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Translational Neurodegeneration
Published in: Translational Neurodegeneration 1/2021

Open Access 01-12-2021 | Alzheimer's Disease | Review

Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Authors: Feng-Chen Bi, Xin-He Yang, Xiao-Yu Cheng, Wen-Bin Deng, Xiao-Li Guo, Hui Yang, Yin Wang, Juan Li, Yao Yao

Published in: Translational Neurodegeneration | Issue 1/2021

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to meet research needs for AD. However, recent three-dimensional (3D) cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD. In this review, we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models, and propose possible solutions, in order to improve their application in AD research. Ethical concerns associated with human cerebral organoids are also discussed. We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.
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Metadata
Title
Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research
Authors
Feng-Chen Bi
Xin-He Yang
Xiao-Yu Cheng
Wen-Bin Deng
Xiao-Li Guo
Hui Yang
Yin Wang
Juan Li
Yao Yao
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2021
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/s40035-021-00252-3

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