Published in:
Open Access
01-05-2014 | Oral presentation
Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin and DC SIGN positive compartments that are accessible to neutralizing antibodies
Authors:
Erica L Johnson, Hin Chu, Siddappa N Byrareddy, Paul Spearman, Rana Chakraborty
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
Within monocyte derived macrophages, HIV-1 accumulates in virus containing compartments (VCCs) that are largely inaccessible to the external environment, which implicate these cells as HIV-1 reservoirs. During mother to child transmission, placental macrophages (Hofbauer Cells [HCs]) are viral targets, and have shown to be infected in vivo and sustain low levels of viral replication in vitro, however, the risk of in utero transmission is less than 7%. The role of these primary macrophages as viral reservoirs is largely undefined. …