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Molecular and Cellular Pediatrics

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Open Access 30-08-2023 | Bronchial Asthma | Review

Childhood asthma phenotypes and endotypes: a glance into the mosaic

Authors: Francesco Foppiano, Bianca Schaub

Published in: Molecular and Cellular Pediatrics | Issue 1/2023

Abstract

Background

Asthma is an inflammatory lung disease that constitutes the most common noncommunicable chronic disease in childhood. Childhood asthma shows large heterogeneity regarding onset of disease, symptoms, severity, prognosis, and response to therapy.

Main body

Evidence suggests that this variability is due to distinct pathophysiological mechanisms, which has led to an exhaustive research effort to understand and characterize these distinct entities currently designated as “endotypes.” Initially, studies focused on identifying specific groups using clinical variables yielding different “clinical phenotypes.” In addition, the identification of specific patterns based on inflammatory cell counts and cytokine data has resulted in “inflammatory endotypes.” More recently, an increasing number of molecular data from high-throughput technology (“omics” data) have allowed to investigate more complex “molecular endotypes.”

Conclusion

A better definition and comprehension of childhood asthma heterogeneity is key for improving diagnosis and treatment. This review aims at summarizing the current knowledge on this topic and discusses some limitations in their application as well as recommendations for future studies.

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Title: Childhood asthma phenotypes and endotypes: a glance into the mosaic
Authors: Francesco Foppiano
Bianca Schaub
Publication date: 30-08-2023
Publisher: Springer International Publishing
Keywords: Bronchial Asthma
Childhood Asthma
Published in: Molecular and Cellular Pediatrics / Issue 1/2023
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-023-00159-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Childhood asthma phenotypes and endotypes: a glance into the mosaic

Abstract

Background

Main body

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Main body

Conclusion

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