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BMC Psychiatry
Published in: BMC Psychiatry 1/2013

Open Access 01-12-2013 | Study protocol

Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT)

Authors: Cindy C Hagan, Julia ME Graham, Barry Widmer, Rosemary J Holt, Cinly Ooi, Adrienne O van Nieuwenhuizen, Peter Fonagy, Shirley Reynolds, Mary Target, Raphael Kelvin, Paul O Wilkinson, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian Goodyer, John Suckling

Published in: BMC Psychiatry | Issue 1/2013

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Abstract

Background

Major depressive disorders (MDD) are a debilitating and pervasive group of mental illnesses afflicting many millions of people resulting in the loss of 110 million working days and more than 2,500 suicides per annum. Adolescent MDD patients attending NHS clinics show high rates of recurrence into adult life. A meta-analysis of recent research shows that psychological treatments are not as efficacious as previously thought. Modest treatment outcomes of approximately 65% of cases responding suggest that aetiological and clinical heterogeneity may hamper the better use of existing therapies and discovery of more effective treatments. Information with respect to optimal treatment choice for individuals is lacking, with no validated biomarkers to aid therapeutic decision-making.

Methods/Design

Magnetic resonance-Improving Mood with Psychoanalytic and Cognitive Therapies, the MR-IMPACT study, plans to identify brain regions implicated in the pathophysiology of depressions and examine whether there are specific behavioural or neural markers predicting remission and/or subsequent relapse in a subsample of depressed adolescents recruited to the IMPACT randomised controlled trial (Registration # ISRCTN83033550).

Discussion

MR-IMPACT is an investigative biomarker component of the IMPACT pragmatic effectiveness trial. The aim of this investigation is to identify neural markers and regional indicators of the pathophysiology of and treatment response for MDD in adolescents. We anticipate that these data may enable more targeted treatment delivery by identifying those patients who may be optimal candidates for therapeutic response.

Trial registration

Adjunctive study to IMPACT trial (Current Controlled Trials: ISRCTN83033550).
Appendix
Available only for authorised users
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Metadata
Title
Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT)
Authors
Cindy C Hagan
Julia ME Graham
Barry Widmer
Rosemary J Holt
Cinly Ooi
Adrienne O van Nieuwenhuizen
Peter Fonagy
Shirley Reynolds
Mary Target
Raphael Kelvin
Paul O Wilkinson
Edward T Bullmore
Belinda R Lennox
Barbara J Sahakian
Ian Goodyer
John Suckling
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2013
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-13-247

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