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Open Access 01-12-2012 | Research article

Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load

Authors: Sabri Saeed Sanabani, Youko Nukui, Juliana Pereira, Antonio Charlys da Costa, Ana Carolina Soares de Oliveira, Rodrigo Pessôa, Fabio Eudes Leal, Aluisio C Segurado, Esper Georges Kallas, Ester Cerdeira Sabino

Published in: BMC Infectious Diseases | Issue 1/2012

Abstract

Background

The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Methods

In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)).

Results

All 112 samples were successfully genotyped and their PvLs compared. Neither the homozygote TT nor the heterozygote CT mutations nor the combination genotypes (TT/CT) were associated with a greater PvL. We also observed no significant difference in allele distribution between asymptomatic carriers and patients with HTLV-1 associated HAM/TSP.

Conclusions

Our study failed to support the previously reported positive association between the IL28B rs12979860 polymorphisms and an increased risk of developing HAM/TSP in the Brazilian population.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/12/374/prepub

Title: Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load
Authors: Sabri Saeed Sanabani
Youko Nukui
Juliana Pereira
Antonio Charlys da Costa
Ana Carolina Soares de Oliveira
Rodrigo Pessôa
Fabio Eudes Leal
Aluisio C Segurado
Esper Georges Kallas
Ester Cerdeira Sabino
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue 1/2012
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/1471-2334-12-374

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Abstract

Background

Methods

Results

Conclusions

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