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BMC Cancer

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Open Access 01-12-2014 | Research article

ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer

Authors: Xiao-shan Li, Qing Xu, Xiang-yang Fu, Wei-sheng Luo

Published in: BMC Cancer | Issue 1/2014

Abstract

Background

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cancer stem cell marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of ALDH1A1 expression with clinicopathological parameters and prognosis in gastric cancer.

Methods

ALDH1A1 and matrix metallopeptidase 9 (MMP-9) was evaluated by immunohistochemistry in 216 gastric carcinoma samples. The association between expression of ALDH1A1 and MMP-9, clinicopathological parameters, and prognosis of gastric cancer was examined.

Results

ALDH1A1 protein expression was significantly associated with depth invasion, lymph node metastasis and stage of disease (all P < 0.05). Both univariate and multivariate analyses revealed that ALDH1A1 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (both P < 0.001). Furthermore, ALDH1A1 overexpression was associated with poor prognosis in patients subgroups stratified by tumor size, depth invasion and lymph node metastasis. Moreover, ALDH1A1 was significantly correlated with MMP-9 among 216 gastric cancer tissues (P < 0.001). Patients who had ALDH1A1 overexpression, in which tumor cells displayed high invasiveness, had poor OS and shorter RFS.

Conclusion

ALDH1A1 plays an important role in tumor aggressiveness and prognosis, and may act as a promising target for prognostic prediction.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/705/prepub

Title: ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer
Authors: Xiao-shan Li
Qing Xu
Xiang-yang Fu
Wei-sheng Luo
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-14-705

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