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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2019

Open Access 01-12-2019 | Migraine | Review

Role of single nucleotide polymorphisms (SNPs) in common migraine

Authors: Sukhvinder Kaur, Arif Ali, Uzair Ahmad, Yaser Siahbalaei, A. K. Pandey, Balkirat Singh

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2019

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Abstract

Single nucleotide polymorphisms (SNPs) may act as biological markers, as they can relate to the genes that are associated with various complex diseases such as heart diseases, diabetes, cancer, schizophrenia, blood pressure, migraine, and Alzheimer. These SNPs mostly locate within a gene or in a regulatory region near a gene and can affect the gene’s function to play a more direct role in disease. Hence, SNPs allow scientists to develop candidate drug therapy by evaluating an individual’s genetic makeup to develop a particular disease. Gene-gene interactions generally complicate migraine and its genetics and further gene-environmental interactions that often misguide the true defying causes of this disease. Due to its complex nature, it is difficult for scientists to reveal a complete list of SNPs or even all the genes that are related with the pathogenesis of this disease. Nowadays, much work has been done in this direction and new variants of migraine are being constantly identified. In this review article, the role of various SNPs reported to be disease-associated in published migraine GWAS has been discussed. To understand the molecular mechanisms of migraine attack by identifying new genetic variants of migraine can be a key to develop new therapeutic strategies in the future.
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Metadata
Title
Role of single nucleotide polymorphisms (SNPs) in common migraine
Authors
Sukhvinder Kaur
Arif Ali
Uzair Ahmad
Yaser Siahbalaei
A. K. Pandey
Balkirat Singh
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Keywords
Migraine
Aura
DOI
https://doi.org/10.1186/s41983-019-0093-8

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