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BMC Medical Genetics

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Open Access 01-12-2010 | Research article

EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study

Authors: Cindy L Ehlers, Ian R Gizer, Evelyn Phillips, Kirk C Wilhelmsen

Published in: BMC Medical Genetics | Issue 1/2010

Abstract

Background

Evidence for a high degree of heritability of EEG alpha phenotypes has been demonstrated in twin and family studies in a number of populations. However, information on linkage of this phenotype to specific chromosome locations is still limited. This study's aims were to map loci linked to EEG alpha phenotypes and to determine if there was overlap with loci previously mapped for alcohol dependence in an American Indian community at high risk for substance dependence.

Methods

Each participant gave a blood sample and completed a structured diagnostic interview using the Semi Structured Assessment for the Genetics of Alcoholism. Bipolar EEGs were collected and spectral power determined in the alpha (7.5-12.0 Hz) frequency band for two composite scalp locations previously identified by principal components analyses (bilateral fronto-central and bilateral centro-parietal-occipital). Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 410 members of multiplex families using SOLAR.

Results

Sixty percent of this study population had a lifetime diagnosis of alcohol dependence. Analyses of multipoint variance component LOD scores, for the EEG alpha power phenotype, revealed two loci that had a LOD score of 3.0 or above for the fronto-central scalp region on chromosomes 1 and 6. Additionally, 4 locations were identified with LOD scores above 2.0 on chromosomes 4, 11, 14, 16 for the fronto-central location and one on chromosome 2 for the centro-parietal-occipital location.

Conclusion

These results corroborate the importance of regions on chromosome 4 and 6 highlighted in prior segregation studies in this and other populations for alcohol dependence-related phenotypes, as well as other areas that overlap with other substance dependence phenotypes identified in previous linkage studies in other populations. These studies additionally support the construct that EEG alpha recorded from fronto-central scalp areas may represent an important endophenotype associated with alcohol and other substance dependence.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/11/43/prepub

Title: EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study
Authors: Cindy L Ehlers
Ian R Gizer
Evelyn Phillips
Kirk C Wilhelmsen
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2010
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-11-43

Keynote webinar | Spotlight on medication adherence

Springer Medicine

EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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