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BMC Infectious Diseases
Published in: BMC Infectious Diseases 4/2014

Open Access 01-05-2014 | Poster presentation

The prevalence of RT 245 codon polymorphisms and its association with duration of infection among HIV-1 patients in Serbia

Authors: Valentina Nikolic, Dubravka Salemovic, Djordje Jevtovic, Ivana Pesic-Pavlovic, Sonja Zerjav, Marina Siljic, Jovan Ranin, Maja Stanojevic

Published in: BMC Infectious Diseases | Special Issue 4/2014

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Excerpt

Amino acid (aa) substitutions at position 245 of HIV-1 reverse transcriptase (RT) have been described to be associated to the presence of human leukocyte antigen (HLA)–B*5701 allele in the host, in particular in subtype B infection. Preliminary data show HLA–B*5701 prevalence of around 6.5% in Serbian population. In this study, we investigated the prevalence of RT codon 245 substitutions among HIV infected patients in Serbia. Furthermore, we analyzed the association between RT 245 aa substitutions with duration of infection, estimated by proportion of ambiguous basecalls per sequence. …
Metadata
Title
The prevalence of RT 245 codon polymorphisms and its association with duration of infection among HIV-1 patients in Serbia
Authors
Valentina Nikolic
Dubravka Salemovic
Djordje Jevtovic
Ivana Pesic-Pavlovic
Sonja Zerjav
Marina Siljic
Jovan Ranin
Maja Stanojevic
Publication date
01-05-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue Special Issue 4/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S4-P4

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