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Published in: BMC Anesthesiology 1/2015

Open Access 01-12-2015 | Research article

Cardiac surgery in 260 octogenarians: a case series

Authors: Anna Mara Scandroglio, Gabriele Finco, Marina Pieri, Roberto Ascari, Maria Grazia Calabrò, Daiana Taddeo, Francesca Isella, Annalisa Franco, Mario Musu, Giovanni Landoni, Ottavio Alfieri, Alberto Zangrillo

Published in: BMC Anesthesiology | Issue 1/2015

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Abstract

Background

The elderly undergo cardiac surgery more and more frequently, often present multiple comorbidities, assume chronic therapies, and present a unique physiology. Aim of our study was to analyze the experience of a referral cardiac surgery center with all types of cardiac surgery interventions performed in patients ≥80 years old over a six years’ period.

Methods

A retrospective observational study performed in a university hospital. 260 patients were included in the study (3.5% of the patients undergoing cardiac surgery in the study period).

Results

Mean age was 82 ± 1.8 years. Eighty-five percent of patients underwent elective surgery, 15% unplanned surgery and 4.2% redo surgery. Intervention for aortic valve pathology and coronary artery bypass grafting were performed in 51% and 46% of the patients, respectively. Interventions involving the mitral valve were the 26% of the total, those on the tricuspid valve were 13% and those on the ascending aortic arch the 9.6%. Postoperative low output syndrome was identified in 44 patients (17%). Mortality was 3.9% and most of the patients (91%) were discharged from hospital in good clinical conditions. Hospital mortality was lower in planned vs unplanned surgery: 3.8% vs 14% respectively. Chronic obstructive pulmonary disease (OR 9.106, CI 2.275 – 36.450) was the unique independent predictor of mortality.

Conclusions

Clinicians should be aware that cardiac surgery can be safely performed at all ages, that risk stratification is mandatory and that hemodynamic treatment to avoid complications is expected.
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Literature
1.
2.
go back to reference Geokas MC, Lakatta EG, Makinodan T, Timiras PS: The aging process.Ann Intern Med 1990, 113:455–66. 10.7326/0003-4819-113-6-455CrossRefPubMed Geokas MC, Lakatta EG, Makinodan T, Timiras PS: The aging process.Ann Intern Med 1990, 113:455–66. 10.7326/0003-4819-113-6-455CrossRefPubMed
3.
go back to reference Wk F, Schaff HV, O’Brian PC, Orszulak TA, Naessens JM, Tajik AJ: Cardiac outcome in the octogenarian: perioperative outcome and clinical follow-up.J Am Coll Cardiol 1991,18(1):29–35. 10.1016/S0735-1097(10)80212-8CrossRef Wk F, Schaff HV, O’Brian PC, Orszulak TA, Naessens JM, Tajik AJ: Cardiac outcome in the octogenarian: perioperative outcome and clinical follow-up.J Am Coll Cardiol 1991,18(1):29–35. 10.1016/S0735-1097(10)80212-8CrossRef
4.
go back to reference Edmunds LH, Stephenson LW, Edie RN, Ratcliffe MB: Open-heart surgery in octogenarians.N Engl J Med 1988, 319:131–6. 10.1056/NEJM198807213190302CrossRefPubMed Edmunds LH, Stephenson LW, Edie RN, Ratcliffe MB: Open-heart surgery in octogenarians.N Engl J Med 1988, 319:131–6. 10.1056/NEJM198807213190302CrossRefPubMed
5.
go back to reference Song HK, Diggs BS, Slater MS, Guyton SW, Ungerleider RM, Welke KF: Improved quality and cost-effectiveness of coronary artery bypass grafting in the United States from 1988–2005.J Thorac Cardiovasc Surg 2009, 137:65–9. 10.1016/j.jtcvs.2008.09.053CrossRefPubMed Song HK, Diggs BS, Slater MS, Guyton SW, Ungerleider RM, Welke KF: Improved quality and cost-effectiveness of coronary artery bypass grafting in the United States from 1988–2005.J Thorac Cardiovasc Surg 2009, 137:65–9. 10.1016/j.jtcvs.2008.09.053CrossRefPubMed
6.
go back to reference Thygesen K, Alpert JS, White HD, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefition of Myocardial Infarction: Universal definition of myocardial infarction.Circulation 2007, 116:2634–53. 10.1161/CIRCULATIONAHA.107.187397CrossRefPubMed Thygesen K, Alpert JS, White HD, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefition of Myocardial Infarction: Universal definition of myocardial infarction.Circulation 2007, 116:2634–53. 10.1161/CIRCULATIONAHA.107.187397CrossRefPubMed
7.
go back to reference Prondzinsky R, Unverzagt S, Russ M, Lemm H, Swyter M, Wegener N, et al.: Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP shock trial.Shock 2012,37(4):378–84. doi:10.1097/SHK.0b013e31824a67af 10.1097/SHK.0b013e31824a67afCrossRefPubMed Prondzinsky R, Unverzagt S, Russ M, Lemm H, Swyter M, Wegener N, et al.: Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP shock trial.Shock 2012,37(4):378–84. doi:10.1097/SHK.0b013e31824a67af 10.1097/SHK.0b013e31824a67afCrossRefPubMed
8.
go back to reference Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.Crit Care 2004,8(4):R204–12. 10.1186/cc2872CrossRefPubMedPubMedCentral Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.Crit Care 2004,8(4):R204–12. 10.1186/cc2872CrossRefPubMedPubMedCentral
9.
go back to reference Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine.Nephron 1976, 16:31–41. 10.1159/000180580CrossRefPubMed Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine.Nephron 1976, 16:31–41. 10.1159/000180580CrossRefPubMed
10.
go back to reference Ranucci M, Castelvecchio S, Conte M, Megliola G, Speziale G, Fiore F, et al.: The easier, the better: age, creatinine, ejection fraction score for operative mortality risk stratification in a series of 29,659 patients undergoing elective cardiac surgery.J Thorac Cardiovasc Surg 2011,142(3):581–6. doi:10.1016/j.jtcvs.2010.11.064 10.1016/j.jtcvs.2010.11.064CrossRefPubMed Ranucci M, Castelvecchio S, Conte M, Megliola G, Speziale G, Fiore F, et al.: The easier, the better: age, creatinine, ejection fraction score for operative mortality risk stratification in a series of 29,659 patients undergoing elective cardiac surgery.J Thorac Cardiovasc Surg 2011,142(3):581–6. doi:10.1016/j.jtcvs.2010.11.064 10.1016/j.jtcvs.2010.11.064CrossRefPubMed
12.
go back to reference Bridges CR, Edwards FH, Peterson ED, Coombs LP, Ferguson TB: Cardiac surgery in nonagenarians and centenarians.J Am Coll Surg 2003,197(3):347–56. 10.1016/S1072-7515(03)00384-3CrossRefPubMed Bridges CR, Edwards FH, Peterson ED, Coombs LP, Ferguson TB: Cardiac surgery in nonagenarians and centenarians.J Am Coll Surg 2003,197(3):347–56. 10.1016/S1072-7515(03)00384-3CrossRefPubMed
13.
go back to reference Biancari F, Schifano P, Pighi M, Vasques F, Juvonen T, Vinco G: Pooled estimates of immediate and late outcome of mitral valve surgery in octogenarians: a meta-analysis and meta-regression.J Cardiothorac Vasc Anesth 2013,27(2):213–9. 10.1053/j.jvca.2012.11.007CrossRefPubMed Biancari F, Schifano P, Pighi M, Vasques F, Juvonen T, Vinco G: Pooled estimates of immediate and late outcome of mitral valve surgery in octogenarians: a meta-analysis and meta-regression.J Cardiothorac Vasc Anesth 2013,27(2):213–9. 10.1053/j.jvca.2012.11.007CrossRefPubMed
14.
go back to reference Ferguson BT, Hammill BG, Peterson ED, DeLong ER, Grover FL, STS National Database Committee: A decade of change: risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990–1999 – a report from the STS National Database Committee and the Duke Clinical Research Institute.Ann Thorac Surg 2002,73(2):480–9. 10.1016/S0003-4975(01)03339-2CrossRefPubMed Ferguson BT, Hammill BG, Peterson ED, DeLong ER, Grover FL, STS National Database Committee: A decade of change: risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990–1999 – a report from the STS National Database Committee and the Duke Clinical Research Institute.Ann Thorac Surg 2002,73(2):480–9. 10.1016/S0003-4975(01)03339-2CrossRefPubMed
15.
go back to reference Paparella D, Brister SJ, Buchanan MR: Coagulation disorders of cardiopulmonary bypass: a review.Intensive Care Med 2004,30(10):1873–81. 10.1007/s00134-004-2388-0CrossRefPubMed Paparella D, Brister SJ, Buchanan MR: Coagulation disorders of cardiopulmonary bypass: a review.Intensive Care Med 2004,30(10):1873–81. 10.1007/s00134-004-2388-0CrossRefPubMed
16.
go back to reference Warren OJ, Smith AJ, Alexiou C, Rogers PL, Jawad N, Vincent C, et al.: The inflammatory response to cardiopulmonary bypass: part 1–mechanisms of pathogenesis.J Cardiothorac Vasc Anesth 2009,23(2):223–31. 10.1053/j.jvca.2008.08.007CrossRefPubMed Warren OJ, Smith AJ, Alexiou C, Rogers PL, Jawad N, Vincent C, et al.: The inflammatory response to cardiopulmonary bypass: part 1–mechanisms of pathogenesis.J Cardiothorac Vasc Anesth 2009,23(2):223–31. 10.1053/j.jvca.2008.08.007CrossRefPubMed
17.
go back to reference Zangrillo A, Crescenzi G, Landoni G, Leoni A, Marino G, Calabrò MG, et al.: Off-pump coronary artery bypass grafting reduces postoperative neurologic complications compared to CPB.J Cardiothorac Vasc Anesth 2005,19(2):193–6. 10.1053/j.jvca.2005.01.030CrossRefPubMed Zangrillo A, Crescenzi G, Landoni G, Leoni A, Marino G, Calabrò MG, et al.: Off-pump coronary artery bypass grafting reduces postoperative neurologic complications compared to CPB.J Cardiothorac Vasc Anesth 2005,19(2):193–6. 10.1053/j.jvca.2005.01.030CrossRefPubMed
18.
go back to reference Hemmerling TM, Romano G, Terrasini N, Noiseux N: Anesthesia for off-pump coronary artery bypass surgery.Ann Card Anaesh 2013,16(1):28–39. 10.4103/0971-9784.105367CrossRef Hemmerling TM, Romano G, Terrasini N, Noiseux N: Anesthesia for off-pump coronary artery bypass surgery.Ann Card Anaesh 2013,16(1):28–39. 10.4103/0971-9784.105367CrossRef
19.
go back to reference Abdel-Wahab M, Zahn R, Horack M, Gerckens U, Schuler G, Sievert H, et al.: Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.Clin Res Cardiol 2012,101(12):973–81. 10.1007/s00392-012-0486-5CrossRefPubMed Abdel-Wahab M, Zahn R, Horack M, Gerckens U, Schuler G, Sievert H, et al.: Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.Clin Res Cardiol 2012,101(12):973–81. 10.1007/s00392-012-0486-5CrossRefPubMed
20.
go back to reference Blackman DJ, Baxter PD, Gale CP, Moat NE, Maccarthy PA, Hildick-Smith D, et al.: Do outcomes from transcatheter aortic valve implantation vary according to access route and valve type? The UK TAVI Registry.J Interv Cardiol 2014,27(1):86–95. 10.1111/joic.12084CrossRefPubMed Blackman DJ, Baxter PD, Gale CP, Moat NE, Maccarthy PA, Hildick-Smith D, et al.: Do outcomes from transcatheter aortic valve implantation vary according to access route and valve type? The UK TAVI Registry.J Interv Cardiol 2014,27(1):86–95. 10.1111/joic.12084CrossRefPubMed
21.
go back to reference Wenaweser P, Stortecky S, Heg D, Tueller D, Nietlispach F, Falk V, et al.: Short-term clinical outcomes among patients undergoing transcatheter aortic valve implantation in Switzerland: the Swiss TAVI registry.EuroIntervention 2014. In press Wenaweser P, Stortecky S, Heg D, Tueller D, Nietlispach F, Falk V, et al.: Short-term clinical outcomes among patients undergoing transcatheter aortic valve implantation in Switzerland: the Swiss TAVI registry.EuroIntervention 2014. In press
22.
go back to reference Alfieri O, Pozzoli A: Mitral valve surgery in octogenarians: insights and perspectives.J Cardiothorac Vasc Anesth 2013,27(2):201–2. 10.1053/j.jvca.2013.01.001CrossRefPubMed Alfieri O, Pozzoli A: Mitral valve surgery in octogenarians: insights and perspectives.J Cardiothorac Vasc Anesth 2013,27(2):201–2. 10.1053/j.jvca.2013.01.001CrossRefPubMed
23.
go back to reference Zangrillo A, Sparicio D, Crivellari M, Aletti G, Bove T, Mamo D, et al.: Low perioperative mortality for cardiac surgery in octogenarians.Minerva Anestesiol 2004,70(10):717–23. 723–726PubMed Zangrillo A, Sparicio D, Crivellari M, Aletti G, Bove T, Mamo D, et al.: Low perioperative mortality for cardiac surgery in octogenarians.Minerva Anestesiol 2004,70(10):717–23. 723–726PubMed
24.
go back to reference Landoni G, Gonfalini M, Zangrillo A: Safety of cardiac surgery in octogenarians and nonagenarians.J Cardiothorac Vasc Anesth 2008,22(4):646–7. 10.1053/j.jvca.2008.01.005CrossRefPubMed Landoni G, Gonfalini M, Zangrillo A: Safety of cardiac surgery in octogenarians and nonagenarians.J Cardiothorac Vasc Anesth 2008,22(4):646–7. 10.1053/j.jvca.2008.01.005CrossRefPubMed
25.
go back to reference Bignami E, Biondi-Zoccai G, Landoni G, Fochi O, Testa V, Shaiban I, et al.: Volatile anesthetics reduce mortality in cardiac surgery.J Cardiothorac Vasc Anesth 2009,23(5):594–9. 10.1053/j.jvca.2009.01.022CrossRefPubMed Bignami E, Biondi-Zoccai G, Landoni G, Fochi O, Testa V, Shaiban I, et al.: Volatile anesthetics reduce mortality in cardiac surgery.J Cardiothorac Vasc Anesth 2009,23(5):594–9. 10.1053/j.jvca.2009.01.022CrossRefPubMed
26.
go back to reference Olper L, Cabrini L, Landoni G, Rossodivita A, Nobile L, Monti G, et al.: Non-invasive ventilation after cardiac surgery outside the intensive care unit.Minerva Anestesiol 2011,77(1):40–5.PubMed Olper L, Cabrini L, Landoni G, Rossodivita A, Nobile L, Monti G, et al.: Non-invasive ventilation after cardiac surgery outside the intensive care unit.Minerva Anestesiol 2011,77(1):40–5.PubMed
27.
go back to reference Gjeilo KH, Wahba A, Klepstad P, Lydersen S, Stenseth R: Survival and quality of life in an elderly cardiac surgery population: 5-year follow-up.Eur J Cardiothorac Surg Eur J Cardiothorac Surg 2013,44(3):e182–8. 10.1093/ejcts/ezt308CrossRefPubMed Gjeilo KH, Wahba A, Klepstad P, Lydersen S, Stenseth R: Survival and quality of life in an elderly cardiac surgery population: 5-year follow-up.Eur J Cardiothorac Surg Eur J Cardiothorac Surg 2013,44(3):e182–8. 10.1093/ejcts/ezt308CrossRefPubMed
28.
go back to reference Khan D, Mukherjee S, Sarkar S, Kumar V, Charles EV: Cardiac surgery in octogenarians.J Indian Med Assoc 2012,110(9):662–3.PubMed Khan D, Mukherjee S, Sarkar S, Kumar V, Charles EV: Cardiac surgery in octogenarians.J Indian Med Assoc 2012,110(9):662–3.PubMed
29.
go back to reference Deschka H, Schreier R, El-Ayoubi L, Erler S, Müller D, Alken A, et al.: Prolonged intensive care treatment of octogenarians after cardiac surgery: a reasonable economic burden?Interact Cardiovasc Thorac Surg 2013,17(3):501–6. 10.1093/icvts/ivt229CrossRefPubMedPubMedCentral Deschka H, Schreier R, El-Ayoubi L, Erler S, Müller D, Alken A, et al.: Prolonged intensive care treatment of octogenarians after cardiac surgery: a reasonable economic burden?Interact Cardiovasc Thorac Surg 2013,17(3):501–6. 10.1093/icvts/ivt229CrossRefPubMedPubMedCentral
30.
go back to reference Mézière A, Paillaud E, Plaud B: Anesthesia in the elderly.Presse Med 2013,42(2):197–201. 10.1016/j.lpm.2012.07.040CrossRefPubMed Mézière A, Paillaud E, Plaud B: Anesthesia in the elderly.Presse Med 2013,42(2):197–201. 10.1016/j.lpm.2012.07.040CrossRefPubMed
Metadata
Title
Cardiac surgery in 260 octogenarians: a case series
Authors
Anna Mara Scandroglio
Gabriele Finco
Marina Pieri
Roberto Ascari
Maria Grazia Calabrò
Daiana Taddeo
Francesca Isella
Annalisa Franco
Mario Musu
Giovanni Landoni
Ottavio Alfieri
Alberto Zangrillo
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2015
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/1471-2253-15-15

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