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Open Access 01-12-2013 | Consensus article

Neuromodulation of chronic headaches: position statement from the European Headache Federation

Authors: Paolo Martelletti, Rigmor H Jensen, Andrea Antal, Roberto Arcioni, Filippo Brighina, Marina de Tommaso, Angelo Franzini, Denys Fontaine, Max Heiland, Tim P Jürgens, Massimo Leone, Delphine Magis, Koen Paemeleire, Stefano Palmisani, Walter Paulus, Arne May

Published in: The Journal of Headache and Pain | Issue 1/2013

Abstract

The medical treatment of patients with chronic primary headache syndromes (chronic migraine, chronic tension-type headache, chronic cluster headache, hemicrania continua) is challenging as serious side effects frequently complicate the course of medical treatment and some patients may be even medically intractable. When a definitive lack of responsiveness to conservative treatments is ascertained and medication overuse headache is excluded, neuromodulation options can be considered in selected cases.

Here, the various invasive and non-invasive approaches, such as hypothalamic deep brain stimulation, occipital nerve stimulation, stimulation of sphenopalatine ganglion, cervical spinal cord stimulation, vagus nerve stimulation, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, and transcutaneous electrical nerve stimulation are extensively published although proper RCT-based evidence is limited. The European Headache Federation herewith provides a consensus statement on the clinical use of neuromodulation in headache, based on theoretical background, clinical data, and side effect of each method. This international consensus further gives recommendations for future studies on these new approaches.

In spite of a growing field of stimulation devices in headaches treatment, further controlled studies to validate, strengthen and disseminate the use of neurostimulation are clearly warranted. Consequently, until these data are available any neurostimulation device should only be used in patients with medically intractable syndromes from tertiary headache centers either as part of a valid study or have shown to be effective in such controlled studies with an acceptable side effect profile.

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, et al.: Years lived with disability (YLD) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380: 2163–2196.PubMed

Steiner TJ, Stovner LJ, Birbeck GL: Migraine: the seventh disabler. Headache Pain 2013, 14: 1.

May A, Leone M, Afra J, Linde M, Sándor PS, Evers S, Goadsby PJ, Task Force EFNS: EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol 2006, 13: 1066–77.PubMed

Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sándor PS, European Federation of Neurological Societies: EFNS guideline on the drug treatment of migraine--revised report of an EFNS task force. Eur J Neurol 2009, 16: 968–981. doi: 10.1111/j.1468–1331.2009.02748.xPubMed

Steiner TJ, Antonaci F, Jensen R, Lainez MJ, Lanteri-Minet M, Valade D, European Headache Federation, Global Campaign against Headache: Recommendations for headache service organisation and delivery in Europe. J Headache and Pain 2011, 12: 419–426. doi: 10.1007/s10194–011–0320-x

Lionetto L, Negro A, Palmisani S, Gentile G, Del Fiore MR, Mercieri M, Simmaco M, Smith T, Al-Kaisy A, Arcioni R, Martelletti P: Emerging treatment for chronic migraine and refractory chronic migraine. Expert Opin Emerg Drugs 2012, 17: 393–406.PubMed

Negro A, Martelletti P: Chronic migraine plus medication overuse headache: two entities or not? J Headache Pain 2011, 12: 593–601.PubMedCentralPubMed

Schulman EA, Peterlin BL, Lake AE 3rd, Lipton RB, Hanlon A, Siegel S, Levin M, Goadsby PJ, Markley HG: Defining Refractory Migraine: results of the RHSIS Survey of American Headache Society Members. Headache 2009, 49: 509–518.PubMed

May A: Cluster headache: pathogenesis, diagnosis, and management. Lancet 2005, 366: 843–55.PubMed

10.

Goadsby PJ, Schoenen J, Ferrari MD, Silberstein SD, Dodick D: Towards a definition of intractable headache for use in clinical practice and trials. Cephalalgia 2006, 26: 1168–70.PubMed

11.

Matharu MS, Goadsby PJ: Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 2002, 125: 976–984.PubMed

12.

Black D, Dodick DW: Two cases of medically and surgically intractable SUNCT: a reason for caution and argument for a central mechanism. Cephalalgia 2002, 3: 201–204.

13.

Jarrar RG, Black DF, Dodick DW, Davis DH: Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 2003, 60: 1360–1362.PubMed

14.

Donnet A, Valade D, Regis J: Gamma knife treatment for refractory cluster headache: a prospective open trial. J Neurol Neurosurg Psychiatry 2005, 76: 218–221.PubMedCentralPubMed

15.

Schoenen J, Jensen RH, Lantéri-Minet M, Láinez MJ, Gaul C, Goodman AM, et al.: Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. Cephalalgia 2013. doi: 10.1177/0333102412473667

16.

Pedersen JL, Barloese M, Jensen RH: Neurostimulation in cluster headache: A review of current progress. Cephalalgia 2013. [Epub ahead of print] doi: 10.1177/0333102413489040

17.

Leone M, May A, Franzini A, Broggi G, Dodick D, Rapoport A, Goadsby PJ, Schoenen J, Bonavita V, Bussone G: Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection. Cephalalgia 2004, 24: 934–7.PubMed

18.

May A, Bahra A, Büchel C, Frackowiak RSJ, Goadsby PJ: Hypothalamic activation in cluster headache attacks. Lancet 1998, 352: 275–78.PubMed

19.

May A, Ashburner J, Buchel C, et al.: Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999, 5: 836–38.PubMed

20.

Leone M, Franzini A, Bussone G: Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med 2001, 345: 1428–29.PubMed

21.

Schoenen J, Di Clemente L, Vandenheede M, et al.: Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 2005, 128: 940–47.PubMed

22.

Leone M, Franzini A, Broggi G, Bussone G: Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology 2006, 67: 150–52.PubMed

23.

D’Andrea G, Nordera G, Piacentino M: Effectiveness of hypothalamic stimulation in two patients affected by intractable chronic cluster headache. Neurology 2006,66(suppl 2):A140. abstr

24.

Benabid A, Seigneuret E, Torres N: Intraventricular stimulation for targets close to the midline: periaqueductal gray, posterior hypothalamus, anterior hypothalamus, subcommissural structures. Acta Neurochir 2006, 148: 1–64. abstr

25.

Starr PA, Barbaro NM, Raskin NH, Ostrem JL: Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg 2007, 106: 999–1005.PubMed

26.

Owen SL, Green AL, Davies P, et al.: Connectivity of an effective hypothalamic surgical target for cluster headache. J Clin Neurosci 2007,14(10):955–60.PubMed

27.

Black D, Bartleson J, Torgrimson S, Davis D: Two cases of chronic cluster headache treated successfully with hypothalamic deep brain stimulation. Neurology (abstract) 2007,68(1):A307.

28.

Mateos V, Seijo F, Lozano B, et al.: Deep brain stimulation in chronic refractory headaches: first national cases. Neurologia (abstract) 2007, 22: 96.

29.

Bartsch T, Pinsker MO, Rasche D, et al.: Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia 2008, 28: 285–95.PubMed

30.

Fontaine D, Lazorthes Y, Mertens P, et al.: Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain 2010, 11: 23–31.PubMedCentralPubMed

31.

Hidding U, May A: Mere surgery will not cure cluster headache: implications for neurostimulation. Cephalalgia 2011, 31: 112–15.PubMed

32.

Seijo F, Saiz A, Lozano B, et al.: Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: experience in five patients with a modified anatomical target. Cephalalgia 2011, 31: 1634–41.PubMed

33.

Leone M, Franzini A, Proietti Cecchini A, Bussone G: Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache. Pain 2013, 154: 89–94.PubMed

34.

Leone M, Franzini A, D’Andrea G, Broggi G, Casucci G, Bussone G: Deep brain stimulation to relieve drug-resistant SUNCT. Ann Neurol 2005, 57: 924–27.PubMed

35.

Lyons MK, Dodick DW, Evidente VG: Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg 2009, 110: 279–81.PubMed

36.

Bartsch T, Falk D, Knudsen K, et al.: Deep brain stimulation of the posterior hypothalamic area in intractable short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Cephalalgia 2011, 31: 1405–08.PubMed

37.

Walcott BP, Bamber NI, Anderson DE: Successful treatment of chronic paroxysmal hemicrania with posterior hypothalamic stimulation: technical case report. Neurosurgery 2009, 65: E997.PubMed

38.

Headache classification subcommittee of the International Headache Society: The International Classification of Headache Disorders, 2nd edn. Cephalalgia 2004,24(suppl 1):9–160.

39.

Leone M, Franzini A, Broggi G, Mea E, Cecchini AP, Bussone G: Acute hypothalamic stimulation and ongoing cluster headache attacks. Neurology 2006, 67: 1844–45.PubMed

40.

The deep-brain stimulation for Parkinson’s disease group: Deep-brain stimulation on the subthalamic nucleus or pars interna of the globus pallidus in Parkinson’s disease. N Engl J Med 2001, 345: 956–96335.

41.

Fontaine D, Lanteri-Minet M, Ouchchane L, et al.: Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache. Brain 2010, 133: 1214–23.PubMed

42.

Maniyar FH, Starr P, Goadsby PJ: Paroxysmal sneezing after hypothalamic deep brain stimulation for cluster headache. Cephalalgia 2012,32(8):641–644.PubMed

43.

Cortelli P, Guaraldi P, Leone M, et al.: Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients. Eur J Neurol 2007, 14: 1008–1536.PubMed

44.

Vetrugno R, Pierangeli G, Leone M, et al.: Effect on sleep of posterior hypothalamus stimulation in cluster headache. Headache 2007, 47: 1085–90.PubMed

45.

Jürgens T, Leone M, Proietti-Cecchini A, et al.: Hypothalamic deep-brain stimulation modulates thermal sensitivity and pain thresholds in cluster headache. Pain 2009, 146: 84–90.PubMed

46.

May A, Leone M, Boecker H, et al.: Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci 2006, 26: 3589–93.PubMed

47.

May A: Chronic pain may change the structure of the brain. Pain 2008, 137: 7–15.PubMed

48.

Zhuo M: Cortical excitation and chronic pain. Trends Neurosci 2008, 31: 199–207.PubMed

49.

Bartsch T, Goadsby PJ: Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input. Brain 2002, 125: 1496–509.PubMed

50.

Bartsch T, Goadsby PJ: Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Brain 2003, 126: 1801–13.PubMed

51.

Anthony M: Headache and the greater occipital nerve. Clinical neurology and neurosurgery 1992, 94: 297–301.PubMed

52.

Ambrosini A, Vandenheede M, Rossi P, Aloj F, Sauli E, Pierelli F, et al.: Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain 2005, 118: 92–6.PubMed

53.

Afridi SK, Shields KG, Bhola R, Goadsby PJ: Greater occipital nerve injection in primary headache syndromes–prolonged effects from a single injection. Pain 2006, 122: 126–9.PubMed

54.

Weiner RL, Reed KL: Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation 1999, 2: 217–22.PubMed

55.

Lipton R, Goadsby P, Cady R, Aurora SK, Grosberg B, Freitag F, et al.: PRISM study: occipital nerve stimulation for treatment-refractory migraine. Cephalalgia 2009, 29: 30.

56.

Saper JR, Dodick DW, Silberstein SD, McCarville S, Sun M, Goadsby PJ: Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study. Cephalalgia 2011, 31: 271–85.PubMedCentralPubMed

57.

Silberstein S, Dodick D, Saper J, Huh B, Slavin KV, Sharan A, et al.: Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: Results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia 2012,32(16):1165–79.PubMed

58.

Magis D, Schoenen J: Advances and challenges in neurostimulation for headaches. Lancet Neurol 2012, 11: 708–19.PubMed

59.

Reed KL, Black SB, Banta CJ 2nd, Will KR: Combined occipital and supraorbital neurostimulation for the treatment of chronic migraine headaches: initial experience. Cephalalgia 2010, 30: 260–71.PubMed

60.

Burns B, Watkins L, Goadsby PJ: Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology 2009, 72: 341–5.PubMed

61.

Magis D, Gerardy PY, Remacle JM, Schoenen J: Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. Headache 2011, 51: 1191–201.PubMed

62.

Magis D, Allena M, Bolla M, De Pasqua V, Remacle JM, Schoenen J: Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol 2007, 6: 314–21.PubMed

63.

Fontaine D, Christophe Sol J, Raoul S, Fabre N, Geraud G, Magne C, et al.: Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation. Cephalalgia 2011, 31: 1101–5.PubMed

64.

Burns B, Watkins L, Goadsby PJ: Treatment of hemicrania continua by occipital nerve stimulation with a bion device: long-term follow-up of a crossover study. Lancet Neurol 2008, 7: 1001–12.PubMed

65.

Marin JC, Goadsby P: Response of SUNCT (Short-Lasting Unilateral Neuralgiform Headaches with Conjunctival Injection and Tearing), SUNA (Short-LAsting Unilateral Neuralgifom Headaches with Autonomic Symptoms) and Primary Stabbing Headaches to Occipital Nerve Stimulation (ONS). Neurology 2010, 74: P04.006. abstract

66.

Shanahan P, Watkins L, Matharu M: Treatment of medically intractable short- lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with autonomic symptoms (SUNA) with occipital nerve stimulation (ONS) in 6 patients. Cephalalgia 2009, 29: 150.

67.

Magis D, Bruno MA, Fumal A, Gerardy PY, Hustinx R, Laureys S, et al.: Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. BMC Neurol 2011, 11: 25.PubMedCentralPubMed

68.

Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ: Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 2004, 127: 220–30.PubMed

69.

Natsis K, Baraliakos X, Appell HJ, Tsikaras P, Gigis I, Koebke J: The course of the greater occipital nerve in the suboccipital region: a proposal for setting landmarks for local anesthesia in patients with occipital neuralgia. Clinical anatomy 2006, 19: 332–6.PubMed

70.

Paemeleire K, Van Buyten JP, Van Buynder M, Alicino D, Van Maele G, Smet I, et al.: Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. Cephalalgia 2010, 30: 662–73.PubMed

71.

May A: Headaches with (ipsilateral) autonomic symptoms. J Neurol 2003, 250: 1273–8.PubMed

72.

Devoghel JC: Cluster headache and sphenopalatine block. Acta Anaesthesiol Belg 1981, 32: 101–7.PubMed

73.

Felisati G, Arnone F, Lozza P, Leone M, Curone M, Bussone G: Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. Laryngoscope 2006, 116: 1447–50.PubMed

74.

Narouze S, Kapural L, Casanova J, Mekhail N: Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache 2009, 49: 571–7.PubMed

75.

Ruskell GL: Orbital passage of pterygopalatine ganglion efferents to paranasal sinuses and nasal mucosa in man. Cells Tissues Organs 2003, 175: 223–28.PubMed

76.

Oomen KP, Van Wijck AJ, Hordijk GJ, De Ru JA: Effects of radiofrequency thermocoagulation of the sphenopalatine ganglion on headache and facial pain: correlation with diagnosis. J Orofac Pain 2012, 26: 59–64.PubMed

77.

Narouze SN: Role of sphenopalatine ganglion neuroablation in the management of cluster headache. Curr Pain Headache Rep 2010, 14: 160–3.PubMed

78.

Sanders M, Zuurmond WW: Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: a 12- to 70-month follow-up evaluation. J Neurosurg 1997, 87: 876–80.PubMed

79.

Blumenfeld A, Ashkenazi A, Napchan U, Bender SD, Klein BC, Berliner R, et al.: Expert Consensus Recommendations for the Performance of Peripheral Nerve Blocks for Headaches - A Narrative Review. Headache 2013, 53: 437–46.PubMed

80.

Ansarinia M, Rezai A, Tepper SJ, Steiner CP, Stump J, Stanton-Hicks M, et al.: Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches. Headache 2010, 50: 1164–74.PubMed

81.

Tepper SJ, Rezai A, Narouze S, Steiner C, Mohajer P, Ansarinia M: Acute treatment of intractable migraine with sphenopalatine ganglion electrical stimulation. Headache 2009, 49: 983–9.PubMed

82.

Schytz HW, Barløse M, Guo S, Selb J, Caparso A, Jensen R, et al.: Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans. Cephalalgia 2013.

83.

Ammons WS, Blair RW, Foreman RD: Vagal afferent inhibition of primate thoracic spinothalamic neurons. J Neurophysiol 1983, 50: 926–940.PubMed

84.

Thies R, Foreman RD: Inhibition and excitation of thoracic spinoreticular neurons by electrical stimulation of vagal afferent nerves. Exp Neurol 1983, 82: 1–16.PubMed

85.

Maixner W, Randich A: Role of the right vagal nerve trunk in antinociception. Brain Res 1984, 298: 374–377.PubMed

86.

Ren K, Randich A, Gebhart GF: Vagal afferent modulation of spinal nociceptive transmission in the rat. J Neurophysiol 1989, 62: 401–415.PubMed

87.

Randich A, Ren K, Gebhart GF: Electrical stimulation of cervical vagal afferents. II. Central relays for behavioral antinociception and arterial blood pressure decreases. J Neurophysiol 1990, 64: 1115–1124.PubMed

88.

Chandler MJ, Hobbs SF, Bolser DC, Foreman RD: Effects of vagal afferent stimulation on cervical spinothalamic tract neurons in monkeys. Pain 1991, 44: 81–87.PubMed

89.

Aicher SA, Lewis SJ, Randich A: Antinociception produced by electrical stimulation of vagal afferents: independence of cervical and subdiaphragmatic branches. Brain Res 1991, 542: 63–70.PubMed

90.

Thurston CL, Randich A: Quantitative characterization and spinal substrates of antinociception produced by electrical stimulation of the subdiaphragmatic vagus in rats. Pain 1991, 44: 201–209.PubMed

91.

Thurston CL, Randich A: Effects of vagal afferent stimulation on ON and OFF cells in the rostroventral medulla: Relationships to nociception and arterial blood pressure. J Neurophysiol 1992, 67: 180–196.PubMed

92.

Rutecki P: Anatomical, physiological, and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 1990,31(Suppl 2):S1–6.PubMed

93.

Bossut DF, Maixner W: Effects of cardiac vagal afferent electrostimulation on the response of trigeminal and trigeminothalamic neurons to noxious orofacial stimulation. Pain 1996, 65: 101–109.PubMed

94.

Evans AR, Jones SL, Blair RW: Effects of vagal afferent nerve stimulation on noxious heat-evoked Fos-like immunoreactivity in the rat lumbar spinal cord. J Comp Neurol 1994, 22: 490–498.

95.

Nishikawa Y, Koyama N, Yoshida Y, Yokota T: Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis. Brain Res 1999, 833: 108–111.PubMed

96.

Hord ED, Evans MS, Mueed S, Adamolekun B, Naritoku DK: The effect of vagus nerve stimulation on migraines. J Pain 2003, 4: 530–534.PubMed

97.

Lenaerts ME, Oommen KJ, Couch JR, Skaggs V: Can vagus nerve stimulation help migraine? Cephalalgia 2008, 28: 392–395.PubMed

98.

Mauskop A: Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia 2005, 25: 82–86.PubMed

99.

Ventureyra EC: Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept. Childs Nerv Syst 2000, 16: 101–102.PubMed

100.

Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P, Reiners K, Riederer P: Far field potentials from the brain stem after transcutaneous vagus nerve stimulation. J Neural Transm 2003,110(12):1437–1443.PubMed

101.

Fallgatter AJ, Ehlis AC, Ringel TM, Herrmann MJ: Age effect on far field potentials from the brain stem after transcutaneous vagus nerve stimulation. Int J Psychophysiol 2005,56(1):37–43.PubMed

102.

Nesbitt AD, Marin JCA, Tomkins E, Ruttledge MH, Goadsby PJ: Non-invasive vagus nerve stimulation for the treatment of cluster headache: a case series. J Headache Pain 2013,1(Suppl 1):P231.

103.

Magis D, Gérard P, Schoenen J: Transcutaneous Vagus Nerve Stimulation (tVNS) for headache prophylaxis: initial experience. J Headache Pain 2013,1(Suppl 1):P198.

104.

Nitsche MA, Paulus W: Transcranial direct current stimulation update 2011. Restor Neurol Neurosci 2011, 29: 463–492.PubMed

105.

Antal A, Paulus W, Nitsche MA: Electrical stimulation and visual network plasticity. Restor Neurol Neurosci 2011, 29: 365–374.PubMed

106.

Bindman LJ, Lippold OC, Redfearn JW: The Action of Brief Polarizing Currents on the Cerebral Cortex of the Rat (1) during Current Flow and (2) in the Production of Long-Lasting after-Effects. J Physiol 1964, 172: 369–382.PubMedCentralPubMed

107.

Bohotin V, Fumal A, Vandenheede M, Gerard P, Bohotin C, Maertens de Noordhout A, Schoenen J: Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 2002, 125: 912–922.PubMed

108.

Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F: A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol 2011, 14: 1133–1145.PubMed

109.

Creutzfeldt OD, Fromm GH, Kapp H: Influence of transcortical d-c currents on cortical neuronal activity. Exp Neurol 1962, 5: 436–452.PubMed

110.

Nitsche MA, Paulus W: Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000,527(Pt 3):633–639.PubMedCentralPubMed

111.

Nitsche MA, Paulus W: Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 2001, 57: 1899–1901.PubMed

112.

Liebetanz D, Nitsche MA, Tergau F, Paulus W: Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain 2002, 125: 2238–2247.PubMed

113.

Antal A, Paulus W: A case of refractory orofacial pain treated by transcranial direct current stimulation applied over hand motor area in combination with NMDA agonist drug intake. Brain Stimul 2011, 4: 117–121.PubMed

114.

Antal A, Kriener N, Lang N, Boros K, Paulus W: Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine. Cephalalgia 2011, 31: 820–828.PubMed

115.

Auvichayapat P, Janyacharoen T, Rotenberg A, Tiamkao S, Krisanaprakornkit T, Sinawat S, Punjaruk W, Thinkhamrop B, Auvichayapat N: Migraine prophylaxis by anodal transcranial direct current stimulation, a randomized, placebo-controlled trial. J Med Assoc Thai 2012, 95: 1003–1012.PubMed

116.

Dasilva AF, Mendonca ME, Zaghi S, Lopes M, Dossantos MF, Spierings EL, Bajwa Z, Datta A, Bikson M, Fregni F: tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache 2012, 52: 1283–1295.PubMedCentralPubMed

117.

Priori A, Hallett M, Rothwell JC: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation? Brain Stimul 2009, 2: 241–245.PubMed

118.

Poreisz C, Boros K, Antal A, Paulus W: Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain Res Bull 2007, 72: 208–214.PubMed

119.

Ambrus GG, Al-Moyed H, Chaieb L, Sarp L, Antal A, Paulus W: The fade-in–short stimulation–fade out approach to sham tDCS–reliable at 1 mA for naive and experienced subjects, but not investigators. Brain Stimul 2012, 5: 499–504.PubMed

120.

Nitsche MA, Fricke K, Henschke U, Schlitterlau A, Liebetanz D, Lang N, Henning S, Tergau F, Paulus W: Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J Physiol 2003, 553: 293–301.PubMedCentralPubMed

121.

Nitsche MA, Grundey J, Liebetanz D, Lang N, Tergau F, Paulus W: Catecholaminergic consolidation of motor cortical neuroplasticity in humans. Cereb Cortex 2004, 14: 1240–1245.PubMed

122.

Nitsche MA, Liebetanz D, Lang N, Antal A, Tergau F, Paulus W: Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 2003, 114: 2220–2222. author reply 2222–2223

123.

Barker AT, Jalinous R, Freeston IL: Non-invasive magnetic stimulation of human motor cortex. Lancet 1985, 1: 1106–7.PubMed

124.

Thickbroom GW: Transcranial magnetic stimulation and synaptic plasticity: experimental framework and human models. Exp Brain Res 2007, 180: 583–93.PubMed

125.

Martens JW, Koehler PJ, Vijselaar J: Magnetic flimmers: 'light in the electromagnetic darkness'. Brain 2013, 136: 971–9.PubMed

126.

Coppola G, Pierelli F, Schoenen J: Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia 2007, 27: 1427–39.PubMed

127.

Siniatchkin M, Sendacki M, Moeller F, et al.: Abnormal changes of synaptic excitability in migraine with aura. Cereb Cortex 2012, 22: 2207–16.PubMed

128.

Brighina F, Palermo A, Fierro B: Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine. J Headache Pain 2009, 10: 77–84.PubMedCentralPubMed

129.

Bernstein C, Burstein R: Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol 2012, 8: 89–99.PubMedCentralPubMed

130.

Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D: Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One 2008, 3: e3799.PubMedCentralPubMed

131.

Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Pearlman SH, Fischell RE, Ruppel PL, Goadsby PJ: Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol 2010, 9: 373–80.PubMed

132.

Brighina F, Piazza A, Vitello G, et al.: rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci 2004, 227: 67–71.PubMed

133.

Lorenz J, Minoshima S, Casey KL: Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 2003, 126: 1079–91.PubMed

134.

Misra UK, Kalita J, Tripathi GM, Bhoi SK: Is β endorphin related to migraine headache and its relief? Cephalalgia 2013,33(5):316–22.PubMed

135.

Zaghi S, Thiele B, Pimentel D: Assessment and treatment of pain with non-invasive cortical stimulation. Restor Neurol Neurosci 2011, 29: 439–51.PubMed

136.

Dodick DW, Schembri CT, Helmuth M, et al.: Transcranial magnetic stimulation for migraine: a safety review. Headache 2010, 50: 1153–63.PubMed

137.

Richards EM, Payne JL: The management of mood disorders in pregnancy: alternatives to antidepressants. CNS Spectr 2013 Apr, 10: 1–11.

138.

Brighina F, Palermo A, Daniele O, et al.: High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability? Cephalalgia 2010, 30: 46–52.PubMed

139.

Brighina F, Cosentino G, Vigneri S, Talamanca S, Palermo A, Giglia G, Fierro B: Abnormal facilitatory mechanisms in motor cortex of migraine with aura. Eur J Pain 2011, 15: 928–35.PubMed

140.

de Tommaso M, Stramaglia S, Brighina F, Fierro B, Francesco VD, Todarello O, Serpino C, Pellicoro M: Lack of effects of low frequency repetitive transcranial magnetic stimulation on alpha rhythm phase synchronization in migraine patients. Neurosci Lett 2011, 20: 143–7.

141.

Fumal A, Coppola G, Bohotin V, et al.: Induction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients. Cephalalgia 2006, 26: 143–149.PubMed

142.

de Tommaso M, Brighina F, Fierro B: Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine. J Headache Pain 2010, 11: 505–12.PubMedCentralPubMed

143.

Nnoaham KE, Kumbang J: Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev 2008,16(3):CD003222.

144.

Han JS, Chen XH, Sun SL, Xu XJ, Yuan Y, Yan SC, Hao JX, Terenius L: Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain 1991, 47: 295–8.PubMed

145.

Walsh DM, Howe TE, Johnson MI, Sluka KA: Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev 2009,15(2):CD006142.

146.

Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG: Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev 2012, 3: CD006276.PubMed

147.

Khadilkar A, Odebiyi DO, Brosseau L, Wells GA: Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain. Cochrane Database Syst Rev 2008,8(4):CD003008.

148.

Dubinsky RM, Miyasaki J: Assessment: efficacy of transcutaneous electric nerve stimulation in the treatment of pain in neurologic disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2010, 74: 173–6.PubMed

149.

Appenzeller O, Atkinson R: Transcutaneous nerve stimulation for the treatment of migraine and other head pain (author’s transl). MMW Munch Med Wochenschr 1975, 117: 1953–4.PubMed

150.

Solomon S, Guglielmo KM: Treatment of headache by transcutaneous electrical stimulation. Headache 1985, 25: 12–5.PubMed

151.

Bronfort G, Nilsson N, Haas M, Evans R, Goldsmith CH, Assendelft WJ, Bouter LM: Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database Syst Rev 2004,1(3):CD001878.

152.

Mousavi SA, Mirbod SM, Khorvash F: Comparison between efficacy of imipramine and transcutaneous electrical nerve stimulation in the prophylaxis of chronic tension-type headache: a randomized controlled clinical trial. J Res Med Sci 2011, 16: 923–27.PubMedCentralPubMed

153.

Schoenen J, Vandersmissen B, Jeangette S, Herroelen L, Vandenheede M, Gerard P, Magis D: Prevention of migraine by supraorbital transcutaneous neurostimulation using the Cefaly device (PREMICE): a multi-centre, randomized, sham-controlled trial. J Headache Pain 2013,1(Suppl 1):P184.

154.

Ellens DJ, Levy RM: Peripheral neuromodulation for migraine headache. Progress in neurological surgery 2011, 24: 109–117. doi: 10.1159/000323890PubMed

155.

Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR: Neurobiology of migraine. Neuroscience 2009, 161: 327–341. doi: 10.1016/j.neuroscience.2009.03.019PubMed

156.

Tomycz ND, Deibert CP, Moossy JJ: Cervicomedullary Junction Spinal Cord Stimulation for Head and Facial Pain. Headache: The Journal of Head and Face Pain 2011, 51: 418–425. doi: 10.1111/j.1526–4610.2010.01829.x

157.

Wolter T, Kiemen A, Kaube H: High cervical spinal cord stimulation for chronic cluster headache. Cephalalgia 2011,31(11):1170–1180. doi: 10.1177 /0333102411412627PubMed

158.

Gaul C, Jurgens T, May A: Concerning high cervical spinal cord stimulation for chronic cluster headache. Cephalalgia 2011,31(15):1588–1589. doi: 10.1177/0333102411422384PubMed

159.

Palmisani S, Al-Kaisy A, Arcioni R, Smith T, Negro A, Lambru G, Bandikatla V, Carson E, Martelletti P: A six year retrospective review of occipital nerve stimulation practice - controversies and challenges of an emerging technique for treating refractory headache syndromes. J Headache Pain 2013,14(1):67. doi: 10.1186/1129–2377–14–67PubMedCentralPubMed

160.

Goadsby P: Analysis of occipital nerve stimulation in studies of chronic migraine and broader implications of social media in clinical trials. Cephalalgia 2012, 33: 214–215.PubMed

Title: Neuromodulation of chronic headaches: position statement from the European Headache Federation
Authors: Paolo Martelletti
Rigmor H Jensen
Andrea Antal
Roberto Arcioni
Filippo Brighina
Marina de Tommaso
Angelo Franzini
Denys Fontaine
Max Heiland
Tim P Jürgens
Massimo Leone
Delphine Magis
Koen Paemeleire
Stefano Palmisani
Walter Paulus
Arne May
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/1129-2377-14-86

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Neuromodulation of chronic headaches: position statement from the European Headache Federation

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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