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Published in: BMC Infectious Diseases 3/2014

Open Access 01-05-2014 | Oral presentation

Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies

Authors: Erica L Johnson, Hin Chu, Siddappa N Byrareddy, Paul Spearman, Rana Chakraborty

Published in: BMC Infectious Diseases | Special Issue 3/2014

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Excerpt

Within monocyte derived macrophages, HIV-1 accumulates in virus containing compartments (VCCs) that are largely inaccessible to the external environment, which implicate these cells as HIV-1 reservoirs. During mother to child transmission, placental macrophages (Hofbauer Cells [HCs]) are viral targets, and have shown to be infected in vivo and sustain low levels of viral replication in vitro, however, the risk of in utero transmission is less than 7%. The role of these primary macrophages as viral reservoirs is largely undefined. …
Metadata
Title
Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies
Authors
Erica L Johnson
Hin Chu
Siddappa N Byrareddy
Paul Spearman
Rana Chakraborty
Publication date
01-05-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue Special Issue 3/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S3-O5

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