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Open Access 01-12-2011 | Research article

Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study

Authors: Samantha J Brooks, Gareth J Barker, Owen G O'Daly, Michael Brammer, Steven CR Williams, Christian Benedict, Helgi B Schiöth, Janet Treasure, Iain C Campbell

Published in: BMC Psychiatry | Issue 1/2011

Abstract

Background

Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume.

Methods

Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN) and 21 women (HC) was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS).

Results

Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN.

Conclusions

In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/11/179/prepub

Title: Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study
Authors: Samantha J Brooks
Gareth J Barker
Owen G O'Daly
Michael Brammer
Steven CR Williams
Christian Benedict
Helgi B Schiöth
Janet Treasure
Iain C Campbell
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2011
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/1471-244X-11-179

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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