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BMC Immunology
Published in: BMC Immunology 1/2009

Open Access 01-12-2009 | Research article

The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells

Authors: Li-Chieh Wang, Yu-Li Lin, Yu-Chih Liang, Yao-Hsu Yang, Jyh-Hong Lee, Hsin-Hui Yu, Wen-Mein Wu, Bor-Luen Chiang

Published in: BMC Immunology | Issue 1/2009

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Abstract

Background

Propolis, an ancient herbal medicine, has been reported the beneficial effect both in asthma patients and murine model of asthma, but the mechanism was not clearly understood. In this study, the effect of caffeic acid phenethyl ester (CAPE), the most extensively studied components in propolis, on the functions of human monocyte-derived dendritic cells (MoDCs) was investigated.

Results

CAPE significantly inhibited IL-12 p40, IL-12 p70, IL-10 protein expression in mature healthy human MoDCs stimulated by lipopolysaccharides (LPS) and IL-12 p40, IL-10, IP-10 stimulated by crude mite extract. CAPE significantly inhibited IL-10 and IP-10 but not IL-12 expression in allergic patients' MoDCs stimulated by crude mite extract. In contrast, the upregulation of costimulatory molecules in mature MoDCs was not suppressed by CAPE. Further, the antigen presenting ability of DCs was not inhibited by CAPE. CAPE inhibited IκBα phosphorylation and NF-κB activation but not mitogen-activated protein kinase (MAPK) family phosphorylation in human MoDCs.

Conclusion

These results indicated that CAPE inhibited cytokine and chemokine production by MoDCs which might be related to the NF-κB signaling pathway. This study provided a new insight into the mechanism of CAPE in immune response and the rationale for propolis in the treatment of asthma and other allergic disorders.
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Metadata
Title
The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells
Authors
Li-Chieh Wang
Yu-Li Lin
Yu-Chih Liang
Yao-Hsu Yang
Jyh-Hong Lee
Hsin-Hui Yu
Wen-Mein Wu
Bor-Luen Chiang
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Immunology / Issue 1/2009
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/1471-2172-10-39

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