Published in:
Open Access
01-05-2014 | Poster presentation
Homozygous KIR2DL3 confers susceptibility to tuberculosis infection in HIV seropositive individuals
Authors:
Stalinraja Maruthamuthu, Suresh Madasamy, Jayalakshmi Mariakuttikan
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
Tuberculosis (TB) remains an important cause of death among patients infected with HIV. Genetic variation influences differential development of TB particularly in Immunosupressed patients. Natural Killer cells play an important role in the innate immune system by providing the first line of defence against viral infections and tumors. Their activity is partially controlled by distinct inhibitory and activating killer Ig like receptors (KIR) that recognize specific ligands on potential target cells. Objective of this study is to determine the association between KIR and HIV co-infection. …