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Open Access 01-12-2016 | Mini review

Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development

Authors: Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci, Harald Ehrhardt

Published in: Molecular and Cellular Pediatrics | Issue 1/2016

Abstract

Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of abnormal somatic and psychomotor development. The contributors to this disease’s entity are multifactorial with pre- and postnatal origin. Central to the pathogenesis of bronchopulmonary is the induction of a massive pulmonary inflammatory response due to mechanical ventilation and oxygen toxicity. The extent of the pro-inflammatory reaction and the disturbance of further alveolar growth and vasculogenesis vary largely and can be modified by prenatal infections, antenatal steroids, and surfactant application.

This minireview summarizes the important recent research findings on the pulmonary inflammatory reaction obtained in patient cohorts and in experimental models. Unfortunately, recent changes in clinical practice based on these findings had only limited impact on the incidence of bronchopulmonary dysplasia.

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Title: Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development
Authors: Tayyab Shahzad
Sarah Radajewski
Cho-Ming Chao
Saverio Bellusci
Harald Ehrhardt
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2016
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-016-0051-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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