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Experimental Hematology & Oncology
Published in: Experimental Hematology & Oncology 1/2020

Open Access 01-12-2020 | Acute Myeloid Leukemia | Review

Clinical implications of recurrent gene mutations in acute myeloid leukemia

Authors: Jifeng Yu, Yingmei Li, Danfeng Zhang, Dingming Wan, Zhongxing Jiang

Published in: Experimental Hematology & Oncology | Issue 1/2020

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Abstract

Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy characterized by recurrent gene mutations. Genomic heterogeneity, patients’ individual variability, and recurrent gene mutations are the major obstacles among many factors that impact treatment efficacy of the AML patients. With the application of cost- and time-effective next-generation sequencing (NGS) technologies, an enormous diversity of genetic mutations has been identified. The recurrent gene mutations and their important roles in acute myeloid leukemia (AML) pathogenesis have been studied extensively. In this review, we summarize the recent development on the gene mutation in patients with AML.
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Metadata
Title
Clinical implications of recurrent gene mutations in acute myeloid leukemia
Authors
Jifeng Yu
Yingmei Li
Danfeng Zhang
Dingming Wan
Zhongxing Jiang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2020
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/s40164-020-00161-7

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