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BMC Anesthesiology

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Open Access 01-12-2014 | Research article

The combination of MELD score and ICG liver testing predicts length of stay in the ICU and hospital mortality in liver transplant recipients

Authors: Stephanie Klinzing, Giovanna Brandi, Paul A Stehberger, Dimitri A Raptis, Markus Béchir

Published in: BMC Anesthesiology | Issue 1/2014

Abstract

Background

Early prediction of outcome would be useful for an optimal intensive care management of liver transplant recipients. Indocyanine green clearance can be measured non-invasively by pulse spectrophometry and is closely related to liver function.

Methods

This study was undertaken to assess the predictive value of a combination of the model of end stage liver disease (MELD) score and early indocyanine plasma disappearance rates (ICG-PDR) for length of stay in the intensive care unit (ICU), length of stay in the hospital and hospital mortality in liver transplant recipients.

Results

Fifty consecutive liver transplant recipients were included in this post Hoc single-center study. ICG-PDR was determined within 6 hours after ICU admission. Endpoints were length of stay in the ICU, length of hospital stay and hospital mortality. The combination of a high MELD score (MELD >25) and a low ICG-PDR clearance (ICG-PDR < 20%/minute) predicts a significant longer stay in the ICU (p = 0.004), a significant longer stay in the hospital (p < 0.001) and a hospital mortality of 40% vs. 0% (p = 0.003).

Conclusion

The combination of MELD scores and a singular ICG-PDR measurement in the early postoperative phase is an accurate predictor for outcome in liver transplant recipients. This easy-to-assess tool might be valuable for an optimal intensive care management of those patients.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2253/14/103/prepub

Title: The combination of MELD score and ICG liver testing predicts length of stay in the ICU and hospital mortality in liver transplant recipients
Authors: Stephanie Klinzing
Giovanna Brandi
Paul A Stehberger
Dimitri A Raptis
Markus Béchir
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Anesthesiology / Issue 1/2014
Electronic ISSN: 1471-2253
DOI: https://doi.org/10.1186/1471-2253-14-103

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The combination of MELD score and ICG liver testing predicts length of stay in the ICU and hospital mortality in liver transplant recipients

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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