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BMC Immunology
Published in: BMC Immunology 1/2014

Open Access 01-12-2014 | Review

MicroRNAs in hematopoietic development

Authors: Sara Montagner, Lorenzo Dehó, Silvia Monticelli

Published in: BMC Immunology | Issue 1/2014

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Abstract

Background

MicroRNAs (miRNAs) are short non-coding RNAs involved in the posttranscriptional regulation of a wide range of biological processes. By binding to complementary sequences on target messenger RNAs, they trigger translational repression and degradation of the target, eventually resulting in reduced protein output. MiRNA-dependent regulation of protein translation is a very widespread and evolutionarily conserved mechanism of posttranscriptional control of gene expression. Accordingly, a high proportion of mammalian genes are likely to be regulated by miRNAs. In the hematopoietic system, both transcriptional and posttranscriptional regulation of gene expression ensure proper differentiation and function of stem cells, committed progenitors as well as mature cells.

Results

In recent years, miRNA expression profiling of various cell types in the hematopoietic system, as well as gene-targeting approaches to assess the function of individual miRNAs, revealed the importance of this type of regulation in the development of both innate and acquired immunity.

Conclusions

We discuss the general role of miRNA biogenesis in the development of hematopoietic cells, as well as specific functions of individual miRNAs in stem cells as well as in mature immune cells.
Appendix
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Metadata
Title
MicroRNAs in hematopoietic development
Authors
Sara Montagner
Lorenzo Dehó
Silvia Monticelli
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Immunology / Issue 1/2014
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/1471-2172-15-14

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