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Published in: BMC Infectious Diseases 3/2014

Open Access 01-05-2014 | Poster presentation

Exploring the protein-protein interface of integrin-galectin complex for drug development against HIV infection- a bioinformatics study

Authors: M Xavier Suresh, R Barani Kumar, V Sravani, P Suma Priya

Published in: BMC Infectious Diseases | Special Issue 3/2014

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Excerpt

The formation of protein-protein complexes of the transmembrane receptor integrin and galactoside binding protein galectin assist in adhesion by bridging between cells or cells and the extracellular matrix and form adhesive networks. When HIV is present the galectin bridges between the CD4 co receptor and gp120 ligands thus facilitating HIV infection of the T cell. The main aim of this study is to investigate the interaction of galectin-3 with glycoligands, integrin, natural compound curcumin and its analogs. …
Metadata
Title
Exploring the protein-protein interface of integrin-galectin complex for drug development against HIV infection- a bioinformatics study
Authors
M Xavier Suresh
R Barani Kumar
V Sravani
P Suma Priya
Publication date
01-05-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue Special Issue 3/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S3-P78

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