treatment for hypochondriasis. Clin Psychol Psychother. 2008, 15: 396-403. 10.1002/cpp.602.CrossRefPubMed
11.
go back to reference Kellner R: Prognosis of treated hypochondriasis. Acta Psychiatr Scand. 1983, 67: 69-79. 10.1111/j.1600-0447.1983.tb06725.x.CrossRefPubMed Kellner R: Prognosis of treated hypochondriasis. Acta Psychiatr Scand. 1983, 67: 69-79. 10.1111/j.1600-0447.1983.tb06725.x.CrossRefPubMed
12.
go back to reference Blanchard EB, Lackner JM, Gusmano R, Gudleski GD, Sanders K, Keefer L, Krasner S: Prediction of treatment outcome among patients with irritable bowel syndrome treated with group cognitive therapy. Behav Pharmacol. 2006, 44: 317-337. Blanchard EB, Lackner JM, Gusmano R, Gudleski GD, Sanders K, Keefer L, Krasner S: Prediction of treatment outcome among patients with irritable bowel syndrome treated with group cognitive therapy. Behav Pharmacol. 2006, 44: 317-337.
13.
go back to reference Shorter E, Abbey SE, Gillies LA, Singh M, Lipowski ZJ: Inpatient treatment of persistent somatization. Psychosomatics. 1992, 33 (3): 295-301. 10.1016/S0033-3182(92)71968-9.CrossRefPubMed Shorter E, Abbey SE, Gillies LA, Singh M, Lipowski ZJ: Inpatient treatment of persistent somatization. Psychosomatics. 1992, 33 (3): 295-301. 10.1016/S0033-3182(92)71968-9.CrossRefPubMed
14.
go back to reference Nakao M, Fricchione G, Myers P, Zuttermeister PC, Baim M, Mandle CL, Medich C, Wells-Federman CL, Arcari PM, Ennis M, et al: Anxiety is a good indicator for somatic symptom reduction through behavioral medicine intervention in a mind/body medicine clinic. Psychother Psychosom. 2001, 70: 50-57. 10.1159/000056225.CrossRefPubMed Nakao M, Fricchione G, Myers P, Zuttermeister PC, Baim M, Mandle CL, Medich C, Wells-Federman CL, Arcari PM, Ennis M, et al: Anxiety is a good indicator for somatic symptom reduction through behavioral medicine intervention in a mind/body medicine clinic. Psychother Psychosom. 2001, 70: 50-57. 10.1159/000056225.CrossRefPubMed
15.
go back to reference Bleichhardt G, Timmer B, Rief W: Prädiktoren für den direkten und längerfristigen therapieerfolg bei patienten mit somatoformen störungen nach verhaltenstherapeutischer behandlung. Z Klin Psychol Psychiatr Psychother. 2005, 53 (1): 40-58. Bleichhardt G, Timmer B, Rief W: Prädiktoren für den direkten und längerfristigen therapieerfolg bei patienten mit somatoformen störungen nach verhaltenstherapeutischer behandlung. Z Klin Psychol Psychiatr Psychother. 2005, 53 (1): 40-58.
16.
go back to reference Leibbrand R, Hiller W, Fichter MM: Influence of personality disorders on therapy outcome in somatoform disorders at 2-year follow-up. J Nerv Ment Dis. 1999, 187 (8): 509-512. 10.1097/00005053-199908000-00008.CrossRefPubMed Leibbrand R, Hiller W, Fichter MM: Influence of personality disorders on therapy outcome in somatoform disorders at 2-year follow-up. J Nerv Ment Dis. 1999, 187 (8): 509-512. 10.1097/00005053-199908000-00008.CrossRefPubMed
17.
go back to reference Hiller W, Leibbrand R, Rief W, Fichter MM: Predictors of course and outcome in hypochondriasis after cognitive-behavioural treatment. Psychother Psychosom. 2002, 71: 318-325. 10.1159/000065990.CrossRefPubMed Hiller W, Leibbrand R, Rief W, Fichter MM: Predictors of course and outcome in hypochondriasis after cognitive-behavioural treatment. Psychother Psychosom. 2002, 71: 318-325. 10.1159/000065990.CrossRefPubMed
18.
go back to reference Prins J, Bleijenberg G, Rouweler EK, Van der Meer J: Effect of psychiatric disorders on outcome of cognitive-behavioural therapy for chronic fatigue syndrome. Br J Psychiatry. 2005, 187: 184-185. 10.1192/bjp.187.2.184.CrossRefPubMed Prins J, Bleijenberg G, Rouweler EK, Van der Meer J: Effect of psychiatric disorders on outcome of cognitive-behavioural therapy for chronic fatigue syndrome. Br J Psychiatry. 2005, 187: 184-185. 10.1192/bjp.187.2.184.CrossRefPubMed
19.
go back to reference Deale A, Chalder T, Marks I, Wessely S: Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial. Am J Psychiatry. 1997, 154: 408-414.CrossRefPubMed Deale A, Chalder T, Marks I, Wessely S: Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial. Am J Psychiatry. 1997, 154: 408-414.CrossRefPubMed
20.
go back to reference Michaelson P, Sjölander P, Johansson H: Factors predicting pain reduction in chronic back and neck pain after multimodal treatment. Clin J Pain. 2004, 20 (6): 447-454. 10.1097/00002508-200411000-00010.CrossRefPubMed Michaelson P, Sjölander P, Johansson H: Factors predicting pain reduction in chronic back and neck pain after multimodal treatment. Clin J Pain. 2004, 20 (6): 447-454. 10.1097/00002508-200411000-00010.CrossRefPubMed
21.
go back to reference Bonner D, Ron M, Chalder T, Butler S, Wessely S: Chronic fatigue syndrome: a follow up study. J Neurol Neurosurg Psychiatry. 1994, 57: 617-621. 10.1136/jnnp.57.5.617.CrossRefPubMedPubMedCentral Bonner D, Ron M, Chalder T, Butler S, Wessely S: Chronic fatigue syndrome: a follow up study. J Neurol Neurosurg Psychiatry. 1994, 57: 617-621. 10.1136/jnnp.57.5.617.CrossRefPubMedPubMedCentral
22.
go back to reference Zonneveld LNL, Van Rood YR, Timman R, Kooiman CG, Vant Spijker A, Busschbach JJV: Effective group training for patients with unexplained physical symptoms: a randomized controlled trial with a non-randomized one-year follow-up. PLoS One. 2012, 7 (8): e42629-10.1371/journal.pone.0042629.CrossRefPubMedPubMedCentral Zonneveld LNL, Van Rood YR, Timman R, Kooiman CG, Vant Spijker A, Busschbach JJV: Effective group training for patients with unexplained physical symptoms: a randomized controlled trial with a non-randomized one-year follow-up. PLoS One. 2012, 7 (8): e42629-10.1371/journal.pone.0042629.CrossRefPubMedPubMedCentral
24.
go back to reference Zonneveld LNL, Van’t Spijker A, Passchier J, Van Busschbach JJ, Duivenvoorden HJ: he effectiveness of a training for patients with unexplained physical symptoms: protocol of a cognitive behavioral group training and randomized controlled trial. BMC Publ Health. 2009, 9: 251-10.1186/1471-2458-9-251.CrossRef Zonneveld LNL, Van’t Spijker A, Passchier J, Van Busschbach JJ, Duivenvoorden HJ: he effectiveness of a training for patients with unexplained physical symptoms: protocol of a cognitive behavioral group training and randomized controlled trial. BMC Publ Health. 2009, 9: 251-10.1186/1471-2458-9-251.CrossRef
25.
go back to reference De Waal MWM, Arnold IA, Eekhof JAH, Van Hemert AM: Somatoform disorders in general practice: prevalence, functional impairment and comorbidity with anxiety and depressive disorders. Br J Psychiatry. 2004, 184 (6): 470-476. 10.1192/bjp.184.6.470.CrossRefPubMed De Waal MWM, Arnold IA, Eekhof JAH, Van Hemert AM: Somatoform disorders in general practice: prevalence, functional impairment and comorbidity with anxiety and depressive disorders. Br J Psychiatry. 2004, 184 (6): 470-476. 10.1192/bjp.184.6.470.CrossRefPubMed
26.
go back to reference First MB, Spitzer RL, Gibbon M, Williams JBW: Structured clinical interview for DSM-IV axis I disorders. 1999, Amsterdam: Harcourt Test Publishers First MB, Spitzer RL, Gibbon M, Williams JBW: Structured clinical interview for DSM-IV axis I disorders. 1999, Amsterdam: Harcourt Test Publishers
27.
go back to reference Zonneveld LNL: Draaiboek ‘Omgaan met de gevolgen van onverklaarde lichamelijke klachten’. 2005, Vlaardingen/Rotterdam: Riagg Rijnmond/Erasmus MCDepartment of Medical Psychology and Psychotherapy, Zonneveld LNL: Draaiboek ‘Omgaan met de gevolgen van onverklaarde lichamelijke klachten’. 2005, Vlaardingen/Rotterdam: Riagg Rijnmond/Erasmus MCDepartment of Medical Psychology and Psychotherapy,
28.
go back to reference Zonneveld LNL, Duivenvoorden HJ, Passchier J, Van’t Spijker A: Tailoring a cognitive behavioural model for unexplained physical symptoms to patientcs perspective: a bottom-up approach. Clin Psychol Psychother. 2010, 17 (6): 528-535. 10.1002/cpp.685.CrossRefPubMed Zonneveld LNL, Duivenvoorden HJ, Passchier J, Van’t Spijker A: Tailoring a cognitive behavioural model for unexplained physical symptoms to patientcs perspective: a bottom-up approach. Clin Psychol Psychother. 2010, 17 (6): 528-535. 10.1002/cpp.685.CrossRefPubMed
29.
go back to reference Ware JE, Snow KK, Kosinski M, Gandek B: SF-36 health survey: manual and interpretation guide. 1993, Boston, MA: New England Medical Center, The HealthInstitute, Ware JE, Snow KK, Kosinski M, Gandek B: SF-36 health survey: manual and interpretation guide. 1993, Boston, MA: New England Medical Center, The HealthInstitute,
30.
go back to reference Zonneveld LNL, Van Rood YR, Timman R, Kooiman CG, Vant Spijker A, Busschbach JJV: Effective group training for patients with unexplained physical symptoms: a randomized controlled trial with a non-randomized one-year follow-up. PLoS One. 2012, e42629: 7-8. Zonneveld LNL, Van Rood YR, Timman R, Kooiman CG, Vant Spijker A, Busschbach JJV: Effective group training for patients with unexplained physical symptoms: a randomized controlled trial with a non-randomized one-year follow-up. PLoS One. 2012, e42629: 7-8.
31.
go back to reference Arrindell WA, Ettema JHM: SCL-90/symptom checklist: handleiding bij een multidimensionele psychopathologie-indicator. 2003, Lisse: Swets TestPublishers, Arrindell WA, Ettema JHM: SCL-90/symptom checklist: handleiding bij een multidimensionele psychopathologie-indicator. 2003, Lisse: Swets TestPublishers,
32.
go back to reference Duijsens IJ, Haringsma R, Eurelings-Bontekoe EHM: V.K.P. handleiding. 2002, Leiderdorp: Datec Duijsens IJ, Haringsma R, Eurelings-Bontekoe EHM: V.K.P. handleiding. 2002, Leiderdorp: Datec
33.
go back to reference Field A: Discovering statistics using SPSS. Regression. 2009, London:Sage, 197-263. 3, Field A: Discovering statistics using SPSS. Regression. 2009, London:Sage, 197-263. 3,
34.
go back to reference Miles JNV, Shevlin M: Applying regression and correlation: a guide for students and researchers. Issues in regression analysis. 2001, London: Sage, 119-121. Miles JNV, Shevlin M: Applying regression and correlation: a guide for students and researchers. Issues in regression analysis. 2001, London: Sage, 119-121.
35.
go back to reference Cohen J: Statistical power analysis for the behavioral sciences. 1988, Hillsdale, NewJersey: Lawrence Erlbaum, Cohen J: Statistical power analysis for the behavioral sciences. 1988, Hillsdale, NewJersey: Lawrence Erlbaum,
36.
go back to reference Heins MJ, Knoop H, Prins JB, Stulemeijer M, Van der Meer JWM, Bleijenberg G: Possible detrimental effects of cognitive behaviour therapy for chronic fatique syndrome. Psychother Psychosom. 2010, 79: 249-256. 10.1159/000315130.CrossRefPubMed Heins MJ, Knoop H, Prins JB, Stulemeijer M, Van der Meer JWM, Bleijenberg G: Possible detrimental effects of cognitive behaviour therapy for chronic fatique syndrome. Psychother Psychosom. 2010, 79: 249-256. 10.1159/000315130.CrossRefPubMed
38.
go back to reference Green SB: How many subjects does it take to do a regression-analysis. Multivar Behav Res. 1991, 26 (3): 499-510. 10.1207/s15327906mbr2603_7.CrossRef Green SB: How many subjects does it take to do a regression-analysis. Multivar Behav Res. 1991, 26 (3): 499-510. 10.1207/s15327906mbr2603_7.CrossRef
39.
go back to reference Pallant J: SPSS survival manual: a step by step guide to data analysis using SPSS for Windows (Version 12). 2005, Maidenhead Berkshire: OpenUniversity Press, 2, Pallant J: SPSS survival manual: a step by step guide to data analysis using SPSS for Windows (Version 12). 2005, Maidenhead Berkshire: OpenUniversity Press, 2,
40.
go back to reference Lambert MJ, Barley DE: Research summary on the therapeutic relationship and psychotherapy outcome. Psychotherapy: theory, research, practice training. 2001, 38 (4): 357-361.CrossRef Lambert MJ, Barley DE: Research summary on the therapeutic relationship and psychotherapy outcome. Psychotherapy: theory, research, practice training. 2001, 38 (4): 357-361.CrossRef
41.
go back to reference Nater UM, Jones JF, Lin J-MS, Maloney E, Reeves WC, Heim C: Personality features and personality disorders in chronic fatigue syndrome: a population-based study. Psychother Psychosom. 2010, 79: 312-318. 10.1159/000319312.CrossRefPubMedPubMedCentral Nater UM, Jones JF, Lin J-MS, Maloney E, Reeves WC, Heim C: Personality features and personality disorders in chronic fatigue syndrome: a population-based study. Psychother Psychosom. 2010, 79: 312-318. 10.1159/000319312.CrossRefPubMedPubMedCentral
42.
go back to reference Henningsen P, Zimmermann T, Sattel H: Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom Med. 2003, 65: 528-533. 10.1097/01.PSY.0000075977.90337.E7.CrossRefPubMed Henningsen P, Zimmermann T, Sattel H: Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom Med. 2003, 65: 528-533. 10.1097/01.PSY.0000075977.90337.E7.CrossRefPubMed
43.
go back to reference Peters S, Rogers A, Salmon P, Gask L, Dowrick C, Towey M, Clifford R, Morriss R: What do patients choose to tell their doctors? Qualitative analysis of potential barriers to reattributing medically unexplained symptoms. J Gen Intern Med. 2008, 24 (4): 443-449.CrossRefPubMedPubMedCentral Peters S, Rogers A, Salmon P, Gask L, Dowrick C, Towey M, Clifford R, Morriss R: What do patients choose to tell their doctors? Qualitative analysis of potential barriers to reattributing medically unexplained symptoms. J Gen Intern Med. 2008, 24 (4): 443-449.CrossRefPubMedPubMedCentral
44.
go back to reference Raine R, Haines A, Sensky T, Hutchings A, Larkin K, Black N: Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?. Br Med J. 2002, 325: 1082-1092. 10.1136/bmj.325.7372.1082.CrossRef Raine R, Haines A, Sensky T, Hutchings A, Larkin K, Black N: Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?. Br Med J. 2002, 325: 1082-1092. 10.1136/bmj.325.7372.1082.CrossRef
Metadata
Title
Predicting the outcome of a cognitive-behavioral group training for patients with unexplained physical symptoms: a one-year follow-up study
Authors
Lyonne NL Zonneveld
Yanda R van Rood
Cornelis G Kooiman
Reinier Timman
Adriaan van ’t Spijker
Jan JV Busschbach
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2012
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-12-848

Other articles of this Issue 1/2012

BMC Public Health 1/2012 Go to the issue