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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2014

Open Access 01-12-2014 | Meeting abstract

EHMTI-0092. Activation of the 5-HT2B receptor induces dural plasma protein extravasation in a mouse migraine model

Authors: A Hunfeld, M Kremser, D Segelcke, H Lübbert

Published in: The Journal of Headache and Pain | Special Issue 1/2014

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Excerpt

Migraine attacks originate in the meninges which are densely innervated by trigeminal nerve fibers. Upon stimulation, endothelial cells of dural blood vessels secrete nitric oxide and as a consequence, neuropeptides are released from trigeminal nerve fibers. This, in turn, leads to meningeal plasmaproteinextravasation (PPE) and vasodilation. Inflammatory components such as PPE and vasodilation serve as indicators for migraine attacks in animal models. A guinea pig migraine model was described in which the partial 5-HT2B/2C receptor agonist meta-Chlorphenylpiperazine (mCPP) is applied to induce PPE in the dura mater. We have transferred this model to mice. …
Metadata
Title
EHMTI-0092. Activation of the 5-HT2B receptor induces dural plasma protein extravasation in a mouse migraine model
Authors
A Hunfeld
M Kremser
D Segelcke
H Lübbert
Publication date
01-12-2014
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2014
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-15-S1-F11

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