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Respiratory Research
Published in: Respiratory Research 1/2005

Open Access 01-12-2005 | Review

The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases

Authors: Tom Hsun-Wei Huang, Valentina Razmovski-Naumovski, Bhavani Prasad Kota, Diana Shu-Hsuan Lin, Basil D Roufogalis

Published in: Respiratory Research | Issue 1/2005

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Abstract

Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular disease and diabetes, attention has turned to lung diseases and whether knowledge of this receptor can be applied to therapy of the human airways. In this article, we explore the prospect of peroxisome proliferator-activated receptor-γ as a marker and treatment focal point of lung diseases such as asthma, chronic obstructive pulmonary disorder, lung cancer and cystic fibrosis. It is anticipated that peroxisome proliferator-activated receptor-γ ligands will provide not only useful mechanistic pathway information but also a possible new wave of therapies for sufferers of chronic respiratory diseases.
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Metadata
Title
The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases
Authors
Tom Hsun-Wei Huang
Valentina Razmovski-Naumovski
Bhavani Prasad Kota
Diana Shu-Hsuan Lin
Basil D Roufogalis
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2005
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-6-102

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