Published in:
Open Access
01-05-2014 | Poster presentation
Hepatitis C virus infection contributes to impregnation of markers of immune inhibition: potential preludes underlying viral latency and persistence
Authors:
Muttiah Barathan, Mohamed Rosmawati, Jamuna Vadivelu, Marie Larsson, Vijayakumar Velu, Saeidi Alireza, Li Yen Chang, Esaki Muthu Shankar
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
Hepatitis C virus (HCV) represents one of the persistent viral infections afflicting humankind, and a significant proportion of chronic HCV disease progresses over time through liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). One potential mechanism underlying the chronic disease is believed to be viral escape from immune surveillance via upregulation of inhibitory molecules on immune cells by HCV. We investigated the diverse expression of various inhibitory molecules in PBMCs of healthy non-HCV controls and chronically HCV infected patients. …