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BMC Cancer
Published in: BMC Cancer 1/2013

Open Access 01-12-2013 | Research article

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium

Authors: Linda E Kelemen, Elisa V Bandera, Kathryn L Terry, Mary Anne Rossing, Louise A Brinton, Jennifer A Doherty, Roberta B Ness, Susanne Krüger Kjær, Jenny Chang-Claude, Martin Köbel, Galina Lurie, Pamela J Thompson, Michael E Carney, Kirsten Moysich, Robert Edwards, Clare Bunker, Allan Jensen, Estrid Høgdall, Daniel W Cramer, Allison F Vitonis, Sara H Olson, Melony King, Urmila Chandran, Jolanta Lissowska, Montserrat Garcia-Closas, Hannah Yang, Penelope M Webb, Joellen M Schildkraut, Marc T Goodman, Harvey A Risch, , on behalf of the Australian Ovarian Cancer Study Group and Australian Cancer Study (Ovarian Cancer), and on behalf of the Ovarian Cancer Association Consortium

Published in: BMC Cancer | Issue 1/2013

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Abstract

Background

Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations.

Methods

We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol.

Results

Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations.

Conclusions

We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.
Appendix
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Literature
1.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010, 127 (12): 2893-2917. 10.1002/ijc.25516.CrossRefPubMed
2.
Lynch HT, Schuelke GS, Kimberling WJ, Albano WA, Lynch JF, Biscone KA, Lipkin ML, Deschner EE, Mikol YB, Sandberg AA, et al: Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies. Cancer. 1985, 56 (4): 939-951. 10.1002/1097-0142(19850815)56:4<939::AID-CNCR2820560440>3.0.CO;2-T.CrossRefPubMed
3.
Lynch HT, Conway T, Lynch J: Hereditary ovarian cancer. Pedigree studies, Part II. Canc Genet Cytogenet. 1991, 53 (2): 161-183. 10.1016/0165-4608(91)90094-B.CrossRef
4.
Boyd J, Rubin SC: Hereditary ovarian cancer: molecular genetics and clinical implications. Gynecol Oncol. 1997, 64 (2): 196-206. 10.1006/gyno.1996.4572.CrossRefPubMed
5.
Narod SA, Madlensky L, Bradley L, Cole D, Tonin P, Rosen B, Risch HA: Hereditary and familial ovarian cancer in southern Ontario. Cancer. 1994, 74 (8): 2341-2346. 10.1002/1097-0142(19941015)74:8<2341::AID-CNCR2820740819>3.0.CO;2-Z.CrossRefPubMed
6.
Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, et al: Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet. 2001, 68 (3): 700-710. 10.1086/318787.CrossRefPubMedPubMedCentral
7.
Song H, Ramus SJ, Tyrer J, Bolton KL, Gentry-Maharaj A, Wozniak E, Anton-Culver H, Chang-Claude J, Cramer DW, DiCioccio R, et al: A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet. 2009, 41 (9): 996-1000. 10.1038/ng.424.CrossRefPubMedPubMedCentral
8.
Goode EL, Chenevix-Trench G, Song H, Ramus SJ, Notaridou M, Lawrenson K, Widschwendter M, Vierkant RA, Larson MC, Kjaer SK, et al: A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet. 2010, 42 (10): 874-879. 10.1038/ng.668.CrossRefPubMedPubMedCentral
9.
Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, Sher T, Gentry-Maharaj A, Wozniak E, Tsai YY, et al: Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2010, 42 (10): 880-884. 10.1038/ng.666.CrossRefPubMedPubMedCentral
10.
Hankinson SE, Colditz GA, Hunter DJ, Spencer TL, Rosner B, Stampfer MJ: A quantitative assessment of oral contraceptive use and risk of ovarian cancer. Obstet Gynecol. 1992, 80 (4): 708-714.PubMed
11.
The reduction in risk of ovarian cancer associated with oral-contraceptive use. The Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development. N Engl J Med. 1987, 316 (11): 650-655.
12.
Whittemore AS, Harris R, Itnyre J: Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative ovarian cancer group. Am J Epidemiol. 1992, 136 (10): 1184-1203.PubMed
13.
Risch HA, Marrett LD, Howe GR: Parity, contraception, infertility, and the risk of epithelial ovarian cancer. Am J Epidemiol. 1994, 140 (7): 585-597.PubMed
14.
Kurian AW, Balise RR, McGuire V, Whittemore AS: Histologic types of epithelial ovarian cancer: have they different risk factors?. Gynecol Oncol. 2005, 96 (2): 520-530. 10.1016/j.ygyno.2004.10.037.CrossRefPubMed
15.
Gertig DM, Hunter DJ, Cramer DW, Colditz GA, Speizer FE, Willett WC, Hankinson SE: Prospective study of talc use and ovarian cancer. J Natl Canc Inst. 2000, 92 (3): 249-252. 10.1093/jnci/92.3.249.CrossRef
16.
Huncharek M, Geschwind JF, Kupelnick B: Perineal application of cosmetic talc and risk of invasive epithelial ovarian cancer: a meta-analysis of 11,933 subjects from sixteen observational studies. Anticancer Res. 2003, 23 (2C): 1955-1960.PubMed
17.
Kelemen LE, Sellers TA, Vierkant RA, Harnack L, Cerhan JR: Association of folate and alcohol with risk of ovarian cancer in a prospective study of postmenopausal women. Canc Causes Contr. 2004, 15 (10): 1085-1093. 10.1007/s10552-004-1546-6.CrossRef
18.
Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Arslan A, Beeson WL, Buring JE, Fraser GE, Freudenheim JL, Goldbohm RA, et al: Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Canc Epidemiol Biomarkers Prev. 2006, 15 (2): 364-372. 10.1158/1055-9965.EPI-05-0484.CrossRef
19.
Kushi LH, Mink PJ, Folsom AR, Anderson KE, Zheng W, Lazovich D, Sellers TA: Prospective study of diet and ovarian cancer. Am J Epidemiol. 1999, 149 (1): 21-31. 10.1093/oxfordjournals.aje.a009723.CrossRefPubMed
20.
Fairfield KM, Hankinson SE, Rosner BA, Hunter DJ, Colditz GA, Willett WC: Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis. Cancer. 2001, 92 (9): 2318-2326. 10.1002/1097-0142(20011101)92:9<2318::AID-CNCR1578>3.0.CO;2-7.CrossRefPubMed
21.
Schulz M, Lahmann PH, Boeing H, Hoffmann K, Allen N, Key TJ, Bingham S, Wirfalt E, Berglund G, Lundin E, et al: Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition. Canc Epidemiol Biomarkers Prev. 2005, 14 (11 Pt 1): 2531-2535.CrossRef
22.
Risch HA, Marrett LD, Jain M, Howe GR: Differences in risk factors for epithelial ovarian cancer by histologic type. Results of a case-control study. Am J Epidemiol. 1996, 144 (4): 363-372. 10.1093/oxfordjournals.aje.a008937.CrossRefPubMed
23.
Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, Nagle CM, Doherty JA, Cushing-Haugen KL, Wicklund KG, et al: Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012, 13 (4): 385-394. 10.1016/S1470-2045(11)70404-1.CrossRefPubMedPubMedCentral
24.
Rossing MA, Cushing-Haugen KL, Wicklund KG, Weiss NS: Cigarette smoking and risk of epithelial ovarian cancer. Canc Causes Contr. 2008, 19 (4): 413-420. 10.1007/s10552-007-9103-8.CrossRef
25.
Green A, Purdie D, Bain C, Siskind V, Webb PM: Cigarette smoking and risk of epithelial ovarian cancer (Australia). Canc Causes Contr. 2001, 12 (8): 713-719. 10.1023/A:1011297403819.CrossRef
26.
Gwinn ML, Webster LA, Lee NC, Layde PM, Rubin GL: Alcohol consumption and ovarian cancer risk. Am J Epidemiol. 1986, 123 (5): 759-766.PubMed
27.
Webb PM, Purdie DM, Bain CJ, Green AC: Alcohol, wine, and risk of epithelial ovarian cancer.[see comment]. Canc Epidemiol Biomarkers Prev. 2004, 13 (4): 592-599.
28.
Riman T, Dickman PW, Nilsson S, Nordlinder H, Magnusson CM, Persson IR: Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women. Eur J Epidemiol. 2004, 19 (11): 1011-1019. 10.1007/s10654-004-1633-8.CrossRefPubMed
29.
Chang ET, Canchola AJ, Lee VS, Clarke CA, Purdie DM, Reynolds P, Bernstein L, Stram DO, Anton-Culver H, Deapen D, et al: Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort. Canc Causes Contr. 2007, 18 (1): 91-103. 10.1007/s10552-006-0083-x.CrossRef
30.
Peterson NB, Trentham-Dietz A, Newcomb PA, Chen Z, Hampton JM, Willett WC, Egan KM: Alcohol consumption and ovarian cancer risk in a population-based case-control study. Int J Cancer. 2006, 119 (10): 2423-2427. 10.1002/ijc.22137.CrossRefPubMed
31.
Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE: Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer. 2008, 112 (5): 1169-1177. 10.1002/cncr.23275.CrossRefPubMed
32.
La Vecchia C, Negri E, Franceschi S, Parazzini F, Gentile A, Fasoli M: Alcohol and epithelial ovarian cancer. J Clin Epidemiol. 1992, 45 (9): 1025-1030. 10.1016/0895-4356(92)90119-8.CrossRefPubMed
33.
Hartge P, Schiffman MH, Hoover R, McGowan L, Lesher L, Norris HJ: A case-control study of epithelial ovarian cancer. Am J Obstet Gynecol. 1989, 161 (1): 10-16.CrossRefPubMed
34.
Modugno F, Ness RB, Allen GO: Alcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer. Obstet Gynecol. 2003, 102 (6): 1336-1343. 10.1016/j.obstetgynecol.2003.08.008.PubMed
35.
Kuper H, Titus-Ernstoff L, Harlow BL, Cramer DW: Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. Int J Cancer. 2000, 88 (2): 313-318. 10.1002/1097-0215(20001015)88:2<313::AID-IJC26>3.0.CO;2-5.CrossRefPubMed
36.
Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Buring JE, Freudenheim JL, Goldbohm RA, Harnack L, Hankinson SE, Larsson SC, et al: Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. Br J Cancer. 2006, 94 (5): 757-762.PubMedPubMedCentral
37.
Kelemen LE, Goode EL: Alcohol intake increases risk of mucinous epithelial ovarian cancer: a meta-analysis. Am J Epidemiol. 2007, 165 (suppl): S89-Abstract #355
38.
Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, et al: Alcohol drinking and epithelial ovarian cancer risk. A systematic review and meta-analysis. Gynecol Oncol. 2012, 125 (3): 758-763. 10.1016/j.ygyno.2012.03.031.CrossRefPubMed
39.
Schouten LJ, Zeegers MP, Goldbohm RA, van den Brandt PA: Alcohol and ovarian cancer risk: results from the Netherlands Cohort Study. Canc Causes Contr. 2004, 15 (2): 201-209.CrossRef
40.
41.
Kobel M, Kalloger SE, Boyd N, McKinney S, Mehl E, Palmer C, Leung S, Bowen NJ, Ionescu DN, Rajput A, et al: Ovarian carcinoma subtypes are different diseases: implications for biomarker studies. PLoS Med. 2008, 5 (12): e232-10.1371/journal.pmed.0050232.CrossRefPubMedPubMedCentral
42.
Wong KK, Gershenson D: The continuum of serous tumors of low malignant potential and low-grade serous carcinomas of the ovary. Dis Markers. 2007, 23 (5–6): 377-387.CrossRefPubMedPubMedCentral
43.
Risch HA, Bale AE, Beck PA, Zheng W: PGR +331 A/G and increased risk of epithelial ovarian cancer. Canc Epidemiol Biomarkers Prev. 2006, 15 (9): 1738-1741. 10.1158/1055-9965.EPI-06-0272.CrossRef
44.
Rossing MA, Cushing-Haugen KL, Wicklund KG, Doherty JA, Weiss NS: Menopausal hormone therapy and risk of epithelial ovarian cancer. Canc Epidemiol Biomarkers Prev. 2007, 16 (12): 2548-2556. 10.1158/1055-9965.EPI-07-0550.CrossRef
45.
Goodman MT, Lurie G, Thompson PJ, McDuffie KE, Carney ME: Association of two common single-nucleotide polymorphisms in the CYP19A1 locus and ovarian cancer risk. Endocr Relat Canc. 2008, 15 (4): 1055-1060. 10.1677/ERC-08-0104.CrossRef
46.
Ness RB, Dodge RC, Edwards RP, Baker JA, Moysich KB: Contraception methods, beyond oral contraceptives and tubal ligation, and risk of ovarian cancer. Ann Epidemiol. 2011, 21 (3): 188-196. 10.1016/j.annepidem.2010.10.002.CrossRefPubMed
47.
Schildkraut JM, Iversen ES, Wilson MA, Clyde MA, Moorman PG, Palmieri RT, Whitaker R, Bentley RC, Marks JR, Berchuck A: Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer. PLoS One. 2010, 5 (4): e10061-10.1371/journal.pone.0010061.CrossRefPubMedPubMedCentral
48.
Schildkraut JM, Moorman PG, Bland AE, Halabi S, Calingaert B, Whitaker R, Lee PS, Elkins-Williams T, Bentley RC, Marks JR, et al: Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup. Canc Epidemiol Biomarkers Prev. 2008, 17 (3): 585-593. 10.1158/1055-9965.EPI-07-0596.CrossRef
49.
Terry KL, De Vivo I, Titus-Ernstoff L, Shih MC, Cramer DW: Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk. Cancer Res. 2005, 65 (13): 5974-5981. 10.1158/0008-5472.CAN-04-3885.CrossRefPubMedPubMedCentral
50.
Terry KL, Tworoger SS, Goode EL, Gates MA, Titus-Ernstoff L, Kelemen LE, Sellers TA, Hankinson SE, Cramer DW: MTHFR polymorphisms in relation to ovarian cancer risk. Gynecol Oncol. 2010, 119 (2): 319-324. 10.1016/j.ygyno.2010.08.007.CrossRefPubMedPubMedCentral
51.
Bandera EV, King M, Chandran U, Paddock LE, Rodriguez-Rodriguez L, Olson SH: Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study. BMC Womens Health. 2011, 11: 40-10.1186/1472-6874-11-40.CrossRefPubMedPubMedCentral
52.
Chandran U, Bandera EV, Williams-King MG, Paddock LE, Rodriguez-Rodriguez L, Lu SE, Faulkner S, Pulick K, Olson SH: Healthy eating index and ovarian cancer risk. Canc Causes Contr. 2011, 22 (4): 563-571. 10.1007/s10552-011-9728-5.CrossRef
53.
Risch HA, Jain M, Marrett LD, Howe GR: Dietary fat intake and risk of epithelial ovarian cancer. J Natl Canc Inst. 1994, 86 (18): 1409-1415. 10.1093/jnci/86.18.1409.CrossRef
54.
Royar J, Becher H, Chang-Claude J: Low-dose oral contraceptives: protective effect on ovarian cancer risk. Int J Cancer. 2001, 95 (6): 370-374. 10.1002/1097-0215(20011120)95:6<370::AID-IJC1065>3.0.CO;2-T.CrossRefPubMed
55.
Glud E, Kjaer SK, Thomsen BL, Hogdall C, Christensen L, Hogdall E, Bock JE, Blaakaer J: Hormone therapy and the impact of estrogen intake on the risk of ovarian cancer. Arch Intern Med. 2004, 164 (20): 2253-2259. 10.1001/archinte.164.20.2253.CrossRefPubMed
56.
Huusom LD, Frederiksen K, Hogdall EV, Glud E, Christensen L, Hogdall CK, Blaakaer J, Kjaer SK: Association of reproductive factors, oral contraceptive use and selected lifestyle factors with the risk of ovarian borderline tumors: a Danish case-control study. Canc Causes Contr. 2006, 17 (6): 821-829. 10.1007/s10552-006-0022-x.CrossRef
57.
Soegaard M, Jensen A, Hogdall E, Christensen L, Hogdall C, Blaakaer J, Kjaer SK: Different risk factor profiles for mucinous and nonmucinous ovarian cancer: results from the Danish MALOVA study. Canc Epidemiol Biomarkers Prev. 2007, 16 (6): 1160-1166. 10.1158/1055-9965.EPI-07-0089.CrossRef
58.
Garcia-Closas M, Brinton LA, Lissowska J, Richesson D, Sherman ME, Szeszenia-Dabrowska N, Peplonska B, Welch R, Yeager M, Zatonski W, et al: Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study. BMC Canc. 2007, 7: 60-10.1186/1471-2407-7-60.CrossRef
59.
Merritt MA, Green AC, Nagle CM, Webb PM: Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. Int J Cancer. 2008, 122 (1): 170-176. 10.1002/ijc.23017.CrossRefPubMed
60.
Ibiebele TI, Parekh S, Mallitt KA, Hughes MC, O'Rourke PK, Webb PM: Reproducibility of food and nutrient intake estimates using a semi-quantitative FFQ in Australian adults. Publ Health Nutr. 2009, 12 (12): 2359-2365. 10.1017/S1368980009005023.CrossRef
61.
Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T: Measurement characteristics of the Women's Health Initiative food frequency questionnaire. Ann Epidemiol. 1999, 9 (3): 178-187. 10.1016/S1047-2797(98)00055-6.CrossRefPubMed
62.
Hankin JH, Wilkens LR, Kolonel LN, Yoshizawa CN: Validation of a quantitative diet history method in Hawaii. Am J Epidemiol. 1991, 133 (6): 616-628.PubMed
63.
Willett W, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 1985, 122 (1): 51-65.PubMed
64.
Rothman KJ, Greenland S: Modern epidemiology. 1998, Philadelphia, PA: Lippincott-Reaven Publishers, 2
65.
Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21 (11): 1539-1558. 10.1002/sim.1186.CrossRefPubMed
66.
Smith-Warner SA, Spiegelman D, Ritz J, Albanes D, Beeson WL, Bernstein L, Berrino F, van den Brandt PA, Buring JE, Cho E, et al: Methods for pooling results of epidemiologic studies: the pooling project of prospective studies of diet and cancer. Am J Epidemiol. 2006, 163 (11): 1053-1064. 10.1093/aje/kwj127.CrossRefPubMed
67.
Willett W, Stampfer MJ: Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986, 124 (1): 17-27.PubMed
68.
Hosmer DW, Lemeshow SL: Applied logistic regression. 2000, New York, NY: John Wiley and Sons, IncCrossRef
69.
Kelemen LE, Goodman MT, McGuire V, Rossing MA, Webb PM, Kobel M, Anton-Culver H, Beesley J, Berchuck A, Brar S, et al: Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Canc Epidemiol Biomarkers Prev. 2010, 19 (7): 1822-1830. 10.1158/1055-9965.EPI-09-1317.CrossRef
70.
Seidman JD, Kurman RJ, Ronnett BM: Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol. 2003, 27 (7): 985-993. 10.1097/00000478-200307000-00014.CrossRefPubMed
71.
Kobel M, Kalloger SE, Huntsman DG, Santos JL, Swenerton KD, Seidman JD, Gilks CB: Differences in tumor type in low-stage versus high-stage ovarian carcinomas. Int J Gynecol Pathol. 2010, 29 (3): 203-211. 10.1097/PGP.0b013e3181c042b6.CrossRefPubMed
72.
Gilks CB, Ionescu DN, Kalloger SE, Kobel M, Irving J, Clarke B, Santos J, Le N, Moravan V, Swenerton K: Tumor cell type can be reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma. Hum Pathol. 2008, 39 (8): 1239-1251. 10.1016/j.humpath.2008.01.003.CrossRefPubMed
73.
Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, Taylor PR: Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA. 2002, 287 (19): 2559-2562. 10.1001/jama.287.19.2559.CrossRefPubMed
74.
Calle EE, Kaaks R: Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004, 4 (8): 579-591.CrossRefPubMed
75.
Brokaw J, Katsaros D, Wiley A, Lu L, Su D, Sochirca O, de la Longrais IA, Mayne S, Risch H, Yu H: IGF-I in epithelial ovarian cancer and its role in disease progression. Growth Factors. 2007, 25 (5): 346-354. 10.1080/08977190701838402.CrossRefPubMed
76.
Kobel M, Xu H, Bourne PA, Spaulding BO, Shih Ie M, Mao TL, Soslow RA, Ewanowich CA, Kalloger SE, Mehl E, et al: IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype. Mod Pathol. 2009, 22 (3): 469-475. 10.1038/modpathol.2008.206.CrossRefPubMed
77.
Parker AS, Cheville JC, Janney CA, Cerhan JR: High expression levels of insulin-like growth factor-I receptor predict poor survival among women with clear-cell renal cell carcinomas. Hum Pathol. 2002, 33 (8): 801-805. 10.1053/hupa.2002.126186.CrossRefPubMed
78.
Rosendahl AH, Holly JM, Celander M, Forsberg G: Systemic IGF-I administration stimulates the in vivo growth of early, but not advanced, renal cell carcinoma. Int J Cancer. 2008, 123 (6): 1286-1291. 10.1002/ijc.23642.CrossRefPubMed
79.
Kushi LH, Doyle C, McCullough M, Rock CL, Demark-Wahnefried W, Bandera EV, Gapstur S, Patel AV, Andrews K, Gansler T: American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2012, 62 (1): 30-67. 10.3322/caac.20140.CrossRefPubMed
80.
Seitz HK, Stickel F: Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007, 7 (8): 599-612.CrossRefPubMed
81.
World Cancer Research Fund/American Institute for Cancer Research: Food, nutrition, physical activity, and the prevention of cancer: a global perspective. 2007, Washington, DC: AICR
82.
Goodman MT, Tung KH: Alcohol consumption and the risk of borderline and invasive ovarian cancer. Obstet Gynecol. 2003, 101 (6): 1221-1228. 10.1016/S0029-7844(03)00050-4.PubMed
83.
Manach C, Scalbert A, Morand C, Remesy C, Jimenez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004, 79 (5): 727-747.PubMed
84.
Scalbert A, Manach C, Morand C, Remesy C, Jimenez L: Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005, 45 (4): 287-306. 10.1080/1040869059096.CrossRefPubMed
85.
Lee JE, Hunter DJ, Spiegelman D, Adami HO, Albanes D, Bernstein L, van den Brandt PA, Buring JE, Cho E, Folsom AR, et al: Alcohol intake and renal cell cancer in a pooled analysis of 12 prospective studies. J Natl Canc Inst. 2007, 99 (10): 801-810. 10.1093/jnci/djk181.CrossRef
86.
Gavallos G, Tawfik O, Herrell D, Langenstroer P: Renal-ovarian axis: a case report and review. Urology. 2003, 62 (4): 749-CrossRefPubMed
87.
Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, et al: Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling. Canc Sci. 2010, 101 (12): 2658-2663. 10.1111/j.1349-7006.2010.01736.x.CrossRef
88.
Zorn KK, Bonome T, Gangi L, Chandramouli GV, Awtrey CS, Gardner GJ, Barrett JC, Boyd J, Birrer MJ: Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Clin Cancer Res. 2005, 11 (18): 6422-6430. 10.1158/1078-0432.CCR-05-0508.CrossRefPubMed
89.
Risch HA: Hormone replacement therapy and the risk of ovarian cancer. Gynecol Oncol. 2002, 86 (2): 115-117. 10.1006/gyno.2002.6774.CrossRefPubMed
Metadata
Title
Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
Authors
Linda E Kelemen
Elisa V Bandera
Kathryn L Terry
Mary Anne Rossing
Louise A Brinton
Jennifer A Doherty
Roberta B Ness
Susanne Krüger Kjær
Jenny Chang-Claude
Martin Köbel
Galina Lurie
Pamela J Thompson
Michael E Carney
Kirsten Moysich
Robert Edwards
Clare Bunker
Allan Jensen
Estrid Høgdall
Daniel W Cramer
Allison F Vitonis
Sara H Olson
Melony King
Urmila Chandran
Jolanta Lissowska
Montserrat Garcia-Closas
Hannah Yang
Penelope M Webb
Joellen M Schildkraut
Marc T Goodman
Harvey A Risch
, on behalf of the Australian Ovarian Cancer Study Group and Australian Cancer Study (Ovarian Cancer)
and on behalf of the Ovarian Cancer Association Consortium
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2013
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-13-28

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