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BMC Psychiatry

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Open Access 01-12-2014 | Case report

Monitoring candidate gene expression variations before, during and after a first major depressive episode in a 51-year-old man

Authors: Raoul Belzeaux, Jean-Michel Azorin, El Chérif Ibrahim

Published in: BMC Psychiatry | Issue 1/2014

Abstract

Background

Although psychiatric disorders are frequently characterized by clinical heterogeneity, high recurrence, and unpredictable prognosis, studies of mRNA expression variations in blood cells from psychiatric patients constitute a promising avenue to establish clinical biomarkers. We report here, to our knowledge, the first genetic monitoring of a major depressive episode (MDE).

Case presentation

The subject is a 51-year-old male, who was healthy at baseline and whose blood mRNA was monitored over 67 weeks for expression variations of 9 candidate genes. At week 20 the subject experienced a mild to moderate unexpected MDE, and oral antidepressant treatment was initiated at week 29. At week 36, the patient recovered from his MDE. After 6 months, antidepressant treatment was discontinued and the subject remained free of depressive symptoms. Genetic monitoring revealed that mRNA expression of SLC6A4/5HTT increased with the emergence of a depressive state, which later returned to basal levels after antidepressant treatment and during MDE recovery. PDLIM5, S100A10 and TNF mRNA showed also an interesting pattern of expression with regards to MDE evolution.

Conclusion

This case demonstrated the applicability of peripheral mRNA expression as a way to monitor the natural history of MDE.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/14/73/prepub

Title: Monitoring candidate gene expression variations before, during and after a first major depressive episode in a 51-year-old man
Authors: Raoul Belzeaux
Jean-Michel Azorin
El Chérif Ibrahim
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/1471-244X-14-73

ACC 2024 Congress

Springer Medicine

Monitoring candidate gene expression variations before, during and after a first major depressive episode in a 51-year-old man

Abstract

Background

Case presentation

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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