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Published in: BMC Geriatrics 1/2014

Open Access 01-12-2014 | Research article

Multimorbidity and long-term care dependency—a five-year follow-up

Authors: Daniela Koller, Gerhard Schön, Ingmar Schäfer, Gerd Glaeske, Hendrik van den Bussche, Heike Hansen

Published in: BMC Geriatrics | Issue 1/2014

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Abstract

Background

Not only single, but also multiple, chronic conditions are becoming the normal situation rather than the exception in the older generation. While many studies show a correlation between multimorbidity and various health outcomes, the long-term effect on care dependency remains unclear. The objective of this study is to follow up a cohort of older adults for 5 years to estimate the impact of multimorbidity on long-term care dependency.

Methods

This study is based on claims data from a German health insurance company. We included 115,203 people (mean age: 71.5 years, 41.4% females). To identify chronic diseases and multimorbidity, we used a defined list of 46 chronic conditions based on ICD-10 codes. Multimorbidity was defined as three or more chronic conditions from this list. The main outcome was “time until long-term care dependency”. The follow-up started on January 1st, 2005 and lasted for 5 years until December 31st, 2009. To evaluate differences between those with multimorbidity and those without, we calculated Kaplan–Meier curves and then modeled four distinct Cox proportional hazard regressions including multimorbidity, age and sex, the single chronic conditions, and disease clusters.

Results

Mean follow-up was 4.5 years. People with multimorbidity had a higher risk of becoming care dependent (HR: 1.85, CI 1.78–1.92). The conditions with the highest risks for long-term care dependency are Parkinson’s disease (HR: 6.40 vs. 2.68) and dementia (HR: 5.70 vs. 2.27). Patients with the multimorbidity pattern “Neuropsychiatric disorders” have a 79% higher risk of care dependency.

Conclusions

The results should form the basis for future health policy decisions on the treatment of patients with multiple chronic diseases and also show the need to introduce new ways of providing long-term care to this population. A health policy focus on chronic care management as well as the development of guidelines for multimorbidity is crucial to secure health services delivery for the older population.
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Literature
1.
go back to reference Kinsella K, He W: U.S. Census Bureau, International Population Reports, P95/09-1, An Aging World: 2008. 2009, Washington, DC: U.S. Government Printing Office Kinsella K, He W: U.S. Census Bureau, International Population Reports, P95/09-1, An Aging World: 2008. 2009, Washington, DC: U.S. Government Printing Office
2.
go back to reference Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B: Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012, 380: 37-43. 10.1016/S0140-6736(12)60240-2.CrossRefPubMed Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B: Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012, 380: 37-43. 10.1016/S0140-6736(12)60240-2.CrossRefPubMed
3.
go back to reference Salisbury C: Multimorbidity: redesigning health care for people who use it. Lancet. 2012, 380: 7-9. 10.1016/S0140-6736(12)60482-6.CrossRefPubMed Salisbury C: Multimorbidity: redesigning health care for people who use it. Lancet. 2012, 380: 7-9. 10.1016/S0140-6736(12)60482-6.CrossRefPubMed
4.
go back to reference Campbell-Scherer D: Multimorbidity: a challenge for evidence-based medicine. Evid Based Med. 2010, 15: 165-166. 10.1136/ebm1154.CrossRefPubMed Campbell-Scherer D: Multimorbidity: a challenge for evidence-based medicine. Evid Based Med. 2010, 15: 165-166. 10.1136/ebm1154.CrossRefPubMed
5.
go back to reference Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L: Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011, 10: 430-439. 10.1016/j.arr.2011.03.003.CrossRefPubMed Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L: Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011, 10: 430-439. 10.1016/j.arr.2011.03.003.CrossRefPubMed
6.
go back to reference Fortin M, Stewart M, Poitras M-E, Almirall J, Maddocks H: A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012, 10: 142-151. 10.1370/afm.1337.CrossRefPubMedPubMedCentral Fortin M, Stewart M, Poitras M-E, Almirall J, Maddocks H: A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012, 10: 142-151. 10.1370/afm.1337.CrossRefPubMedPubMedCentral
7.
go back to reference Formiga F, Ferrer A, Sanz H, Marengoni A, Alburquerque J, Pujol R: Patterns of comorbidity and multimorbidity in the oldest old: the Octabaix study. Eur J Intern Med. 2012, 24: 40-44.CrossRefPubMed Formiga F, Ferrer A, Sanz H, Marengoni A, Alburquerque J, Pujol R: Patterns of comorbidity and multimorbidity in the oldest old: the Octabaix study. Eur J Intern Med. 2012, 24: 40-44.CrossRefPubMed
9.
go back to reference Fried TR, Tinetti ME, Iannone L, O’Leary JR, Towle V, Van Ness PH: Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Arch Intern Med. 2011, 171: 1854-6. 10.1001/archinternmed.2011.512.CrossRefPubMedPubMedCentral Fried TR, Tinetti ME, Iannone L, O’Leary JR, Towle V, Van Ness PH: Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Arch Intern Med. 2011, 171: 1854-6. 10.1001/archinternmed.2011.512.CrossRefPubMedPubMedCentral
10.
go back to reference Tinetti ME, Bogardus ST, Agostini JV: Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med. 2004, 351: 2870-2874. 10.1056/NEJMsb042458.CrossRefPubMed Tinetti ME, Bogardus ST, Agostini JV: Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med. 2004, 351: 2870-2874. 10.1056/NEJMsb042458.CrossRefPubMed
11.
go back to reference Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005, 294: 716-724. 10.1001/jama.294.6.716.CrossRefPubMed Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW: Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005, 294: 716-724. 10.1001/jama.294.6.716.CrossRefPubMed
12.
go back to reference Hughes LD, McMurdo METT, Guthrie B: Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing. 2012, 42: 62-9.CrossRefPubMed Hughes LD, McMurdo METT, Guthrie B: Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing. 2012, 42: 62-9.CrossRefPubMed
13.
go back to reference Van Weel C, Schellevis FG: Comorbidity and guidelines: conflicting interests. Lancet. 2006, 367: 550-1. 10.1016/S0140-6736(06)68198-1.CrossRefPubMed Van Weel C, Schellevis FG: Comorbidity and guidelines: conflicting interests. Lancet. 2006, 367: 550-1. 10.1016/S0140-6736(06)68198-1.CrossRefPubMed
14.
go back to reference Roland M, Paddison C: Better management of patients with multimorbidity. 2013, 2510 (May): 2-5. May Roland M, Paddison C: Better management of patients with multimorbidity. 2013, 2510 (May): 2-5. May
15.
go back to reference Tinetti ME, McAvay GJ, Chang SS, Newman AB, Fitzpatrick AL, Fried TR, Peduzzi PN: Contribution of multiple chronic conditions to universal health outcomes. J Am Geriatr Soc. 2011, 59: 1686-91. 10.1111/j.1532-5415.2011.03573.x.CrossRefPubMedPubMedCentral Tinetti ME, McAvay GJ, Chang SS, Newman AB, Fitzpatrick AL, Fried TR, Peduzzi PN: Contribution of multiple chronic conditions to universal health outcomes. J Am Geriatr Soc. 2011, 59: 1686-91. 10.1111/j.1532-5415.2011.03573.x.CrossRefPubMedPubMedCentral
16.
go back to reference Salisbury C, Johnson L, Purdy S, Valderas JM, Montgomery AA: Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. Br J Gen Pract. 2011, 61: e12-21. 10.3399/bjgp11X548929.CrossRefPubMed Salisbury C, Johnson L, Purdy S, Valderas JM, Montgomery AA: Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. Br J Gen Pract. 2011, 61: e12-21. 10.3399/bjgp11X548929.CrossRefPubMed
17.
go back to reference Tooth L, Hockey R, Byles J, Dobson A: Weighted multimorbidity indexes predicted mortality, health service use, and health-related quality of life in older women. J Clin Epidemiol. 2008, 61: 151-9. 10.1016/j.jclinepi.2007.05.015.CrossRefPubMed Tooth L, Hockey R, Byles J, Dobson A: Weighted multimorbidity indexes predicted mortality, health service use, and health-related quality of life in older women. J Clin Epidemiol. 2008, 61: 151-9. 10.1016/j.jclinepi.2007.05.015.CrossRefPubMed
18.
go back to reference Menotti A, Mulder I, Nissinen A, Giampaoli S, Feskens EJ, Kromhout M, Kromhout T: Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: the FINE study (Finland, Italy, Netherlands, Elderly). J Clin Epidemiol. 2001, 54: 680-6. 10.1016/S0895-4356(00)00368-1.CrossRefPubMed Menotti A, Mulder I, Nissinen A, Giampaoli S, Feskens EJ, Kromhout M, Kromhout T: Prevalence of morbidity and multimorbidity in elderly male populations and their impact on 10-year all-cause mortality: the FINE study (Finland, Italy, Netherlands, Elderly). J Clin Epidemiol. 2001, 54: 680-6. 10.1016/S0895-4356(00)00368-1.CrossRefPubMed
19.
go back to reference Byles JE, D’Este C, Parkinson L, O’Connell R, Treloar C: Single index of multimorbidity did not predict multiple outcomes. J Clin Epidemiol. 2005, 58: 997-1005. 10.1016/j.jclinepi.2005.02.025.CrossRefPubMed Byles JE, D’Este C, Parkinson L, O’Connell R, Treloar C: Single index of multimorbidity did not predict multiple outcomes. J Clin Epidemiol. 2005, 58: 997-1005. 10.1016/j.jclinepi.2005.02.025.CrossRefPubMed
20.
go back to reference Landi F, Liperoti R, Russo A, Capoluongo E, Barillaro C, Pahor M, Bernabei R, Onder G: Disability, more than multimorbidity, was predictive of mortality among older persons aged 80 years and older. J Clin Epidemiol. 2010, 63: 752-9. 10.1016/j.jclinepi.2009.09.007.CrossRefPubMed Landi F, Liperoti R, Russo A, Capoluongo E, Barillaro C, Pahor M, Bernabei R, Onder G: Disability, more than multimorbidity, was predictive of mortality among older persons aged 80 years and older. J Clin Epidemiol. 2010, 63: 752-9. 10.1016/j.jclinepi.2009.09.007.CrossRefPubMed
21.
go back to reference Marengoni A, von Strauss E, Rizzuto D, Winblad B, Fratiglioni L: The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med. 2009, 265: 288-95. 10.1111/j.1365-2796.2008.02017.x.CrossRefPubMed Marengoni A, von Strauss E, Rizzuto D, Winblad B, Fratiglioni L: The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med. 2009, 265: 288-95. 10.1111/j.1365-2796.2008.02017.x.CrossRefPubMed
22.
go back to reference Akner G: Analysis of multimorbidity in individual elderly nursing home residents. Development of a multimorbidity matrix. Arch Gerontol Geriatr. 2009, 49: 413-9. 10.1016/j.archger.2008.12.009.CrossRefPubMed Akner G: Analysis of multimorbidity in individual elderly nursing home residents. Development of a multimorbidity matrix. Arch Gerontol Geriatr. 2009, 49: 413-9. 10.1016/j.archger.2008.12.009.CrossRefPubMed
23.
go back to reference Schram MT, Frijters D, Ploemacher J, Craen AJM, Waal MWM D, Rooij FJ V, Heeringa J, Hofman A, Deeg DJH, Schellevis FG, Schellevis FG: Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. Eur J Public Health. 2008, 61: 1104-1112. Schram MT, Frijters D, Ploemacher J, Craen AJM, Waal MWM D, Rooij FJ V, Heeringa J, Hofman A, Deeg DJH, Schellevis FG, Schellevis FG: Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. Eur J Public Health. 2008, 61: 1104-1112.
24.
go back to reference Marengoni A, Angleman S: Prevalence of disability according to multimorbidity and disease clustering: a population-based study. J Comorbidity. 2011, 1: 11-18.CrossRef Marengoni A, Angleman S: Prevalence of disability according to multimorbidity and disease clustering: a population-based study. J Comorbidity. 2011, 1: 11-18.CrossRef
25.
go back to reference Wolff JL, Boult C, Boyd CM, Anderson G: Newly reported chronic conditions and onset of functional dependency. J Am Geriatr Soc. 2005, 53: 851-5. 10.1111/j.1532-5415.2005.53262.x.CrossRefPubMed Wolff JL, Boult C, Boyd CM, Anderson G: Newly reported chronic conditions and onset of functional dependency. J Am Geriatr Soc. 2005, 53: 851-5. 10.1111/j.1532-5415.2005.53262.x.CrossRefPubMed
27.
go back to reference Van den Bussche H, Koller D, Kolonko T, Hansen H, Wegscheider K, Glaeske G, von Leitner E-C, Schäfer I, Schön G: Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health. 2011, 11: 101-10.1186/1471-2458-11-101.CrossRefPubMedPubMedCentral Van den Bussche H, Koller D, Kolonko T, Hansen H, Wegscheider K, Glaeske G, von Leitner E-C, Schäfer I, Schön G: Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health. 2011, 11: 101-10.1186/1471-2458-11-101.CrossRefPubMedPubMedCentral
28.
go back to reference Schäfer I, von Leitner E-C, Schön G, Koller D, Hansen H, Kolonko T, Kaduszkiewicz H, Wegscheider K, Glaeske G, van den Bussche H: Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One. 2010, 5: e15941-10.1371/journal.pone.0015941.CrossRefPubMedPubMedCentral Schäfer I, von Leitner E-C, Schön G, Koller D, Hansen H, Kolonko T, Kaduszkiewicz H, Wegscheider K, Glaeske G, van den Bussche H: Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One. 2010, 5: e15941-10.1371/journal.pone.0015941.CrossRefPubMedPubMedCentral
29.
go back to reference Sousa RM, Ferri CP, Acosta D, Albanese E, Guerra M, Huang Y, Jacob KS, Jotheeswaran AT, Rodriguez JJL, Pichardo GR, Rodriguez MC, Salas A, Sosa AL, Williams J, Zuniga T, Prince MJ: Contribution of chronic diseases to disability in elderly people in countries with low and middle incomes: a 10/66 Dementia Research Group population-based survey. Lancet. 2009, 374: 1821-30. 10.1016/S0140-6736(09)61829-8.CrossRefPubMedPubMedCentral Sousa RM, Ferri CP, Acosta D, Albanese E, Guerra M, Huang Y, Jacob KS, Jotheeswaran AT, Rodriguez JJL, Pichardo GR, Rodriguez MC, Salas A, Sosa AL, Williams J, Zuniga T, Prince MJ: Contribution of chronic diseases to disability in elderly people in countries with low and middle incomes: a 10/66 Dementia Research Group population-based survey. Lancet. 2009, 374: 1821-30. 10.1016/S0140-6736(09)61829-8.CrossRefPubMedPubMedCentral
30.
go back to reference Sousa RM, Ferri CP, Acosta D, Guerra M, Huang Y, Jacob KS, Jotheeswaran AT, Hernandez MG, Prince MJ: The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey. BMC Geriatr. 2010, 10: 53-10.1186/1471-2318-10-53.CrossRefPubMedPubMedCentral Sousa RM, Ferri CP, Acosta D, Guerra M, Huang Y, Jacob KS, Jotheeswaran AT, Hernandez MG, Prince MJ: The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey. BMC Geriatr. 2010, 10: 53-10.1186/1471-2318-10-53.CrossRefPubMedPubMedCentral
31.
go back to reference Luck T, Luppa M, Weber S, Matschinger H, Glaesmer H, König H-H, Angermeyer MC, Riedel-Heller SG: Time until institutionalization in incident dementia cases–results of the Leipzig Longitudinal Study of the Aged (LEILA 75+). Neuroepidemiology. 2008, 31: 100-8. 10.1159/000146251.CrossRefPubMed Luck T, Luppa M, Weber S, Matschinger H, Glaesmer H, König H-H, Angermeyer MC, Riedel-Heller SG: Time until institutionalization in incident dementia cases–results of the Leipzig Longitudinal Study of the Aged (LEILA 75+). Neuroepidemiology. 2008, 31: 100-8. 10.1159/000146251.CrossRefPubMed
32.
go back to reference Boult C, Kane RL, Louis TA, Boult L, McCaffrey D: Chronic conditions that lead to functional limitation in the elderly. J Gerontol. 1994, 49: M28-36. 10.1093/geronj/49.1.M28.CrossRefPubMed Boult C, Kane RL, Louis TA, Boult L, McCaffrey D: Chronic conditions that lead to functional limitation in the elderly. J Gerontol. 1994, 49: M28-36. 10.1093/geronj/49.1.M28.CrossRefPubMed
33.
34.
go back to reference De Groot V, Beckerman H, Lankhorst GJ, Bouter LM: How to measure comorbidity. A critical review of available methods. J Clin Epidemiol. 2003, 56: 221-9. 10.1016/S0895-4356(02)00585-1.CrossRefPubMed De Groot V, Beckerman H, Lankhorst GJ, Bouter LM: How to measure comorbidity. A critical review of available methods. J Clin Epidemiol. 2003, 56: 221-9. 10.1016/S0895-4356(02)00585-1.CrossRefPubMed
35.
go back to reference Le Reste JY, Nabbe P, Manceau B, Lygidakis C, Doerr C, Lingner H, Czachowski S, Munoz M, Argyriadou S, Claveria A, Le Floch B, Barais M, Bower P, Van Marwijk H, Van Royen P, Lietard C: The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long term care, following a systematic review of relevant literature. J Am Med Dir Assoc. 2013, 14: 319-25. 10.1016/j.jamda.2013.01.001.CrossRefPubMed Le Reste JY, Nabbe P, Manceau B, Lygidakis C, Doerr C, Lingner H, Czachowski S, Munoz M, Argyriadou S, Claveria A, Le Floch B, Barais M, Bower P, Van Marwijk H, Van Royen P, Lietard C: The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long term care, following a systematic review of relevant literature. J Am Med Dir Assoc. 2013, 14: 319-25. 10.1016/j.jamda.2013.01.001.CrossRefPubMed
36.
go back to reference Riedel-Heller SG, Busse A, Angermeyer MC: Are cognitively impaired individuals adequately represented in community surveys? Recruitment challenges and strategies to facilitate participation in community surveys of older adults. A review Eur J Epidemiol. 2000, 16: 827-35. 10.1023/A:1007615119222.CrossRefPubMed Riedel-Heller SG, Busse A, Angermeyer MC: Are cognitively impaired individuals adequately represented in community surveys? Recruitment challenges and strategies to facilitate participation in community surveys of older adults. A review Eur J Epidemiol. 2000, 16: 827-35. 10.1023/A:1007615119222.CrossRefPubMed
Metadata
Title
Multimorbidity and long-term care dependency—a five-year follow-up
Authors
Daniela Koller
Gerhard Schön
Ingmar Schäfer
Gerd Glaeske
Hendrik van den Bussche
Heike Hansen
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2014
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/1471-2318-14-70

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