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BMC Cancer
Published in: BMC Cancer 1/2012

Open Access 01-12-2012 | Research article

AB0 blood group and prognosis in patients with pancreatic cancer

Authors: Nuh N Rahbari, Ulrich Bork, Ulf Hinz, Albrecht Leo, Johanna Kirchberg, Moritz Koch, Markus W Büchler, Jürgen Weitz

Published in: BMC Cancer | Issue 1/2012

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Abstract

Background

Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer.

Methods

A total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses.

Results

In patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 – 0.99; p = 0.037).

Conclusion

AB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.
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Metadata
Title
AB0 blood group and prognosis in patients with pancreatic cancer
Authors
Nuh N Rahbari
Ulrich Bork
Ulf Hinz
Albrecht Leo
Johanna Kirchberg
Moritz Koch
Markus W Büchler
Jürgen Weitz
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2012
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-12-319

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