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Open Access 01-05-2014 | ePoster presentation

Tenofovir induced renal damage is associated with activation of NF-κB inflammatory signaling pathway and PARP overactivation

Authors: Hemalatha Ramamoorthy, Bina Isaac, Premila Abraham

Published in: BMC Infectious Diseases | Special Issue 3/2014

Excerpt

Tenofovir is recommended as a first-line therapy in HIV treatment. However, its long term use is associated with proximal tubular injury and renal dysfunction. Tenofovir has been shown to target the proximal tubular mitochondria, resulting in severe mitochondrial injury and overproduction of ROS and RNS. ROS are potent stimuli for the activation of NF-κB, a key transcription factor, which is known to mediate inflammation.The NF-κB response proinflammatory genes include iNOS, COX, TNFα, and others such as PARP-1. In the present study, we investigated whether NF-κB inflammatory signaling pathway plays a role in tenofovir nephrotoxicity. …

Title: Tenofovir induced renal damage is associated with activation of NF-κB inflammatory signaling pathway and PARP overactivation
Authors: Hemalatha Ramamoorthy
Bina Isaac
Premila Abraham
Publication date: 01-05-2014
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue Special Issue 3/2014
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/1471-2334-14-S3-E5

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