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Multidisciplinary Respiratory Medicine
Published in: Multidisciplinary Respiratory Medicine 1/2015

Open Access 01-12-2015 | Original research article

Nasal High-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report

Authors: Jens Bräunlich, Hans-Jürgen Seyfarth, Hubert Wirtz

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2015

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Abstract

Background

There are no data available about effectiveness of Nasal High-flow (NHF)in chronic respiratory insufficiency.

Methods

Eleven COPD patients with stable hypercapnia were adjusted to NHF-system with a flow of 20 l/min. After six weeks patients were switched to non-invasive ventilation (NIV) for another six weeks period.

Results

NHF led to significant decreases in resting pCO2. Between the devices we found no differences in pCO2 levels.

Conclusions

NHF may thus be an alternative treatment device in stable hypercapnic COPD patients.
Literature
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Windisch W, Brambring J, Budweiser S, Dellweg D, Geiseler J, Gerhard F, et al. Projektgruppe Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen Insuffizienz. [Non-invasive and invasive mechanical ventilation for treatment of chronic respiratory failure. [S2-Guidelines published by the German Medical Association of Pneumology and Ventilatory Support]. Pneumologie. 2010;64(4):207–40. doi:10.​1055/​s-0029-1243978. Epub 2010 Apr 7. Review.CrossRefPubMed
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Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014 Sep;2(9):698–705. doi: 10.​1016/​S2213-2600(14)70153-5. Epub 2014 Jul 24.
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Nava S, Navalesi P, Gregoretti C. Interfaces and humidification for noninvasive mechanical ventilation. Respir Care. 2009;54(1):71–84.PubMed
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Maggiore SM, Idone FA, Vaschetto R, Festa R, Cataldo A, Antonicelli F, et al. Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med. 2014;190(3):282–8. doi:10.​1164/​rccm.​201402-0364OC.CrossRefPubMed
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Stéphan F, Barrucand B, Petit P, Rézaiguia-Delclaux S, Médard A, Delannoy B, et al. High-Flow Nasal Oxygen vs Noninvasive Positive Airway Pressure in Hypoxemic Patients After Cardiothoracic Surgery: A Randomized Clinical Trial. JAMA. 2015;313(23):2331–9.CrossRefPubMed
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Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015;372(23):2185–96. doi:10.​1056/​NEJMoa1503326. Epub 2015 May 17.CrossRefPubMed
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Bräunlich J, Beyer D, Mai D, Hammerschmidt S, Seyfarth HJ, Wirtz H. Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients. Respiration. 2013;85(4):319–25. doi:10.​1159/​000342027. Epub 2012 Nov 1.CrossRefPubMed
8.
Metadata
Title
Nasal High-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report
Authors
Jens Bräunlich
Hans-Jürgen Seyfarth
Hubert Wirtz
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Multidisciplinary Respiratory Medicine / Issue 1/2015
Electronic ISSN: 2049-6958
DOI
https://doi.org/10.1186/s40248-015-0019-y

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