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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2010

Open Access 01-12-2010 | Research article

Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study

Authors: Daniele Campa, Barbara Pardini, Alessio Naccarati, Ludmila Vodickova, Jan Novotny, Verena Steinke, Nils Rahner, Elke Holinski-Feder, Monika Morak, Hans K Schackert, Heike Görgens, Judith Kötting, Beate Betz, Matthias Kloor, Christoph Engel, Reinhard Büttner, Peter Propping, Asta Försti, Kari Hemminki, Roberto Barale, Pavel Vodicka, Federico Canzian

Published in: BMC Gastroenterology | Issue 1/2010

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Abstract

Background

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development.

Methods

We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic.

Results

We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany.

Conclusion

A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).
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Metadata
Title
Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
Authors
Daniele Campa
Barbara Pardini
Alessio Naccarati
Ludmila Vodickova
Jan Novotny
Verena Steinke
Nils Rahner
Elke Holinski-Feder
Monika Morak
Hans K Schackert
Heike Görgens
Judith Kötting
Beate Betz
Matthias Kloor
Christoph Engel
Reinhard Büttner
Peter Propping
Asta Försti
Kari Hemminki
Roberto Barale
Pavel Vodicka
Federico Canzian
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2010
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/1471-230X-10-112

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