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Open Access 01-12-2015 | Review

The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases

Authors: Ines Mack, Andreas Hector, Marlene Ballbach, Julius Kohlhäufl, Katharina J Fuchs, Alexander Weber, Marcus A Mall, Dominik Hartl

Published in: Molecular and Cellular Pediatrics | Issue 1/2015

Abstract

Chitin, after cellulose, the second most abundant biopolymer on earth, is a key component of insects, fungi, and house-dust mites. Lower life forms are endowed with chitinases to defend themselves against chitin-bearing pathogens. Unexpectedly, humans were also found to express chitinases as well as chitinase-like proteins that modulate immune responses. Particularly, increased levels of the chitinase-like protein YKL-40 have been associated with severe asthma, cystic fibrosis, and other inflammatory disease conditions. Here, we summarize and discuss the potential role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases.

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Title: The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases
Authors: Ines Mack
Andreas Hector
Marlene Ballbach
Julius Kohlhäufl
Katharina J Fuchs
Alexander Weber
Marcus A Mall
Dominik Hartl
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2015
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-015-0014-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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