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BMC Medical Research Methodology

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Open Access 01-12-2001 | Research article

Sample size requirements for case-control study designs

Author: Michael D Edwardes

Published in: BMC Medical Research Methodology | Issue 1/2001

Abstract

Background

Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.

Results

The formulas are extended from one control per case to F controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored.

Conclusions

Software is now available for computing adjusted sample sizes for case-control designs.

Available only for authorised users

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2288/1/11/prepub

Title: Sample size requirements for case-control study designs
Author: Michael D Edwardes
Publication date: 01-12-2001
Publisher: BioMed Central
Published in: BMC Medical Research Methodology / Issue 1/2001
Electronic ISSN: 1471-2288
DOI: https://doi.org/10.1186/1471-2288-1-11

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Sample size requirements for case-control study designs

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Results

Conclusions

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