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Respiratory Research
Published in: Respiratory Research 1/2009

Open Access 01-12-2009 | Review

Role of ADAM and ADAMTS metalloproteinases in airway diseases

Authors: Genevieve Paulissen, Natacha Rocks, Maud M Gueders, Celine Crahay, Florence Quesada-Calvo, Sandrine Bekaert, Jonathan Hacha, Mehdi El Hour, Jean-Michel Foidart, Agnes Noel, Didier D Cataldo

Published in: Respiratory Research | Issue 1/2009

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Abstract

Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD.
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Metadata
Title
Role of ADAM and ADAMTS metalloproteinases in airway diseases
Authors
Genevieve Paulissen
Natacha Rocks
Maud M Gueders
Celine Crahay
Florence Quesada-Calvo
Sandrine Bekaert
Jonathan Hacha
Mehdi El Hour
Jean-Michel Foidart
Agnes Noel
Didier D Cataldo
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2009
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-10-127

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Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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