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BMC Psychiatry
Published in: BMC Psychiatry 1/2013

Open Access 01-12-2013 | Research article

Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158Met genotype

Authors: Baer Arts, Claudia JP Simons, Marjan Drukker, Jim van Os

Published in: BMC Psychiatry | Issue 1/2013

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Abstract

Background

There is a negative association between the use of antipsychotics and cognitive functioning in bipolar patients, which may be mediated by altered dopamine signaling in selected brain areas, and moderation thereof by genetic sequence variation such as COMT Val108/158Met. The interaction between antipsychotic drug use and the COMT Val108/158Met genotype on two-year cognitive functioning in bipolar patients was examined.

Methods

Interaction between the COMT Val108/158Met and antipsychotics on a composite cognitive measure was examined in 51 bipolar patients who were assessed 12 times at two-monthly intervals over a period of two years (379 observations).

Results

There was a significant negative effect of the interaction between antipsychotic medications and Val allele load on the composite cognitive measure in bipolar patients (p < 0.001).

Conclusions

The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load. If replicated, the results may be indicative of pharmacogenetic interactions in bipolar disorder.
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Metadata
Title
Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158Met genotype
Authors
Baer Arts
Claudia JP Simons
Marjan Drukker
Jim van Os
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2013
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-13-63

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