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BMC Pediatrics
Published in: BMC Pediatrics 1/2004

Open Access 01-12-2004 | Research article

Low birth weight and longitudinal trends of cardiovascular risk factor variables from childhood to adolescence: the bogalusa heart study

Authors: Maria G Frontini, Sathanur R Srinivasan, Jihua Xu, Gerald S Berenson

Published in: BMC Pediatrics | Issue 1/2004

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Abstract

Background

Several studies have linked low birth weight to adverse levels of cardiovascular risk factors and related diseases. However, information is sparse at a community level in the U.S. general population regarding the effects of low birth weight on the longitudinal trends in cardiovascular risk factor variables measured concurrently from childhood to adolescence.

Methods

Longitudinal analysis was performed retrospectively on data collected from the Bogalusa Heart Study cohort (n = 1141; 57% white, 43% black) followed from childhood to adolescence by repeated surveys between 1973 and 1996. Subjects were categorized into low birth weight (below the race-specific 10th percentile; n = 123) and control (between race-specific 50–75th percentile; n = 296) groups.

Results

Low birth weight group vs control group had lower mean HDL cholesterol (p = 0.05) and higher LDL cholesterol (p = 0.05) during childhood (ages 4–11 years); higher glucose (p = 0.02) during adolescence. Yearly rates of change from childhood to adolescence in systolic blood pressure (p = 0.02), LDL cholesterol (p = 0.05), and glucose (p = 0.07) were faster, and body mass index (p = 0.03) slower among the low birth weight group. In a multivariate analysis, low birth weight was related independently and adversely to longitudinal trends in systolic blood pressure (p = 0.004), triglycerides (p = 0.03), and glucose (p = 0.07), regardless of race or gender. These adverse associations became amplified with age.

Conclusions

Low birth weight is characterized by adverse developmental trends in metabolic and hemodynamic variables during childhood and adolescence; and thus, it may be an early risk factor in this regard.
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Metadata
Title
Low birth weight and longitudinal trends of cardiovascular risk factor variables from childhood to adolescence: the bogalusa heart study
Authors
Maria G Frontini
Sathanur R Srinivasan
Jihua Xu
Gerald S Berenson
Publication date
01-12-2004
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2004
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/1471-2431-4-22

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