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Open Access 01-12-2023 | Dengue Virus | Research

Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Authors: Jih-Jin Tsai, Ko Chang, Chun-Hong Chen, Ching-Len Liao, Liang-Jen Chen, Yan-Yi Tsai, Ching-Yi Tsai, Ping-Chang Lin, Miao-Chen Hsu, Li-Teh Liu

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

Dengue virus serotype 2 (DENV-2) was the major serotype in the 2015 dengue outbreak in Taiwan, while DENV-1 and DENV-3 were dominant between 2005 and 2014. We aimed to investigate whether DENV-2 contributed to disease severity and mortality in the outbreak in Kaohsiung city, Taiwan.

Methods

We collected serum samples from dengue patients to detect the presence of DENV and determine the serotypes by using quantitative reverse transcription-polymerase chain reaction. Our cohorts comprised 105 DENV-1-infected cases and 1,550 DENV-2-infected cases. Demographic data, DENV serotype, and comorbidities were covariates for univariate and multivariate analyses to explore the association with severity and mortality.

Results

The results suggested that DENV-1 persisted and circulated, while DENV-2 was dominant during the dengue outbreak that occurred between September and December 2015. However, DENV-2 did not directly contribute to either severity or mortality. Aged patients and patients with diabetes mellitus (DM) or moderate to severe chronic kidney disease (CKD) had a higher risk of developing severe dengue. The mortality of dengue patients was related to a higher Charlson comorbidity index score and severe dengue. Among DENV-2-infected patients and older patients, preexisting anti-dengue IgG, DM, and moderate to severe CKD were associated with severe dengue. Moreover, female sex and severe dengue were associated with a significantly higher risk of death.

Conclusions

Our findings highlight the importance of timely serological testing in elderly patients to identify potential secondary infections and focus on the meticulous management of elderly patients with DM or moderate to severe CKD to reduce dengue-related death.

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Title: Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015
Authors: Jih-Jin Tsai
Ko Chang
Chun-Hong Chen
Ching-Len Liao
Liang-Jen Chen
Yan-Yi Tsai
Ching-Yi Tsai
Ping-Chang Lin
Miao-Chen Hsu
Li-Teh Liu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Dengue Virus
Chronic Kidney Disease
Diabetes
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01454-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dengue virus serotype did not contribute to clinical severity or mortality in Taiwan’s largest dengue outbreak in 2015

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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