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Annals of Intensive Care
Published in: Annals of Intensive Care 1/2019

Open Access 01-12-2019 | Care | Review

Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?

Authors: Virginie Lemiale, Anne-Pascale Meert, François Vincent, Michael Darmon, Philippe R. Bauer, Andry Van de Louw, Elie Azoulay, Groupe de Recherche en Reanimation Respiratoire du patient d’Onco-Hématologie (Grrr-OH)

Published in: Annals of Intensive Care | Issue 1/2019

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Abstract

Checkpoint protein inhibitor antibodies (CPI), including cytotoxic T-lymphocyte-associated antigen 4 inhibitors (ipilimumab, tremelimumab) and the programmed cell death protein 1 pathway/programmed cell death protein 1 ligand inhibitors (pembrolizumab, nivolumab, durvalumab, atezolizumab), have entered routine practice for the treatment of many cancers. They improve the outcome for many cancers, and more patients will be treated with CPI in the future. Although CPI can lead to adverse events (AE) less frequently than for chemotherapy, their use can require intensive care unit admission in case of severe immune-related adverse events (IrAE). Moreover, some of these events, particularly late events, are poorly documented, so a high level of suspicion should be maintained for patients receiving CPI. Intensivists should be aware in general of the known complications and appropriate management of these AE. Nevertheless, a multidisciplinary collaboration remains essential for their diagnosis and management. This review described the most severe complications related to CPI.
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Metadata
Title
Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?
Authors
Virginie Lemiale
Anne-Pascale Meert
François Vincent
Michael Darmon
Philippe R. Bauer
Andry Van de Louw
Elie Azoulay
Groupe de Recherche en Reanimation Respiratoire du patient d’Onco-Hématologie (Grrr-OH)
Publication date
01-12-2019
Publisher
Springer International Publishing
Keywords
Care
Hypophysitis
Published in
Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI
https://doi.org/10.1186/s13613-019-0487-x

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