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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2012

Open Access 01-12-2012 | Research article

Burden of community-acquired and nosocomial rotavirus gastroenteritis in the pediatric population of Western Europe: a scoping review

Authors: Isla Ogilvie, Hanane Khoury, Mireille M Goetghebeur, Antoine C El Khoury, Carlo Giaquinto

Published in: BMC Infectious Diseases | Issue 1/2012

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Abstract

Background

Rotavirus affects 95% of children worldwide by age 5 years and is the leading cause of severe dehydrating diarrhea. The objective of this review was to estimate the burden of rotavirus gastroenteritis (RVGE) in the Western European pediatric population.

Methods

A comprehensive literature search (1999-2010) was conducted in PubMed and other sources (CDC; WHO, others). Data on the epidemiology and burden of RVGE among children < 5 years-old in Western Europe --including hospital-acquired disease--were extracted.

Results

76 studies from 16 countries were identified. The mean percentage of acute gastroenteritis (AGE) cases caused by rotavirus ranged from 25.3%-63.5% in children < 5 years of age, peaking during winter. Incidence rates of RVGE ranged from 1.33-4.96 cases/100 person- years. Hospitalization rates for RVGE ranged from 7% to 81% among infected children, depending on the country. Nosocomial RVGE accounted for 47%-69% of all hospital-acquired AGE and prolonged hospital stays by 4-12 days. Each year, RVGE incurred $0.54- $53.6 million in direct medical costs and $1.7-$22.4 million in indirect costs in the 16 countries studied. Full serotyping data was available for 8 countries. G1P[8], G2P[4], G9P[8], and G3P[8] were the most prevalent serotypes (cumulative frequency: 57.2%- 98.7%). Serotype distribution in nosocomial RVGE was similar.

Conclusions

This review confirms that RVGE is a common disease associated with significant morbidity and costs across Western Europe. A vaccine protecting against multiple serotypes may decrease the epidemiological and cost burden of RVGE in Western Europe.
Appendix
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Literature
1.
2.
Widdowson M-A, Steele D, Vojdani J, Wecker J, Parashar UD: Global rotavirus surveillance: preparing for the introduction of rotavirus vaccines. J Infect Dis. 2009, 200: S1-S8. 10.1086/605061.PubMed
3.
Soriano-Gabarro M, Mrukowicz J, Vesikari T, Verstraeten T: Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J. 2006, 25: S7-S11. 10.1097/01.inf.0000197622.98559.01.PubMed
4.
Gleizes O, Desselberger U, Tatochenko V, Rodrigo C, Salman N, Mezner Z, Giaquinto C, Grimprel E: Nosocomial rotavirus infection in European countries: a review of the epidemiology, severity and economic burden of hospital-acquired rotavirus disease. Pediatr Infect Dis J. 2006, 25: S12-S21. 10.1097/01.inf.0000197563.03895.91.PubMed
5.
Diggle L: Rotavirus diarrhoea and future prospects for prevention. Br J Nurs. 2007, 16: 970-974.PubMed
6.
Iturriza-Gomara M, Green J, Brown DW, Ramsay M, Desselberger U, Gray JJ: Molecular epidemiology of human group A rotavirus infections in the United Kingdom between 1995 and 1998. J Clin Microbiol. 2000, 38: 4394-4401.PubMedPubMedCentral
7.
Iturriza-Gomara M, Kang G, Gray J: Rotavirus genotyping: keeping up with an evolving population of human rotaviruses. J Clin Virol. 2004, 31: 259-265. 10.1016/j.jcv.2004.04.009.PubMed
8.
Matthijnssens J, Rahman M, Ciarlet M, Van Ranst M: Emerging Human Rotavirus Genotypes. Viruses in the Environment. Edited by: Palumbo E, Kirkwood C. 2009, Kerala, India: Research Signpost, 171-219.
9.
Grimwood K, Lambert SB: Rotavirus vaccines: opportunities and challenges. Hum Vaccin. 2009, 5: 57-69. 10.4161/hv.5.2.6924.PubMed
10.
11.
Ruuska T, Vesikari T: Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis. 1990, 22: 259-267. 10.3109/00365549009027046.PubMed
12.
Cilla G, Gomariz M, Montes M, Mendiburu MI, Perez-Yarza EG, Perez-Trallero E: Incidence of hospitalization due to community-acquired rotavirus infection: a 12-year study (1996-2008). Epidemiol Infect. 2010, 1-7.
13.
14.
15.
Fruhwirth M, Heininger U, Ehlken B, Petersen G, Laubereau B, Moll-Schuler I, Mutz I, Forster J: International variation in disease burden of rotavirus gastroenteritis in children with community- and nosocomially acquired infection. Pediatr Infect Dis J. 2001, 20: 784-791. 10.1097/00006454-200108000-00013.PubMed
16.
Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der WM: Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004-2005: the REVEAL study. J Infect Dis. 2007, 195 (Suppl 1): S4-S16.PubMed
17.
Huet F, Chouchane M, Cremillieux C, Aubert M, Caulin E, Pothier P, Allaert FA: Prospective epidemiological study of rotavirus gastroenteritis in Europe (REVEAL study). Results in the French area of the study. Arch Pediatr. 2008, 15: 362-374. 10.1016/j.arcped.2008.01.021.PubMed
18.
Karsten C, Baumgarte S, Friedrich AW, von Eiff C, Becker K, Wosniok W, Ammon A, Bockemuhl J, Karch H, Huppertz HI: Incidence and risk factors for community-acquired acute gastroenteritis in north-west Germany in 2004. Eur J Clin Microbiol Infect Dis. 2009, 28: 935-943. 10.1007/s10096-009-0729-1.PubMedPubMedCentral
19.
Giaquinto C, Callegaro S, Andreola B, Bernuzzi M, Cantarutti L, D'Elia R, Drago S, De Marchi A, Falconi P, Felice M, et al: Prospective study of the burden of acute gastroenteritis and rotavirus gastroenteritis in children less than 5 years of age, in Padova, Italy. Infection. 2008, 36: 351-357. 10.1007/s15010-008-7200-6.PubMed
20.
Fau C, Billaud G, Pinchinat S, Lina B, Kaplon J, Pothier P, Derrough T, Marcelon L, Largeron N, Caulin E, et al: Epidemiology and burden of rotavirus diarrhea in day care centers in Lyon, France. Arch Pediatr. 2008, 15: 1183-1192. 10.1016/j.arcped.2008.02.016.PubMed
21.
Floret D, Lina B, Pinchinat S, Billaud G, Ait-Belghiti F, Largeron N, Bellemin B, Trang CN, Fau C, Gaspard C, et al: Epidemiology and burden of rotavirus diarrhea in day care centers in Lyon, France. Eur J Pediatr. 2006, 165: 905-906. 10.1007/s00431-006-0187-z.PubMed
22.
Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI: Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003, 9: 565-572. 10.3201/eid0905.020562.PubMedPubMedCentral
23.
Vesikari T, Rautanen T, Von Bonsdorff CH: Rotavirus gastroenteritis in Finland: burden of disease and epidemiological features. Acta Paediatr Suppl. 1999, 88: 24-30.PubMed
24.
Melliez H, Levybruhl D, Boelle PY, Dervaux B, Baron S, Yazdanpanah Y: Cost and cost-effectiveness of childhood vaccination against rotavirus in France. Vaccine. 2008, 26: 706-715. 10.1016/j.vaccine.2007.11.064.PubMed
25.
Forster J, Guarino A, Parez N, Moraga F, Roman E, Mory O, Tozzi AE, de Aguileta AL, Wahn U, Graham C, et al: Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age. Pediatrics. 2009, 123: e393-e400. 10.1542/peds.2008-2088.PubMed
26.
Thuret A, Patural H, Berthelot P, Benzait F, Martin I, Jusot JF, Teyssier G, Fabry J, Pozzetto B: Prospective follow-up of hospital-acquired diarrhoea in 28 paediatric wards of the south-east part of France during a winter season. Pathol Biol (Paris). 2004, 52: 131-137. 10.1016/j.patbio.2003.06.005.
27.
Piednoir E, Bessaci K, Bureau-Chalot F, Sabouraud P, Brodard V, Andreoletti L, Bajolet O: Economic impact of healthcare-associated rotavirus infection in a paediatric hospital. J Hosp Infect. 2003, 55: 190-195. 10.1016/j.jhin.2003.07.002.PubMed
28.
Marc E, Biscardi S, Soulier M, Lebon P, Gendrel D: Nosocomial rotavirus infections in a pediatric unit: surveillance during four successive winters. Med Mal Infect. 2007, 37: 61-66. 10.1016/j.medmal.2006.09.007.PubMed
29.
Gil-Prieto R, San Martin M, Lopez dA, Alvaro-Meca A, Gonzalez A, Gil dM: Hospital-acquired rotavirus infections in Spain over a ten-year period (1998-2007). Hum Vaccin. 2009, 5:
30.
Gutierrez-Gimeno MV, Martin-Moreno JM, Diez-Domingo J, Asensi-Botet F, Hernandez-Marco R, Correcher-Medina P, Sanchez-Fauquier A: Nosocomial Rotavirus Gastroenteritis in Spain: A Multicentre Prospective Study. Pediatr Infect Dis J. 2009
31.
Fruhwirth M, Karmaus W, Moll-Schuler I, Brosl S, Mutz I: A prospective evaluation of community acquired gastroenteritis in paediatric practices: impact and disease burden of rotavirus infection. Arch Dis Child. 2001, 84: 393-397. 10.1136/adc.84.5.393.PubMedPubMedCentral
32.
Biermann KP, Neri S, Reali MF, De Martino M, Festini F: Incidence of nosocomial rotavirus infections in a pediatric hospital over a 3-year period. Minerva Pediatr. 2006, 58: 477-482.PubMed
33.
Herruzo R, Omenaca F, Garcia S, Diez J, Sanchez-Fauquier A: Identification of risk factors associated with nosocomial infection by rotavirus P4G2, in a neonatal unit of a tertiary-care hospital. Clin Microbiol Infect. 2009, 15: 280-285. 10.1111/j.1469-0691.2008.02667.x.PubMed
34.
Giaquinto C, Van Damme P, Huet F, Gothefors L, Maxwell M, Todd P, da Dalt L: Clinical consequences of rotavirus acute gastroenteritis in Europe, 2004-2005: the REVEAL study. J Infect Dis. 2007, 195 (Suppl 1): S26-S35.PubMed
35.
Giaquinto C, Van Damme P: Age distribution of paediatric rotavirus gastroenteritis cases in Europe: the REVEAL study. Scand J Infect Dis. 2010, 42: 142-147. 10.3109/00365540903380495.PubMed
36.
Iturriza-Gomara M, Dallman T, Banyai K, Bottiger B, Buesa J, Diedrich S, Fiore L, Johansen K, Korsun N, Kroneman A, et al: Rotavirus surveillance in europe, 2005-2008: web-enabled reporting and real-time analysis of genotyping and epidemiological data. J Infect Dis. 2009, 200 (Suppl 1): S215-S221.PubMed
37.
Rouget F, Chomienne F, Laurens E, Radet C, Seguin G: Evaluation of a prevention program against nosocomial rotavirus infections in a pediatric ward. Arch Pediatr. 2000, 7: 948-954. 10.1016/S0929-693X(00)90008-3.PubMed
38.
Pina P, Le Huidoux P, Lefflot S, Araujo E, Bellaiche M, Harzig M, Allouch PY, Foucaud P: Nosocomial rotavirus infections in a general pediatric ward: epidemiology, molecular typing and risk factors. Arch Pediatr. 2000, 7: 1050-1058. 10.1016/S0929-693X(00)00312-2.PubMed
39.
Maille L, Beby-Defaux A, Bourgoin A, Koulmann L, Eucher V, Cardona J, Oriot D, Agius G: Nosocomial infections due to rotavirus and respiratory syncytial virus in pediatric wards: a 2-year study. Ann Biol Clin (Paris). 2000, 58: 601-606.
40.
Armengaud JB, El Hajje MJ, Moulin F, Marc E, Chalumeau M, Lebon P, Gendrel D: Simultaneous outbreaks of rotavirus and respiratory syncytial virus in Paris: a 12-year survey. Med Mal Infect. 2007, 37: 262-265. 10.1016/j.medmal.2007.02.005.PubMed
41.
Doit C, Mariani-Kurkdjian P, Bourrillon A, Bingen E: Rotavirus infections in a paediatric hospital during 5 years. Arch Pediatr. 2007, 14: 1465-1467. 10.1016/j.arcped.2007.10.002.PubMed
42.
Berner R, Schumacher RF, Hameister S, Forster J: Occurrence and impact of community-acquired and nosocomial rotavirus infections-a hospital-based study over 10 y. Acta Paediatr Suppl. 1999, 88: 48-52.PubMed
43.
Johansen K, Hedlund KO, Zweygberg-Wirgart B, Bennet R: Complications attributable to rotavirus-induced diarrhoea in a Swedish paediatric population: report from an 11-year surveillance. Scand J Infect Dis. 2008, 40: 958-964. 10.1080/00365540802415509.PubMed
44.
Lynch M, O'Halloran F, Whyte D, Fanning S, Cryan B, Glass RI: Rotavirus in Ireland: national estimates of disease burden, 1997 to 1998. Pediatr Infect Dis J. 2001, 20: 693-698. 10.1097/00006454-200107000-00010.PubMed
45.
Fischer TK, Nielsen NM, Wohlfahrt J, Paerregaard A: Incidence and cost of rotavirus hospitalizations in Denmark. Emerg Infect Dis. 2007, 13: 855-859.PubMedPubMedCentral
46.
Kavaliotis I, Papaevangelou V, Aggelakou V, Mantagou L, Trimis G, Papadopoulou V, Vlachaki G, Nikolakopoulou N, Konstantopoulos A: ROTASCORE Study: epidemiological observational study of acute gastroenteritis with or without rotavirus in Greek children younger than 5 years old. Eur J Pediatr. 2008, 167: 707-708. 10.1007/s00431-007-0570-4.PubMed
47.
Flem E, Vainio K, Dollner H, Midgaard C, Bosse FJ, Rognlien AG, Rojahn A, Nordbo SA, Storvold G, Njolstad G, et al: Rotavirus gastroenteritis in Norway: Analysis of prospective surveillance and hospital registry data. Scand J Infect Dis. 2009, 41: 753-759. 10.1080/00365540903161515.PubMed
48.
Van Damme P, Giaquinto C, Maxwell M, Todd P, Van der WM: Distribution of rotavirus genotypes in Europe, 2004-2005: the REVEAL Study. J Infect Dis. 2007, 195 (Suppl 1): S17-S25.PubMed
49.
Fruhwirth M, Brosl S, Ellemunter H, Moll-Schuler I, Rohwedder A, Mutz I: Distribution of rotavirus VP4 genotypes and VP7 serotypes among nonhospitalized and hospitalized patients with gastroenteritis and patients with nosocomially acquired gastroenteritis in Austria. J Clin Microbiol. 2000, 38: 1804-1806.PubMedPubMedCentral
50.
Fischer TK, Eugen-Olsen J, Pedersen AG, Molbak K, Bottiger B, Rostgaard K, Nielsen NM: Characterization of rotavirus strains in a Danish population: high frequency of mixed infections and diversity within the VP4 gene of P[8] strains. J Clin Microbiol. 2005, 43: 1099-1104. 10.1128/JCM.43.3.1099-1104.2005.PubMedPubMedCentral
51.
de Rougemont A, Kaplon J, Lebon P, Huet F, Denis F, Alain S, Fourcade L, Grosjean J, El Hajje MJ, Gendrel D, et al: Unexpected substitution of dominant rotavirus G genotypes in French hospitalized children over five consecutive seasons. Eur J Clin Microbiol Infect Dis. 2009, 28: 403-407. 10.1007/s10096-008-0640-1.PubMed
52.
De Donno A, Grassi T, Bagordo F, Idolo A, Cavallaro A, Gabutti G: Emergence of unusual human rotavirus strains in Salento, Italy, during 2006-2007. BMC Infect Dis. 2009, 9: 43-10.1186/1471-2334-9-43.PubMedPubMedCentral
53.
Ansaldi F, Lai P, Valle L, Riente R, Durando P, Sticchi L, Tucci P, Biasci P, Crovari P, Gasparini R, et al: Burden of rotavirus-associated and non-rotavirus-associated diarrhea among nonhospitalized individuals in central Italy: a 1-year sentinel-based epidemiological and virological surveillance. Clin Infect Dis. 2008, 46: e51-e55. 10.1086/527449.PubMed
54.
Villena C, El Senousy WM, Abad FX, Pinto RM, Bosch A: Group A rotavirus in sewage samples from Barcelona and Cairo: emergence of unusual genotypes. Appl Environ Microbiol. 2003, 69: 3919-3923. 10.1128/AEM.69.7.3919-3923.2003.PubMedPubMedCentral
55.
Iturriza-Gomara M, Elliot AJ, Dockery C, Fleming DM, Gray JJ: Structured surveillance of infectious intestinal disease in pre-school children in the community: 'The Nappy Study'. Epidemiol Infect. 2009, 137: 922-931. 10.1017/S0950268808001556.PubMed
56.
Iturriza Gomara M, Simpson R, Perault AM, Redpath C, Lorgelly P, Joshi D, Mugford M, Hughes CA, Dalrymple J, Desselberger U, et al: Structured surveillance of infantile gastroenteritis in East Anglia, UK: incidence of infection with common viral gastroenteric pathogens. Epidemiol Infect. 2008, 136: 23-33.PubMed
57.
Arista S, Giammanco GM, De Grazia S, Migliore MC, Martella V, Cascio A: Molecular characterization of the genotype G9 human rotavirus strains recovered in Palermo, Italy, during the winter of 1999-2000. Epidemiol Infect. 2004, 132: 343-349. 10.1017/S0950268803001602.PubMedPubMedCentral
58.
Martella V, Terio V, Del Gaudio G, Gentile M, Fiorente P, Barbuti S, Buonavoglia C: Detection of the emerging rotavirus G9 serotype at high frequency in Italy. J Clin Microbiol. 2003, 41: 3960-3963. 10.1128/JCM.41.8.3960-3963.2003.PubMedPubMedCentral
59.
Arista S, Giammanco GM, De Grazia S, Colomba C, Martella V: Genetic variability among serotype G4 Italian human rotaviruses. J Clin Microbiol. 2005, 43: 1420-1425. 10.1128/JCM.43.3.1420-1425.2005.PubMedPubMedCentral
60.
Harrington M, Butler K, Cafferkey M: Rotavirus infection in hospitalised children: incidence and impact on healthcare resources. Ir J Med Sci. 2003, 172: 33-36. 10.1007/BF02914784.PubMed
61.
62.
Martinot A, Hue V, Ego A, Dumonceaux A, Grandbastien B, Guillois B, Leclerc F: Rehydration modalities for acute diarrhea in hospitalized infants. Impact of a permanent short-stay pediatric observation unit. Arch Pediatr. 2001, 8: 1062-1070. 10.1016/S0929-693X(01)00584-X.PubMed
63.
Fourquet F, Desenclos JC, Maurage C, Baron S: Acute gastro-enteritis in children in France: estimates of disease burden through national hospital discharge data. Arch Pediatr. 2003, 10: 861-868. 10.1016/S0929-693X(03)00459-7.PubMed
64.
Bilcke J, Van Damme P, De Smet F, Hanquet G, Van Ranst M, Beutels P: The health and economic burden of rotavirus disease in Belgium. Eur J Pediatr. 2008, 167: 1409-1419. 10.1007/s00431-008-0684-3.PubMed
65.
Panatto D, Amicizia D, Ansaldi F, Marocco A, Marchetti F, Bamfi F, Giacchino R, Tacchella A, Del Buono S, Gasparini R: Burden of rotavirus disease and cost-effectiveness of universal vaccination in the Province of Genoa (Northern Italy). Vaccine. 2009, 27: 3450-3453. 10.1016/j.vaccine.2009.01.054.PubMed
66.
Fruhwirth M, Berger K, Ehlken B, Moll-Schuler I, Brosl S, Mutz I: Economic impact of community- and nosocomially acquired rotavirus gastroenteritis in Austria. Pediatr Infect Dis J. 2001, 20: 184-188. 10.1097/00006454-200102000-00013.PubMed
67.
Bilcke J, Van Damme P, Beutels P: Cost-effectiveness of rotavirus vaccination: exploring caregiver(s) and "no medical care"' disease impact in Belgium. Med Decis Making. 2009, 29: 33-50. 10.1177/0272989X08324955.PubMed
68.
Giaquinto C, Van Damme P, Huet F, Gothefors L, Van der WM: Costs of community-acquired pediatric rotavirus gastroenteritis in 7 European countries: the REVEAL Study. J Infect Dis. 2007, 195 (Suppl 1): S36-S44.PubMed
69.
Huet F, Largeron N, Trichard M, Miadi-Fargier H, Jasso-Mosqueda G: Burden of paediatric rotavirus gastroenteritis and potential benefits of a universal rotavirus vaccination programme with RotaTeq in France. Vaccine. 2007, 25: 6348-6358. 10.1016/j.vaccine.2007.06.015.PubMed
70.
Melliez H, Boelle PY, Baron S, Mouton Y, Yazdanpanah Y: Morbidity and cost of rotavirus infections in France. Med Mal Infect. 2005, 35: 492-499. 10.1016/j.medmal.2005.08.007.PubMed
71.
Sermet-Gaudelus I, de La RF, Salomon JL, Lachassine E, Leruez-Ville M, Baujat G, Trioche P, Valdes L, Parez N, Aujard Y: Rotavirus nosocomial infection in pediatric units. A multicentric observation study. Pathol Biol (Paris). 2004, 52: 4-10. 10.1016/j.patbio.2003.04.002.
72.
Marsella M, Raimondi L, Bergamini M, Sprocati M, Bigi E, De Sanctis V, Borgna-Pignatti C, Gabutti G: Epidemiology of rotavirus-associated hospital admissions in the province of Ferrara, Italy. Eur J Pediatr. 2009, 168: 1423-1427. 10.1007/s00431-009-0942-z.PubMed
73.
Lopez-de-Andres A, Jimenez-Garcia R, Carrasco-Garrido P, Alvaro-Meca A, Galarza PG, de Miguel AG: Hospitalizations associated with rotavirus gastroenteritis in Spain, 2001-2005. BMC Public Health. 2008, 8: 109-10.1186/1471-2458-8-109.PubMedPubMedCentral
74.
Luquero Alcalde FJ, Eiros Bouza JM, Rubio AP, Bachiller Luque MR, Castrodeza Sanz JJ, Ortiz de Lejarazu: Gastroenteritis by rotavirus in Spanish children. Analysis of the disease burden. Eur J Pediatr. 2008, 167: 549-555. 10.1007/s00431-007-0550-8.PubMed
75.
Gil A, Carrasco P, Jimenez R, San Martin M, Oyaguez I, Gonzalez A: Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999-2000. Vaccine. 2004, 22: 2221-2225. 10.1016/j.vaccine.2003.11.037.PubMed
76.
Lorgelly PK, Joshi D, Iturriza GM, Gray J, Mugford M: Exploring the cost effectiveness of an immunization programme for rotavirus gastroenteritis in the United Kingdom. Epidemiol Infect. 2008, 136: 44-55.PubMed
77.
Williams CJ, Lobanov A, Pebody RG: Estimated mortality and hospital admission due to rotavirus infection in the WHO European region. Epidemiol Infect. 2009, 137: 607-616. 10.1017/S0950268808001714.PubMed
78.
Podkolzin AT, Fenske EB, Abramycheva NY, Shipulin GA, Sagalova OI, Mazepa VN, Ivanova GN: Hospital-based surveillance of rotavirus and other viral agents of diarrhea in children and adults in Russia, 2005-2007. J Infect Dis. 2009, 200: S228-S233. 10.1086/605054.PubMed
79.
Phan TG, Yagyu F, Kozlov V, Kozlov A, Okitsu S, Muller WE, Ushijima H: Viral gastroenteritis and genetic characterization of recombinant norovirus circulating in Eastern Russia. Clin Lab. 2006, 52: 247-253.PubMed
80.
Khoury H, Ogilvie I, El Khoury AC, Duan Y, Goetghebeur MM: Burden of rotavirus gastroenteritis in the Middle Eastern and North African pediatric population. BMC Infect Dis. 2011, 11: 9-10.1186/1471-2334-11-9.PubMedPubMedCentral
81.
Diez-Domingo J, Baldo JM, Patrzalek M, Pazdiora P, Forster J, Cantarutti L, Pircon JY, Soriano-Gabarro M, Meyer N: Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries. Eur J Pediatr. 2011, 170: 213-222. 10.1007/s00431-010-1289-1.PubMed
82.
Diez-Domingo J, Surinach NL, Alcalde NM, Betegon L, Largeron N, Trichard M: Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain. BMC Public Health. 2010, 10: 469-10.1186/1471-2458-10-469.PubMedPubMedCentral
83.
Iturriza-Gomara M, Dallman T, Banyai K, Bottiger B, Buesa J, Diedrich S, Fiore L, Johansen K, Koopmans M, Korsun N, et al: Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan-European collaborative strain surveillance network. Epidemiol Infect. 2010, 1-15.
84.
Jit M, Mangen MJ, Melliez H, Yazdanpanah Y, Bilcke J, Salo H, Edmunds WJ, Beutels P: An update to "The cost-effectiveness of rotavirus vaccination: comparative analyses for five European countries and transferability in Europe". Vaccine. 2010, 28: 7457-7459. 10.1016/j.vaccine.2010.08.060.PubMed
85.
Morgan C, Adlard N, Carroll S, Parvataneni L: Burden on UK secondary care of rotavirus disease and seasonal infections in children. Curr Med Res Opin. 2010, 26: 2449-2455. 10.1185/03007995.2010.518135.PubMed
86.
87.
Rahman M, Matthijnssens J, Goegebuer T, De Leener K, Vanderwegen L, Van Der Donck I, Van Hoovels L, De Vos S, Azim T, Van Ranst M: Predominance of rotavirus G9 genotype in children hospitalized for rotavirus gastroenteritis in Belgium during 1999-2003. J Clin Virol. 2005, 33: 1-6. 10.1016/j.jcv.2004.09.020.PubMed
88.
Rosenfeldt V, Vesikari T, Pang XL, Zeng SQ, Tvede M, Paerregaard A: Viral etiology and incidence of acute gastroenteritis in young children attending day-care centers. Pediatr Infect Dis J. 2005, 24: 962-965. 10.1097/01.inf.0000183748.41027.a4.PubMed
89.
Fischer TK: Incidence of hospitalizations due to rotavirus gastroenteritis in Denmark. Acta Paediatr. 2001, 90: 1073-1075. 10.1111/j.1651-2227.2001.tb01366.x.PubMed
90.
Branger B: 2001 national survey of nosocomial infection prevalence among newborns and under-eighteen children and adolescents in France. Arch Pediatr. 2005, 12: 1085-1093. 10.1016/j.arcped.2005.02.011.PubMed
91.
Le Roux P, Marshall B, Toutain F, Mary JF, Pinon G, Briquet E, Le Luyer B: Nosocomial viral infections in a pediatric service: example of rotaviral gastroenteritis and respiratory syncytial viral bronchiolitis. Arch Pediatr. 2004, 11: 908-915. 10.1016/j.arcped.2004.04.022.PubMed
92.
Forster J, Hammerschmidt T: Burden of acute rotavirus gastroenteritis (RV-AGE) in Germany: a comparison of federal statistics and epidemiological data. Gesundheitswesen. 2007, 69: 227-232. 10.1055/s-2007-973090.PubMed
93.
Oh DY, Gaedicke G, Schreier E: Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol. 2003, 71: 82-93. 10.1002/jmv.10449.PubMed
94.
Kafetzis DA, Maltezou HC, Zafeiropoulou A, Attilakos A, Stavrinadis C, Foustoukou M: Epidemiology, clinical course and impact on hospitalization costs of acute diarrhea among hospitalized children in Athens, Greece. Scand J Infect Dis. 2001, 33: 681-685. 10.1080/00365540110026935.PubMed
95.
Palumbo E, Malorgio C, Siani A, Bonora G: Diarrhoea in children: aetiology and clinical aspects. Infez Med. 2009, 17: 95-99.PubMed
96.
Grassi T, De Donno A, Guido M, Gabutti G: The epidemiology and disease burden of rotavirus infection in the Salento peninsula, Italy. Turk J Pediatr. 2008, 50: 132-136.PubMed
97.
Gabutti G, Marsella M, Lazzara C, Fiumana E, Cavallaro A, Borgna-Pignatti C: Epidemiology and burden of rotavirus-associated hospitalizations in Ferrara, Italy. J Prev Med Hyg. 2007, 48: 5-9.PubMed
98.
Koopmans M, Van Asperen I: Epidemiology of rotavirus infections in The Netherlands. Acta Paediatr Suppl. 1999, 88: 31-37.PubMed
99.
Vainio K, Nordbo SA, Njolstad G, Storvold G, Dollner H, Midgaard C, Bosse FJ, Rognlien AG, Rojahn A, Wathne KO, et al: Detection and characterization of group A rotaviruses in children hospitalized with acute gastroenteritis in Norway, 2006-2008. J Med Virol. 2009, 81: 1839-1844. 10.1002/jmv.21576.PubMed
100.
Antunes H, Afonso A, Iturriza M, Martinho I, Ribeiro C, Rocha S, Magalhaes C, Carvalho L, Branca F, Gray J: G2P[4] the most prevalent rotavirus genotype in 2007 winter season in an European non-vaccinated population. J Clin Virol. 2009, 45: 76-78. 10.1016/j.jcv.2009.03.010.PubMed
101.
Rodrigues F, Iturriza M, Gray J, Januario L, Lemos L: Epidemiology of rotavirus in Portugal: G9 as a major cause of diarrhoea in non-hospitalised children. J Clin Virol. 2007, 40: 214-217. 10.1016/j.jcv.2007.08.006.PubMed
102.
Sanchez-Fauquier A, Montero V, Moreno S, Sole M, Colomina J, Iturriza-Gomara M, Revilla A, Wilhelmi I, Gray J: Human rotavirus G9 and G3 as major cause of diarrhea in hospitalized children, Spain. Emerg Infect Dis. 2006, 12: 1536-1541. 10.3201/eid1210.060384.PubMedPubMedCentral
103.
Gil de Miguel A, Carrasco GP, Esteban HJ, San Martin RM, Gonzalez LA: Burden of hospitalizations attributable to rotavirus infection in children in the Autonomous Region of Madrid, Spain, period 1999-2000. An Pediatr (Barc). 2006, 64: 530-535. 10.1157/13089917.
104.
Visser LE, Cano PR, Gay NJ, Martinez Navarro JF: Impact of rotavirus disease in Spain: an estimate of hospital admissions due to rotavirus. Acta Paediatr Suppl. 1999, 88: 72-76.PubMed
105.
Jit M, Pebody R, Chen M, Andrews N, Edmunds WJ: Estimating the number of deaths with rotavirus as a cause in England and wales. Hum Vaccin. 2007, 3: 23-26. 10.4161/hv.3.1.3748.PubMed
106.
Riordan FA, Quigley T: Estimating hospital admissions due to rotavirus gastroenteritis from hospital episode statistics. J Infect. 2004, 49: 13-16. 10.1016/j.jinf.2004.02.006.PubMed
Metadata
Title
Burden of community-acquired and nosocomial rotavirus gastroenteritis in the pediatric population of Western Europe: a scoping review
Authors
Isla Ogilvie
Hanane Khoury
Mireille M Goetghebeur
Antoine C El Khoury
Carlo Giaquinto
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2012
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-12-62

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