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Open Access 01-12-2010 | Research article

Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

Authors: Takeshi Hattori, Satoshi Konno, Ayumu Takahashi, Akira Isada, Kaoruko Shimizu, Kenichi Shimizu, Natsuko Taniguchi, Peisong Gao, Etsuro Yamaguchi, Nobuyuki Hizawa, Shau-Ku Huang, Masaharu Nishimura

Published in: BMC Medical Genetics | Issue 1/2010

Abstract

Background

Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis.

Methods

Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls.

Results

Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001).

Conclusions

These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/11/151/prepub

Title: Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
Authors: Takeshi Hattori
Satoshi Konno
Ayumu Takahashi
Akira Isada
Kaoruko Shimizu
Kenichi Shimizu
Natsuko Taniguchi
Peisong Gao
Etsuro Yamaguchi
Nobuyuki Hizawa
Shau-Ku Huang
Masaharu Nishimura
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2010
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-11-151

At a glance: The STEP trials

Springer Medicine

Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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