Published in:
Open Access
01-05-2014 | Poster presentation
Exploring the protein-protein interface of integrin-galectin complex for drug development against HIV infection- a bioinformatics study
Authors:
M Xavier Suresh, R Barani Kumar, V Sravani, P Suma Priya
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
The formation of protein-protein complexes of the transmembrane receptor integrin and galactoside binding protein galectin assist in adhesion by bridging between cells or cells and the extracellular matrix and form adhesive networks. When HIV is present the galectin bridges between the CD4 co receptor and gp120 ligands thus facilitating HIV infection of the T cell. The main aim of this study is to investigate the interaction of galectin-3 with glycoligands, integrin, natural compound curcumin and its analogs. …