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Respiratory Research
Published in: Respiratory Research 1/2009

Open Access 01-12-2009 | Research

Asthma and genes encoding components of the vitamin D pathway

Authors: Yohan Bossé, Mathieu Lemire, Audrey H Poon, Denise Daley, Jian-Qing He, Andrew Sandford, John H White, Alan L James, William Arthur Musk, Lyle J Palmer, Benjamin A Raby, Scott T Weiss, Anita L Kozyrskyj, Allan Becker, Thomas J Hudson, Catherine Laprise

Published in: Respiratory Research | Issue 1/2009

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Abstract

Background

Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy.

Methods

Eleven candidate genes were chosen for this study, five of which code for proteins in the vitamin D metabolism pathway (CYP27A1, CYP27B1, CYP2R1, CYP24A1, GC) and six that are known to be transcriptionally regulated by vitamin D (IL10, IL1RL1, CD28, CD86, IL8, SKIIP). For each gene, we selected a maximally informative set of common SNPs (tagSNPs) using the European-derived (CEU) HapMap dataset. A total of 87 SNPs were genotyped in a French-Canadian family sample ascertained through asthmatic probands (388 nuclear families, 1064 individuals) and evaluated using the Family Based Association Test (FBAT) program. We then sought to replicate the positive findings in four independent samples: two from Western Canada, one from Australia and one from the USA (CAMP).

Results

A number of SNPs in the IL10, CYP24A1, CYP2R1, IL1RL1 and CD86 genes were modestly associated with asthma and atopy (p < 0.05). Two-gene models testing for both main effects and the interaction were then performed using conditional logistic regression. Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002). In the replicate samples, SNPs in the IL10 and CYP24A1 genes were again modestly associated with asthma and atopy (p < 0.05). However, the SNPs or the orientation of the risk alleles were different between populations. A two-gene model involving IL10 and VDR was replicated in CAMP, but not in the other populations.

Conclusion

A number of genes involved in the vitamin D pathway demonstrate modest levels of association with asthma and atopy. Multilocus models testing genes in the same pathway are potentially more effective to evaluate the risk of asthma, but the effects are not uniform across populations.
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Literature
1.
National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma Update on Selected Topics--2002 J Allergy Clin Immunol 2002,110(5 Suppl):S141–219.
2.
3.
Bosse Y, Hudson TJ: Toward a comprehensive set of asthma susceptibility genes. Annu Rev Med 2007, 58:171–184.CrossRefPubMed
4.
Ober C, Hoffjan S: Asthma genetics the long and winding road to gene discovery. Genes Immun 2006,7(2):95–100.CrossRefPubMed
5.
6.
Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO: Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007,448(7152):470–473.CrossRefPubMed
7.
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr, Nicolae DL, Elias JA, Chupp GL: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. The New England journal of medicine 2008,358(16):1682–1691.CrossRefPubMedPubMedCentral
8.
Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Kramer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, et al.: Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet 2008,4(8):e1000166.CrossRefPubMedPubMedCentral
9.
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006,311(5768):1770–1773.CrossRefPubMed
10.
Cantorna MT, Zhu Y, Froicu M, Wittke A: Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004,80(6 Suppl):1717S-1720S.PubMed
11.
Hayes CE, Nashold FE, Spach KM, Pedersen LB: The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 2003,49(2):277–300.
12.
13.
14.
Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH: Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 2005,19(11):2685–2695.CrossRefPubMed
15.
Hewison M, Freeman L, Hughes SV, Evans KN, Bland R, Eliopoulos AG, Kilby MD, Moss PA, Chakraverty R: Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol 2003,170(11):5382–5390.CrossRefPubMed
16.
Veldman CM, Cantorna MT, DeLuca HF: Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000,374(2):334–338.CrossRefPubMed
17.
D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P: Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998,101(1):252–262.CrossRefPubMedPubMedCentral
18.
Overbergh L, Decallonne B, Waer M, Rutgeerts O, Valckx D, Casteels KM, Laureys J, Bouillon R, Mathieu C: 1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524–543). Diabetes 2000,49(8):1301–1307.CrossRefPubMed
19.
Wittke A, Weaver V, Mahon BD, August A, Cantorna MT: Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 2004,173(5):3432–3436.CrossRefPubMed
20.
van Etten E, Verlinden L, Giulietti A, Ramos-Lopez E, Branisteanu DD, Ferreira GB, Overbergh L, Verstuyf A, Bouillon R, Roep BO, Badenhoop K, Mathieu C: The vitamin D receptor gene FokI polymorphism: functional impact on the immune system. Eur J Immunol 2007,37(2):395–405.CrossRefPubMed
21.
Poon AH, Laprise C, Lemire M, Montpetit A, Sinnett D, Schurr E, Hudson TJ: Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med 2004,170(9):967–973.CrossRefPubMed
22.
Raby BA, Lazarus R, Silverman EK, Lake S, Lange C, Wjst M, Weiss ST: Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 2004,170(10):1057–1065.CrossRefPubMed
23.
Millstein J, Conti DV, Gilliland FD, Gauderman WJ: A testing framework for identifying susceptibility genes in the presence of epistasis. Am J Hum Genet 2006,78(1):15–27.CrossRefPubMed
24.
Schaid DJ, McDonnell SK, Hebbring SJ, Cunningham JM, Thibodeau SN: Nonparametric tests of association of multiple genes with human disease. Am J Hum Genet 2005,76(5):780–793.CrossRefPubMedPubMedCentral
25.
Skin tests used in type I allergy testing Position paper. Sub-Committee on Skin Tests of the European Academy of Allergology and Clinical Immunology Allergy 1989,44(Suppl 10):1–59.
26.
Begin P, Tremblay K, Daley D, Lemire M, Claveau S, Salesse C, Kacel S, Montpetit A, Becker A, Chan-Yeung M, Kozyrskyj AL, Hudson TJ, Laprise C: Association of urokinase-type plasminogen activator with asthma and atopy. Am J Respir Crit Care Med 2007,175(11):1109–1116.CrossRefPubMed
27.
Chan-Yeung M, Manfreda J, Dimich-Ward H, Ferguson A, Watson W, Becker A: A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med 2000,154(7):657–663.CrossRefPubMed
28.
Chan-Yeung M, Ferguson A, Watson W, Dimich-Ward H, Rousseau R, Lilley M, Dybuncio A, Becker A: The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol 2005,116(1):49–55.CrossRefPubMed
29.
The Childhood Asthma Management Program (CAMP) design, rationale, and methods. Childhood Asthma Management Program Research Group Control Clin Trials 1999,20(1):91–120.
30.
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group The New England journal of medicine 2000,343(15):1054–1063.
31.
32.
Prosser DE, Jones G: Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 2004,29(12):664–673.CrossRefPubMed
33.
MacDonald PN, Dowd DR, Zhang C, Gu C: Emerging insights into the coactivator role of NCoA62/SKIP in Vitamin D-mediated transcription. J Steroid Biochem Mol Biol 2004,89–90(1–5):179–186.CrossRefPubMed
34.
A haplotype map of the human genome Nature 2005,437(7063):1299–1320.
35.
Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA: Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004,74(1):106–120.CrossRefPubMed
36.
Bell PA, Chaturvedi S, Gelfand CA, Huang CY, Kochersperger M, Kopla R, Modica F, Pohl M, Varde S, Zhao R, Zhao X, Boyce-Jacino MT, Yassen A: SNPstream UHT: ultra-high throughput SNP genotyping for pharmacogenomics and drug discovery. Biotechniques 2002, (Suppl):70–77. 74, 76–77
37.
38.
Oliphant A, Barker DL, Stuelpnagel JR, Chee MS: BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques 2002, (Suppl):56–61. 60–61
39.
Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST: IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol 2004,26(2):155–165.CrossRefPubMedPubMedCentral
40.
Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM: Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004,26(1):61–69.CrossRefPubMed
41.
Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005,21(2):263–265.CrossRefPubMed
42.
Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Pare PD, Hudson TJ: Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet 2009,125(4):445–459.CrossRefPubMed
43.
Cordell HJ, Barratt BJ, Clayton DG: Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol 2004,26(3):167–185.CrossRefPubMed
44.
Dudbridge F: Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008,66(2):87–98.CrossRefPubMedPubMedCentral
45.
Shin HD, Winkler C, Stephens JC, Bream J, Young H, Goedert JJ, O'Brien TR, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien SJ, Smith MW: Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proc Natl Acad Sci USA 2000,97(26):14467–14472.CrossRefPubMedPubMedCentral
46.
Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P: Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999,42(6):1101–1108.CrossRefPubMed
47.
Rosenwasser LJ, Borish L: Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med 1997,156(4 Pt 2):S152–155.CrossRefPubMed
48.
Hajeer AH, Lazarus M, Turner D, Mageed RA, Vencovsky J, Sinnott P, Hutchinson IV, Ollier WE: IL-10 gene promoter polymorphisms in rheumatoid arthritis. Scand J Rheumatol 1998,27(2):142–145.CrossRefPubMed
49.
Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV: An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997,24(1):1–8.CrossRefPubMed
50.
Zhang J, Chen H, Hu L, Fu J, Zhang H, Chen Y: [Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression]. Zhonghua Yi Xue Za Zhi 2002,82(2):114–118.PubMed
51.
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001, 19:683–765.CrossRefPubMed
52.
Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L: Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 1998,158(6):1958–1962.CrossRefPubMed
53.
Lim S, Crawley E, Woo P, Barnes PJ: Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998,352(9122):113.CrossRefPubMed
54.
Karjalainen J, Hulkkonen J, Nieminen MM, Huhtala H, Aromaa A, Klaukka T, Hurme M: Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma. Clin Exp Allergy 2003,33(1):78–83.CrossRefPubMed
55.
Wjst M, Altmuller J, Faus-Kessler T, Braig C, Bahnweg M, Andre E: Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res 2006, 7:60.CrossRefPubMedPubMedCentral
56.
Burgess JL, Fierro MA, Lantz RC, Hysong TA, Fleming JE, Gerkin R, Hnizdo E, Conley SM, Klimecki W: Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters. J Occup Environ Med 2004,46(10):1013–1022.CrossRefPubMed
57.
Van Neerven RJ, Pol MM, Zee JS, Stiekema FE, De Boer M, Kapsenberg ML: Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression. Clin Exp Allergy 1998,28(7):808–816.CrossRefPubMed
58.
Heinzmann A, Plesnar C, Kuehr J, Forster J, Deichmann KA: Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy. Eur J Immunogenet 2000,27(2):57–61.CrossRefPubMed
59.
Howard TD, Postma DS, Hawkins GA, Koppelman GH, Zheng SL, Wysong AK, Xu J, Meyers DA, Bleecker ER: Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. J Allergy Clin Immunol 2002,110(5):743–751.CrossRefPubMed
60.
Nakao F, Ihara K, Ahmed S, Sasaki Y, Kusuhara K, Takabayashi A, Nishima S, Hara T: Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. Exp Clin Immunogenet 2000,17(4):179–184.CrossRefPubMed
61.
Lohning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A, Kamradt T: T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA 1998,95(12):6930–6935.CrossRefPubMedPubMedCentral
62.
Trajkovic V, Sweet MJ, Xu D: T1/ST2--an IL-1 receptor-like modulator of immune responses. Cytokine Growth Factor Rev 2004,15(2–3):87–95.CrossRefPubMed
63.
Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005,23(5):479–490.CrossRefPubMed
64.
Shimizu M, Matsuda A, Yanagisawa K, Hirota T, Akahoshi M, Inomata N, Ebe K, Tanaka K, Sugiura H, Nakashima K, Tamari M, Takahashi N, Obara K, Enomoto T, Okayama Y, Gao PS, Huang SK, Tominaga S, Ikezawa Z, Shirakawa T: Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet 2005,14(19):2919–2927.CrossRefPubMed
65.
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009,41(3):342–347.CrossRefPubMed
66.
Laufs J, Andrason H, Sigvaldason A, Halapi E, Thorsteinsson L, Jonasson K, Soebech E, Gislason T, Gulcher JR, Stefansson K, Hakonarson H: Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. Am J Pharmacogenomics 2004,4(1):63–68.CrossRefPubMed
67.
Heinzmann A, Ahlert I, Kurz T, Berner R, Deichmann KA: Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 2004,114(3):671–676.CrossRefPubMed
68.
Pastinen T, Ge B, Gurd S, Gaudin T, Dore C, Lemire M, Lepage P, Harmsen E, Hudson TJ: Mapping common regulatory variants to human haplotypes. Hum Mol Genet 2005,14(24):3963–3971.CrossRefPubMed
69.
Bosse Y, Maghni K, Hudson TJ: 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol Genomics 2007,29(2):161–168.CrossRefPubMed
70.
Zhang X, Li P, Bao J, Nicosia SV, Wang H, Enkemann SA, Bai W: Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. J Biol Chem 2005,280(42):35458–35468.CrossRefPubMedPubMedCentral
71.
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D: The structure of haplotype blocks in the human genome. Science 2002,296(5576):2225–2229.CrossRefPubMed
Metadata
Title
Asthma and genes encoding components of the vitamin D pathway
Authors
Yohan Bossé
Mathieu Lemire
Audrey H Poon
Denise Daley
Jian-Qing He
Andrew Sandford
John H White
Alan L James
William Arthur Musk
Lyle J Palmer
Benjamin A Raby
Scott T Weiss
Anita L Kozyrskyj
Allan Becker
Thomas J Hudson
Catherine Laprise
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2009
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-10-98

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