Skip to main content
Top
Published in: BMC Nephrology 1/2014

Open Access 01-12-2014 | Correspondence

Importance of Arsenic and pesticides in epidemic chronic kidney disease in Sri Lanka

Authors: Channa Jayasumana, Ranil Gajanayake, Sisira Siribaddana

Published in: BMC Nephrology | Issue 1/2014

Login to get access

Abstract

In a recent study published by the National Project team on chronic kidney diseases of unknown origin in Sri Lanka, we believe there to be flaws in the design, analysis, and conclusions, which should be discussed further. The authors wanted to emphasis Cadmium as the major risk factor for chronic kidney disease of unknown etiology in Sri Lanka while undermining the importance of Arsenic and nephrotoxic pesticides. To arrive at predetermined conclusions the authors appear have changed and misinterpreted their own results. The enormous pressure applied by the agrochemical industry on this issue may be a factor. Herein, we discuss these issues in greater detail.
Appendix
Available only for authorised users
Literature
1.
go back to reference Jayatilake N, Mendis S, Maheepala P, Mehta FR: Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country. BMC Nephrol. 2013, 14: 180-10.1186/1471-2369-14-180.CrossRefPubMedPubMedCentral Jayatilake N, Mendis S, Maheepala P, Mehta FR: Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country. BMC Nephrol. 2013, 14: 180-10.1186/1471-2369-14-180.CrossRefPubMedPubMedCentral
3.
go back to reference Chandrajith R, Nanayakkara S, Itai K, Aturaliya TNC, Dissanayake CB, Abeysekera T, Harada K, Watanabe T, Koizumi A: Chronic kidney diseases of uncertain etiology (CKDue) in Sri Lanka: geographic distribution and environmental implications. Environ Geochem Health. 2011, 33: 267-278. 10.1007/s10653-010-9339-1.CrossRefPubMed Chandrajith R, Nanayakkara S, Itai K, Aturaliya TNC, Dissanayake CB, Abeysekera T, Harada K, Watanabe T, Koizumi A: Chronic kidney diseases of uncertain etiology (CKDue) in Sri Lanka: geographic distribution and environmental implications. Environ Geochem Health. 2011, 33: 267-278. 10.1007/s10653-010-9339-1.CrossRefPubMed
4.
go back to reference Jayasumana C, Gunatilake S, Senanayake P: Glyphosate, hard water and nephrotoxic metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka?. Int J Environ Res Public Health. 2014, 11: 2125-2147. 10.3390/ijerph110202125.CrossRefPubMedPubMedCentral Jayasumana C, Gunatilake S, Senanayake P: Glyphosate, hard water and nephrotoxic metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka?. Int J Environ Res Public Health. 2014, 11: 2125-2147. 10.3390/ijerph110202125.CrossRefPubMedPubMedCentral
6.
go back to reference Wanigasuriya KP, Peiris-John RJ, Wickremasinghe R: Chronic kidney disease of unknown aetiology in Sri Lanka: is Cd a likely cause?. BMC Nephrol. 2011, 12: 32-10.1186/1471-2369-12-32.CrossRefPubMedPubMedCentral Wanigasuriya KP, Peiris-John RJ, Wickremasinghe R: Chronic kidney disease of unknown aetiology in Sri Lanka: is Cd a likely cause?. BMC Nephrol. 2011, 12: 32-10.1186/1471-2369-12-32.CrossRefPubMedPubMedCentral
7.
go back to reference Herath HMNJ, Wazil AWM, Abeysekara DTDJ, Jeewani NDC, Weerakoon KGAD, Ratnatunga NVI, Bandara EHCK, Kularatne SAM: Chronic kidney disease in snake envenomed patients with acute kidney injury in Sri Lanka: a descriptive study. Postgrad Med J. 2012, 88 (1037): 138-142. 10.1136/postgradmedj-2011-130225.CrossRefPubMed Herath HMNJ, Wazil AWM, Abeysekara DTDJ, Jeewani NDC, Weerakoon KGAD, Ratnatunga NVI, Bandara EHCK, Kularatne SAM: Chronic kidney disease in snake envenomed patients with acute kidney injury in Sri Lanka: a descriptive study. Postgrad Med J. 2012, 88 (1037): 138-142. 10.1136/postgradmedj-2011-130225.CrossRefPubMed
9.
go back to reference George CM, Gamble M, Slavkovich V, Levy D, Ahamed A, Ashan H, Graziano J: A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. Environ Heal. 2013, 12: 52-10.1186/1476-069X-12-52.CrossRef George CM, Gamble M, Slavkovich V, Levy D, Ahamed A, Ashan H, Graziano J: A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh. Environ Heal. 2013, 12: 52-10.1186/1476-069X-12-52.CrossRef
11.
go back to reference Haddam N, Samira S, Dumont X, Taleb A, Lison D, Haufroid V, Bernard A: Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers. Environ Health. 2011, 10: 37-10.1186/1476-069X-10-37.CrossRefPubMedPubMedCentral Haddam N, Samira S, Dumont X, Taleb A, Lison D, Haufroid V, Bernard A: Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers. Environ Health. 2011, 10: 37-10.1186/1476-069X-10-37.CrossRefPubMedPubMedCentral
12.
go back to reference Nanayakkara S, Senevirathna S, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne E, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A: An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014, 56 (1): 28-38. 10.1539/joh.13-0172-OA.CrossRefPubMed Nanayakkara S, Senevirathna S, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne E, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A: An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014, 56 (1): 28-38. 10.1539/joh.13-0172-OA.CrossRefPubMed
13.
go back to reference Akerstrom M, Sallsten G, Lundh T, Barregard L: Association between urinary excretion of Cadmium and protein in a non smokoing population: renal toxicity or normal physiology. Environ Health Perspect. 2013, 121 (2): 787-792. Akerstrom M, Sallsten G, Lundh T, Barregard L: Association between urinary excretion of Cadmium and protein in a non smokoing population: renal toxicity or normal physiology. Environ Health Perspect. 2013, 121 (2): 787-792.
14.
go back to reference Chandrajith R, Seneviratna S, Wickramaarachchi K, Attanayake T, Aturaliya TNC, Dissanayake CB: Natural radionuclides and trace elements in rice field soils in relation to fertilizer application: study of a chronic kidney disease area in Sri Lanka. Environ Earth Sci. 2009, 60: 193-201.CrossRef Chandrajith R, Seneviratna S, Wickramaarachchi K, Attanayake T, Aturaliya TNC, Dissanayake CB: Natural radionuclides and trace elements in rice field soils in relation to fertilizer application: study of a chronic kidney disease area in Sri Lanka. Environ Earth Sci. 2009, 60: 193-201.CrossRef
15.
go back to reference Jayasumana MACS, Paranagama PA, Amarasinghe MD, Fonseka SI, Wijekoon DVK: Presence of Arsenic in pesticides used in Sri Lanka. Proceedings of the Water Prof Day Symp: 1st Oct 2011; Peradeniya. Edited by: Dayawansa NDK, De Silva RP. 2011, Sri Lanka: Post graduate Institute of Agriculture, 127-141. Jayasumana MACS, Paranagama PA, Amarasinghe MD, Fonseka SI, Wijekoon DVK: Presence of Arsenic in pesticides used in Sri Lanka. Proceedings of the Water Prof Day Symp: 1st Oct 2011; Peradeniya. Edited by: Dayawansa NDK, De Silva RP. 2011, Sri Lanka: Post graduate Institute of Agriculture, 127-141.
16.
go back to reference Wickramaarachchi WDN: PhD thesis. University of Peradeniya, Sri Lanka. Irrigation water quality along the cascade system in the north east Dry zone of Sri Lanka. 2005 Wickramaarachchi WDN: PhD thesis. University of Peradeniya, Sri Lanka. Irrigation water quality along the cascade system in the north east Dry zone of Sri Lanka. 2005
17.
go back to reference Jayasumana MACS, Gajanayake R, Siribaddana SH: Importance of Arsenic and pesticides in epidemic chronic kidney disease in Sri Lanka. BMC Nephrol. 2014 Jayasumana MACS, Gajanayake R, Siribaddana SH: Importance of Arsenic and pesticides in epidemic chronic kidney disease in Sri Lanka. BMC Nephrol. 2014
18.
go back to reference Final Mission Report: Research on Kidney Disease of Uncertain Aetiology (CKDu) in Sri Lanka; National CKDu Project. 2013, Geneva: World Health Organization Final Mission Report: Research on Kidney Disease of Uncertain Aetiology (CKDu) in Sri Lanka; National CKDu Project. 2013, Geneva: World Health Organization
Metadata
Title
Importance of Arsenic and pesticides in epidemic chronic kidney disease in Sri Lanka
Authors
Channa Jayasumana
Ranil Gajanayake
Sisira Siribaddana
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2014
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/1471-2369-15-124

Other articles of this Issue 1/2014

BMC Nephrology 1/2014 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.