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BMC Infectious Diseases
Published in: BMC Infectious Diseases 3/2014

Open Access 01-05-2014 | ePoster presentation

The PknI and DacB2 double deletion mutant of Mycobacterium tuberculosis leads to alteration of cell morphology and susceptibility to antibiotics

Authors: Srinivasan Kandasamy, Sujatha Narayanan

Published in: BMC Infectious Diseases | Special Issue 3/2014

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Excerpt

Mycobacterium tuberculosis is a slow growing infectious pathogen. It takes twenty hours for a single cell to divide into two. Its cell division is complex involving a number of proteins. Although, the physiological roles of several serine/threonine phosphorylation connected to cell division and peptidoglycan synthesis have been studied the exact mechanism is not clear. PknI and DacB2 located in a same cluster have been shown to play a role in cell division and cell wall synthesis. The aim of this present study was to construct the double deletion mutant (DKO) of PknI and DacB2 and study the effect on cell morphology and antibiotic susceptibility. …
Metadata
Title
The PknI and DacB2 double deletion mutant of Mycobacterium tuberculosis leads to alteration of cell morphology and susceptibility to antibiotics
Authors
Srinivasan Kandasamy
Sujatha Narayanan
Publication date
01-05-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue Special Issue 3/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S3-E22

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