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Maxillofacial Plastic and Reconstructive Surgery

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Open Access 01-12-2023 | Research

The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin

Authors: Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2023

Abstract

Background

Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.

Method

A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology.

Results

Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003).

Conclusion

Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.

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Title: The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
Authors: Ji Hae Lee
HaeYong Kweon
Ji-Hyeon Oh
Seong-Gon Kim
Publication date: 01-12-2023
Publisher: Springer Nature Singapore
Published in: Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2023
Electronic ISSN: 2288-8586
DOI: https://doi.org/10.1186/s40902-022-00368-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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Correction: MPRS Duplicated publication