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BMC Immunology

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Open Access 01-12-2013 | Research article

Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation

Authors: Halonna Kelly, Rajakumar Mandraju, Jordana GA Coelho-dos-Reis, Moriya Tsuji

Published in: BMC Immunology | Issue 1/2013

Abstract

Background

It has been shown that human immunodeficiency virus (HIV)-1 infection induces the production of endogenous lipids required for effective viral production, and the cluster of differentiation (CD)1 molecule CD1d is downregulated by HIV-1 infection. However, the role of endogenous lipid presentation and the implications of CD1 downregulation by HIV-1 infection have not yet been characterized.

Results

In this study, we observed downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced production of host cholesterol decreased the extent of CD1c and CD1d modulation. While the modest downregulation of CD1c by HIV-1 infection decreased the ability of CD1c-restricted T cells to respond and secrete interferon-γ, the cholesterol upregulation in the same cells by HIV-1 infection appears to limit the downregulation of CD1c.

Conclusions

The two conflicting HIV-1-mediated changes in CD1c expression appear to minimize the modulation of CD1c expression, thus leading the host to maintain a CD1c-restricted T-cell response against HIV-1.

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Title: Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation
Authors: Halonna Kelly
Rajakumar Mandraju
Jordana GA Coelho-dos-Reis
Moriya Tsuji
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Immunology / Issue 1/2013
Electronic ISSN: 1471-2172
DOI: https://doi.org/10.1186/1471-2172-14-4

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Conclusions

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