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BMC Public Health
Published in: BMC Public Health 1/2011

Open Access 01-12-2011 | Study protocol

Study protocol of KLIMOP: a cohort study on the wellbeing of older cancer patients in Belgium and the Netherlands

Authors: Laura Deckx, Doris van Abbema, Katherine Nelissen, Liesbeth Daniels, Piet Stinissen, Paul Bulens, Loes Linsen, Jean-Luc Rummens, Geert Robaeys, Eric T de Jonge, Bert Houben, Karin Pat, Daan Walgraeve, Luc Spaas, Jolanda Verheezen, Thessa Verniest, Alexander Goegebuer, Hans Wildiers, Franchette van den Berkmortel, Vivianne C Tjan-Heijnen, Frank Buntinx, Marjan van den Akker

Published in: BMC Public Health | Issue 1/2011

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Abstract

Background

Cancer is mainly a disease of older patients. In older cancer patients, additional endpoints such as quality of survival and daily functioning might be considered equally relevant as overall or disease free survival. However, these factors have been understudied using prospective designs focussing on older cancer patients. Therefore, this study will focus on the impact of cancer, ageing, and their interaction on the long-term wellbeing of older cancer patients.

Methods/Design

This study is an observational cohort study. We aim to recruit 720 cancer patients above 70 years with a new diagnosis of breast, prostate, lung or gastrointestinal cancer and two control groups: one control group of 720 patients above 70 years without a previous diagnosis of cancer and one control group of 720 cancer patients between 50 - 69 years newly diagnosed with breast, prostate, lung or gastrointestinal cancer. Data collection will take place at inclusion, after six months, after one year and every subsequent year until death or end of the study. Data will be collected through personal interviews (consisting of socio-demographic information, general health information, a comprehensive geriatric assessment, quality of life, health locus of control and a loneliness scale), a handgrip test, assessment of medical records, two buccal swabs and a blood sample from cancer patients (at baseline). As an annex study, caregivers of the participants will be recruited as well. Data collection for caregivers will consist of a self-administered questionnaire examining depression, coping, and burden.

Discussion

This extensive data collection will increase insight on how wellbeing of older cancer patients is affected by cancer (diagnosis and treatment), ageing, and their interaction. Results may provide new insights, which might contribute to the improvement of care for older cancer patients.
Appendix
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Literature
1.
Avis NE, Deimling GT: Cancer survivorship and aging. Cancer. 2008, 113: 3519-3529. 10.1002/cncr.23941.CrossRefPubMed
2.
Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007, 18: 581-592.CrossRefPubMed
3.
Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999, 341: 2061-2067. 10.1056/NEJM199912303412706.CrossRefPubMed
4.
Brunello A, Loaldi E, Balducci L: Dose adjustment and supportive care before and during treatment. Cancer Treat Rev. 2009, 35: 493-498. 10.1016/j.ctrv.2009.04.009.CrossRefPubMed
5.
Hurria A, Cohen HJ, Extermann M: Geriatric oncology research in the cooperative groups: A report of a SIOG special meeting. Journal of Geriatric Oncology. 2010, 1: 40-44. 10.1016/j.jgo.2010.03.005.CrossRefPubMedPubMedCentral
6.
Rodin MB, Mohile SG: A practical approach to geriatric assessment in oncology. J Clin Oncol. 2007, 25: 1936-1944. 10.1200/JCO.2006.10.2954.CrossRefPubMed
7.
Balducci L, Colloca G, Cesari M, Gambassi G: Assessment and treatment of elderly patients with cancer. Surg Oncol. 2010, 19: 117-123. 10.1016/j.suronc.2009.11.008.CrossRefPubMed
8.
Extermann M, Hurria A: Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2007, 25: 1824-1831. 10.1200/JCO.2007.10.6559.CrossRefPubMed
9.
Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, Mor V, Monfardini S, Repetto L, Sorbye L, Topinkova E: Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005, 55: 241-252. 10.1016/j.critrevonc.2005.06.003.CrossRefPubMed
10.
Overcash JA, Beckstead J, Moody L, Extermann M, Cobb S: The abbreviated comprehensive geriatric assessment (aCGA) for use in the older cancer patient as a prescreen: scoring and interpretation. Crit Rev Oncol Hematol. 2006, 59: 205-210. 10.1016/j.critrevonc.2006.04.003.CrossRefPubMed
11.
Saliba D, Elliott M, Rubenstein LZ, Solomon DH, Young RT, Kamberg CJ, Roth C, MacLean CH, Shekelle PG, Sloss EM, Wenger NS: The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc. 2001, 49: 1691-1699. 10.1046/j.1532-5415.2001.49281.x.CrossRefPubMed
12.
Steverink N, Slaets JPJ, Schuurmans H, van Lis M: Measuring frailty: development and testing of the Groningen Frailty Indicator (GFI). The Gerontologist. 2001, 41: 236-237.
13.
Soubeyran P, Bellera C, Goyard J, Heitz D, Cure H, Rousselot H, Albrand G, Servent V, Saint Jean O, Roy C, Mathoulin-Pelissier S, Rainfray M: Validation of the G8 screening tool in geriatric oncology: The ONCODAGE project. ASCO Annual Meeting 2011; Chicago. 2011, 9001-Journal of Clinical Oncology
14.
Pallis AG, Ring A, Fortpied C, Penninckx B, Van Nes MC, Wedding U, Vonminckwitz G, Johnson CD, Wyld L, Timmer-Bonte A, Bonnetain F, Repetto L, Aapro M, Luciani A, Wildiers H: EORTC workshop on clinical trial methodology in older individuals with a diagnosis of solid tumors. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO. 2011, 22: 1922-1926. 10.1093/annonc/mdq687.CrossRef
15.
von Zglinicki T, Martin-Ruiz CM: Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med. 2005, 5: 197-203. 10.2174/1566524053586545.CrossRefPubMed
16.
Bekaert S, De Meyer T, Van Oostveldt P: Telomere attrition as ageing biomarker. Anticancer Res. 2005, 25: 3011-3021.PubMed
17.
Mather KA, Jorm AF, Parslow RA, Christensen H: Is telomere length a biomarker of aging? A review. J Gerontol A Biol Sci Med Sci. 2011, 66: 202-213.CrossRefPubMed
18.
Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M, Segers P, Cooman L, Van Damme P, Cassiman P, Van Criekinge W, Verdonck P, De Backer GG, Gillebert TC, Van Oostveldt P: Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell. 2007, 6: 639-647. 10.1111/j.1474-9726.2007.00321.x.CrossRefPubMed
19.
Mather KA, Jorm AF, Milburn PJ, Tan X, Easteal S, Christensen H: No associations between telomere length and age-sensitive indicators of physical function in mid and later life. J Gerontol A Biol Sci Med Sci. 2010, 65: 792-799.CrossRefPubMed
20.
Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RG: Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell. 2005, 4: 287-290. 10.1111/j.1474-9726.2005.00171.x.CrossRefPubMed
21.
Harris SE, Deary IJ, MacIntyre A, Lamb KJ, Radhakrishnan K, Starr JM, Whalley LJ, Shiels PG: The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci Lett. 2006, 406: 260-264. 10.1016/j.neulet.2006.07.055.CrossRefPubMed
22.
Murasko DM, Nelson BJ, Silver R, Matour D, Kaye D: Immunologic response in an elderly population with a mean age of 85. Am J Med. 1986, 81: 612-618. 10.1016/0002-9343(86)90546-2.CrossRefPubMed
23.
Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M: The immune system in extreme longevity. Exp Gerontol. 2008, 43: 61-65. 10.1016/j.exger.2007.06.008.CrossRefPubMed
24.
Franceschi C, Monti D, Barbieri D, Grassilli E, Troiano L, Salvioli S, Negro P, Capri M, Guido M, Azzi R, et al: Immunosenescence in humans: deterioration or remodelling?. Int Rev Immunol. 1995, 12: 57-74. 10.3109/08830189509056702.CrossRefPubMed
25.
Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG: Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev. 1998, 102: 187-198. 10.1016/S0047-6374(97)00151-6.CrossRefPubMed
26.
Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG: Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000, 121: 187-201.CrossRefPubMed
27.
Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F: Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002, 37: 445-453. 10.1016/S0531-5565(01)00212-1.CrossRefPubMed
28.
Given B, Sherwood PR: Family care for the older person with cancer. Semin Oncol Nurs. 2006, 22: 43-50. 10.1016/j.soncn.2005.10.006.CrossRefPubMed
29.
Schoenmakers B, Buntinx F, De Lepeleire J: The relation between care giving and the mental health of caregivers of demented relatives: a cross-sectional study. Eur J Gen Pract. 2009, 15: 99-106. 10.1080/13814780903064455.CrossRefPubMed
30.
Schoenmakers B, Buntinx F, Delepeleire J: Factors determining the impact of care-giving on caregivers of elderly patients with dementia. A systematic literature review. Maturitas. 2010, 66: 191-200. 10.1016/j.maturitas.2010.02.009.CrossRefPubMed
31.
Weinberger MI, Roth AJ, Nelson CJ: Untangling the complexities of depression diagnosis in older cancer patients. Oncologist. 2009, 14: 60-66. 10.1634/theoncologist.2008-0147.CrossRefPubMedPubMedCentral
32.
Cohen M, Reuben D, Naeim A: Assessing the Older Cancer Patient. Geriatric Oncology. Edited by: Hurria A, Balducci L. 2009, Springer US, 17-45.CrossRef
33.
Vaes B, Pasquet A, Wallemacq P, Rezzoug N, Mekouar H, Olivier PA, Legrand D, Mathei C, Van Pottelbergh G, Degryse J: The BELFRAIL (BFC80+) study: a population-based prospective cohort study of the very elderly in Belgium. BMC Geriatr. 2010, 10: 39-10.1186/1471-2318-10-39.CrossRefPubMedPubMedCentral
34.
Rivera HR: Depression symptoms in cancer caregivers. Clin J Oncol Nurs. 2009, 13: 195-202. 10.1188/09.CJON.195.202.CrossRefPubMed
35.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008, 61: 344-349. 10.1016/j.jclinepi.2007.11.008.CrossRef
36.
Pallis AG, Fortpied C, Wedding U, Van Nes MC, Penninckx B, Ring A, Lacombe D, Monfardini S, Scalliet P, Wildiers H: EORTC elderly task force position paper: approach to the older cancer patient. Eur J Cancer. 2010, 46: 1502-1513. 10.1016/j.ejca.2010.02.022.CrossRefPubMed
37.
Hurria A, Balducci L: Aging and Cancer: What Oncologists Need to Know. Geriatric Oncology. Edited by: Hurria A, Balducci L. 2009, New York: Springer US, 1-15.CrossRef
38.
Puts MT, Monette J, Girre V, Wolfson C, Monette M, Batist G, Bergman H: Does frailty predict hospitalization, emergency department visits, and visits to the general practitioner in older newly-diagnosed cancer patients? Results of a prospective pilot study. Crit Rev Oncol Hematol. 2010, 76: 142-151. 10.1016/j.critrevonc.2009.10.006.CrossRefPubMed
39.
Minisini AM, De Faccio S, Ermacora P, Andreetta C, Fantinel R, Balestrieri M, Piga A, Puglisi F: Cognitive functions and elderly cancer patients receiving anticancer treatment: a prospective study. Crit Rev Oncol Hematol. 2008, 67: 71-79. 10.1016/j.critrevonc.2008.02.004.CrossRefPubMed
40.
Marinello R, Marenco D, Roglia D, Stasi MF, Ferrando A, Ceccarelli M, Bertetto O, Molaschi M, Ciccone G: Predictors of treatment failures during chemotherapy: A prospective study on 110 older cancer patients. Arch Gerontol Geriatr. 2009, 48: 222-226. 10.1016/j.archger.2008.01.011.CrossRefPubMed
41.
Mahoney FI, Barthel DW: Functional Evaluation: The Barthel Index. Md State Med J. 1965, 14: 61-65.PubMed
42.
Collin C, Wade DT, Davies S, Horne V: The Barthel ADL Index: a reliability study. Int Disabil Stud. 1988, 10: 61-63. 10.3109/09638288809164103.CrossRefPubMed
43.
Lawton MP, Brody EM: Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969, 9: 179-186. 10.1093/geront/9.3_Part_1.179.CrossRefPubMed
44.
Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO: Development and validation of a geriatric depression screening scale: a preliminary report. Journal of psychiatric research. 1982, 17: 37-49. 10.1016/0022-3956(82)90033-4.CrossRefPubMed
45.
Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975, 12: 189-198. 10.1016/0022-3956(75)90026-6.CrossRefPubMed
46.
De Jong-Gierveld J, Kamphuis F: The Development of a Rasch-Type Loneliness Scale. Applied Psychological Measurement. 1985, 9: 289-299. 10.1177/014662168500900307.CrossRef
47.
Overcash JA, Beckstead J, Extermann M, Cobb S: The abbreviated comprehensive geriatric assessment (aCGA): a retrospective analysis. Crit Rev Oncol Hematol. 2005, 54: 129-136. 10.1016/j.critrevonc.2004.12.002.CrossRefPubMed
48.
Coates A, Porzsolt F, Osoba D: Quality of life in oncology practice: prognostic value of EORTC QLQ-C30 scores in patients with advanced malignancy. Eur J Cancer. 1997, 33: 1025-1030. 10.1016/S0959-8049(97)00049-X.CrossRefPubMed
49.
Bauwens S, Baillon C, Distelmans W, Theuns P: The 'Distress Barometer': validation of method of combining the Distress Thermometer with a rated complaint scale. Psychooncology. 2009, 18: 534-542. 10.1002/pon.1425.CrossRefPubMed
50.
Sanderman R, Ormel J: De Utrechtse Coping Lijst (UCL): validiteit en betrouwbaarheid [The Utrecht Coping List (UCL): validity and precision]. Gedrag en Gezondheid. 1992, 20: 32-37.
51.
Halfens RJ: Een gezondheidsspecifieke beheersingsorientatieschaal validiteit en betrouwbaarheid van de MHLC. T Soc Gezondheidsz. 1988, 66: 399-403.
52.
Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40: 373-383. 10.1016/0021-9681(87)90171-8.CrossRefPubMed
53.
Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. The British journal of psychiatry: the journal of mental science. 1982, 140: 566-572. 10.1192/bjp.140.6.566.CrossRef
Metadata
Title
Study protocol of KLIMOP: a cohort study on the wellbeing of older cancer patients in Belgium and the Netherlands
Authors
Laura Deckx
Doris van Abbema
Katherine Nelissen
Liesbeth Daniels
Piet Stinissen
Paul Bulens
Loes Linsen
Jean-Luc Rummens
Geert Robaeys
Eric T de Jonge
Bert Houben
Karin Pat
Daan Walgraeve
Luc Spaas
Jolanda Verheezen
Thessa Verniest
Alexander Goegebuer
Hans Wildiers
Franchette van den Berkmortel
Vivianne C Tjan-Heijnen
Frank Buntinx
Marjan van den Akker
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2011
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-11-825

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