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Archives of Public Health
Published in: Archives of Public Health 1/2023

Open Access 01-12-2023 | Dementia | Study Protocol

Feasibility of a community-adapted multi-domain intervention for dementia prevention among older adults: a research protocol

Authors: Yujiro Kuroda, Kosuke Fujita, Taiki Sugimoto, Kazuaki Uchida, Taichi Shimazu, Junko Saito, Hidenori Arai, Takashi Sakurai

Published in: Archives of Public Health | Issue 1/2023

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Abstract

Background

Multi-domain interventions effectively prevent dementia in clinical settings; however, their efficacy within local communities is unclear. This study assesses the feasibility of an adapted multi-domain intervention for dementia prevention in community-dwelling older adults.

Methods

The single-arm trial enrolls 60 participants from two Obu City communities, Japan. Primary outcome: participant retention in the adapted multi-domain intervention; secondary outcomes: health and implementation outcomes. Over 12 months, a team of researchers and public health nurse oversees the study in the first half, gradually shifting the management to public health nurses in the second half. Using the Framework for Reporting Adaptations and Modifications-Enhanced, the clinical programme is adjusted for the local community. It includes a 60-minute exercise and 30-minute group sessions, targeting lifestyle, diet, and social participation.

Discussion

This pioneer study evaluates the feasibility of an adapted intervention programme for dementia prevention in a community setting. Challenges in disseminating dementia prevention programmes warrant further investigation into effective implementation as well as strategies and methods to appeal to the target population. Upon confirming this programme’s feasibility, future studies can further evaluate its broader effectiveness.

Trial registration

The protocol is registered with the Clinical Trials Registry (UMIN-CTR) of the University Hospital’s Medical Information Network, under registration number UMIN000050581.
Literature
1.
Sleeman KE, de Brito M, Etkind S, Nkhoma K, Guo P, Higginson IJ The escalating global b1. Sleeman KE, de Brito M, Etkind S, Nkhoma K, Guo P, Higginson IJ et al. The escalating global burden of serious health-related suffering: projections to 2060 by world regions, age groups, and health conditions. Lancet Glob Health. 2019;7(7):e883–92.
2.
Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, et al. A two-decade comparison of prevalence of Dementia in individuals aged 65 years and older from three geographical areas of England: results of the cognitive function and ageing study I and II. Lancet. 2013;382(9902):1405–12.PubMedPubMedCentralCrossRef
3.
Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of Dementia over three decades in the Framingham Heart Study. N Engl J Med. 2016;374(6):523–32.PubMedPubMedCentralCrossRef
4.
Ding M, Qiu C, Rizzuto D, Grande G, Fratiglioni L. Tracing temporal trends in Dementia incidence over 25 years in central Stockholm, Sweden. Alzheimers Dement. 2020;16(5):770–8.PubMedCrossRef
5.
Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, et al. Trends in Dementia prevalence, incidence, and survival rate in a Japanese community. Neurology. 2017;88(20):1925–32.PubMedCrossRef
6.
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in Early Alzheimer’s Disease. N Engl J Med. 2023;388(1):9–21.PubMedCrossRef
7.
Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–63.PubMedCrossRef
8.
Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC, Harvey DJ, et al. Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization. Neurology. 2010;74(3):201–9.PubMedPubMedCentralCrossRef
9.
Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.PubMedCrossRef
10.
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46.PubMedPubMedCentralCrossRef
11.
Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, et al. World-wide FINGERS Network: a global approach to risk reduction and prevention of Dementia. Alzheimer’s & Dementia. 2020;16(7):1078–94.CrossRef
12.
Sugimoto T, Sakurai T, Akatsu H, Doi T, Fujiwara Y, Hirakawa A, et al. The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): the study protocol for an 18-Month, Multicenter, Randomized, Controlled Trial. J Prev Alzheimers Dis. 2021;8(4):465–76.PubMedPubMedCentral
13.
Purtle J, Peters R, Brownson RC. A review of policy dissemination and implementation research funded by the National Institutes of Health, 2007–2014. Implement Sci. 2016;11:1.PubMedPubMedCentralCrossRef
14.
Tinkle M, Kimball R, Haozous EA, Shuster G, Meize-Grochowski R. Dissemination and implementation research funded by the US National Institutes of Health, 2005–2012. Nurs Res Pract. 2013;2013:909606.PubMedPubMedCentral
15.
Aarons GA, Green AE, Palinkas LA, Self-Brown S, Whitaker DJ, Lutzker JR, et al. Dynamic adaptation process to implement an evidence-based child maltreatment intervention. Implement Sci. 2012;7:32.PubMedPubMedCentralCrossRef
16.
Chambers DA, Norton WE. The Adaptome: advancing the science of intervention adaptation. Am J Prev Med. 2016;51(4 Suppl 2):124–31.CrossRef
17.
Wiltsey Stirman S, Baumann AA, Miller CJ. The FRAME: an expanded framework for reporting adaptations and modifications to evidence-based interventions. Implement Sci. 2019;14(1):58.PubMedPubMedCentralCrossRef
18.
Marques L, Valentine SE, Kaysen D, Mackintosh MA, Dixon De Silva LE, Ahles EM, et al. Provider fidelity and modifications to cognitive processing therapy in a diverse community health clinic: associations with clinical change. J Consult Clin Psychol. 2019;87(4):357–69.PubMedPubMedCentralCrossRef
19.
Wiltsey Stirman S, Kimberly J, Cook N, Calloway A, Castro F, Charns M. The sustainability of new programs and innovations: a review of the empirical literature and recommendations for future research. Implement Sci. 2012;7:17.PubMedPubMedCentralCrossRef
20.
Bernal G, Jiménez-Chafey MI, Domenech Rodríguez MM. Cultural adaptation of treatments: a resource for considering culture in evidence-based practice. Prof Psychology: Res Pract. 2009;40:361–8.CrossRef
21.
Cabassa LJ, Baumann AA. A two-way street: bridging implementation science and cultural adaptations of mental health treatments. Implement Sci. 2013;8:90.PubMedPubMedCentralCrossRef
22.
23.
Fujiwara Y, Suzuki H, Yasunaga M, Sugiyama M, Ijuin M, Sakuma N, et al. Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatr Gerontol Int. 2010;10(3):225–32.PubMedCrossRef
24.
Tsutsui T, Muramatsu N. Care-needs certification in the long-term care insurance system of Japan. J Am Geriatr Soc. 2005;53(3):522–7.PubMedCrossRef
25.
Schulz KF, Altman DG, Moher D, Group CONSORT. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332.PubMedPubMedCentralCrossRef
26.
La Bash H, Thomas FC, Wiltsey-Stirman S. Adaptation of evidence-based interventions. Practical Implementation Science: Moving Evidence Into Action New York, NY: Springer.; 2022. pp. 73–96.
27.
Rouse HJ, Small BJ, Faust ME. Assessment of Cognitive Training & Social Interaction in people with mild to moderate Dementia: a pilot study. Clin Gerontologist. 2019;42(4):421–34.CrossRef
28.
Shimada H, Makizako H, Doi T, Park H, Tsutsumimoto K, Verghese J, et al. Effects of Combined Physical and Cognitive exercises on Cognition and mobility in patients with mild cognitive impairment: a Randomized Clinical Trial. J Am Med Dir Assoc. 2018;19(7):584–91.PubMedCrossRef
29.
Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Nofuji Y, et al. Association of Dietary Variety with body composition and physical function in community-dwelling Elderly Japanese. J Nutr Health Aging. 2016;20(7):691–6.PubMedCrossRef
30.
Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Nakamoto M, et al. Dietary diversity decreases the risk of cognitive decline among Japanese older adults. Geriatr Gerontol Int. 2017;17(6):937–44.PubMedCrossRef
31.
Shimada H, Lee S, Harada K, Bae S, Makino K, Chiba I, et al. Study protocol of a Comprehensive Activity Promotion Program for the Prevention of Dementia: a Randomized Controlled Trial Protocol. J Prev Alzheimers Dis. 2022;9(2):376–84.PubMedPubMedCentral
32.
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.PubMedCrossRef
33.
Suzuki H, Kawai H, Hirano H, Yoshida H, Ihara K, Kim H, et al. One-year change in the Japanese Version of the Montreal Cognitive Assessment Performance and related predictors in Community-Dwelling older adults. J Am Geriatr Soc. 2015;63(9):1874–9.PubMedCrossRef
34.
Iiboshi K, Yoshida K, Yamaoka Y, Eguchi Y, Sato D, Kishimoto M, et al. A validation study of the remotely administered Montreal Cognitive Assessment Tool in the Elderly Japanese Population. Telemed J E Health. 2020;26(7):920–8.PubMedCrossRef
35.
Prochaska JO, Velicer WF. The transtheoretical model of health behavior change. Am J Health Promot. 1997;12(1):38–48.PubMedCrossRef
36.
Kimura Y, Wada T, Ishine M, Ishimoto Y, Kasahara Y, Konno A, et al. Food diversity is closely associated with activities of daily living, depression, and quality of life in community-dwelling elderly people. J Am Geriatr Soc. 2009;57(5):922–4.PubMedCrossRef
37.
Kanamori S, Kai Y, Aida J, Kondo K, Kawachi I, Hirai H, et al. Social participation and the prevention of functional disability in older Japanese: the JAGES cohort study. PLoS ONE. 2014;9(6):e99638.PubMedPubMedCentralCrossRef
38.
Yamada M, Arai H. Predictive value of Frailty scores for Healthy Life Expectancy in Community-Dwelling older Japanese adults. J Am Med Dir Assoc. 2015;16(11):1002e7–11.CrossRef
39.
Kunz S. Psychometric properties of the EQ-5D in a study of people with mild to moderate Dementia. Qual Life Res. 2010;19(3):425–34.PubMedCrossRef
40.
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance Battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85–94.PubMedCrossRef
41.
Watanabe T, Owashi K, Kanauchi Y, Mura N, Takahara M, Ogino T. The short-term reliability of grip strength measurement and the effects of posture and grip span. J Hand Surg Am. 2005;30(3):603–9.PubMedCrossRef
42.
Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Ment Health. 2011;38(2):65–76.PubMedCrossRef
43.
Weiner BJ, Lewis CC, Stanick C, Powell BJ, Dorsey CN, Clary AS, et al. Psychometric assessment of three newly developed implementation outcome measures. Implement Sci. 2017;12(1):108.PubMedPubMedCentralCrossRef
44.
Dean N, Pagano M. Evaluating confidence interval methods for binomial proportions in clustered surveys. J Surv Stat Methodol. 2015;3(4):484–503.CrossRef
45.
Pembury Smith MQR, Ruxton GD. Effective use of the McNemar test. Behav Ecol Sociobiol. 2020;74(11):133.CrossRef
46.
Neuendorf KA. The content analysis guidebook. SAGE; 2017. p. 457.
47.
48.
National Academies of Sciences, Division E, Services H, on HC B, Policy B, on HS. Caregivers C on CI for I with D and T, Stroud C, MAKING DECISIONS ABOUT IMPLEMENTATION [Internet]. Meeting the Challenge of Caring for Persons Living with Dementia and Their Care Partners and Caregivers: A Way Forward. National Academies Press (US); 2021 [cited 2023 Mar 22]. Available from: https://​www.​ncbi.​nlm.​nih.​gov/​books/​NBK570078/​.
49.
Kulmala J, Rosenberg A, Ngandu T, Hemiö K, Tenkula T, Hyytiä A, et al. Facilitators and barriers to implementing lifestyle intervention programme to prevent cognitive decline. Eur J Public Health. 2021;31(4):816–22.PubMedPubMedCentralCrossRef
50.
Surr CA, Parveen S, Smith SJ, Drury M, Sass C, Burden S, et al. The barriers and facilitators to implementing Dementia education and training in health and social care services: a mixed-methods study. BMC Health Serv Res. 2020;20(1):512.PubMedPubMedCentralCrossRef
51.
Bartlett R, Milne R, Croucher R. Strategies to improve recruitment of people with Dementia to research studies. Dementia. 2019;18(7–8):2494–504.PubMedCrossRef
52.
Quiñones AR, Mitchell SL, Jackson JD, Aranda MP, Dilworth-Anderson P, McCarthy EP, et al. Achieving Health equity in embedded pragmatic trials for people living with Dementia and their family caregivers. J Am Geriatr Soc. 2020;68(S2):8–13.CrossRef
Metadata
Title
Feasibility of a community-adapted multi-domain intervention for dementia prevention among older adults: a research protocol
Authors
Yujiro Kuroda
Kosuke Fujita
Taiki Sugimoto
Kazuaki Uchida
Taichi Shimazu
Junko Saito
Hidenori Arai
Takashi Sakurai
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Archives of Public Health / Issue 1/2023
Electronic ISSN: 2049-3258
DOI
https://doi.org/10.1186/s13690-023-01205-0

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