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Open Access 01-12-2023 | Research

Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations

Authors: Shainey Alokit Khakha, Tintu Varghese, Sidhartha Giri, Alan Durbin, Gene S. Tan, Maheswari Kalaivanan, Jasmin Helan Prasad, Gagandeep Kang

Published in: Gut Pathogens | Issue 1/2023

Abstract

Rotaviruses (RVs) are the most common etiological agent of acute gastroenteritis among young children, even after vaccine introduction in low-income countries. A whole-genome classification representing the 11 RV genes, was introduced for surveillance and characterization of RVs. This study characterized the common circulating strains in Vellore, India from 2002 to 2017 to understand rotavirus strain diversity and evolution using Whole genome sequencing (WGS) carried out on Illumina MiSeq. The 89% (92% of Wa-like, 86% of DS-1-like) of strains had classical constellations, while reassortant constellations were seen in 11% (8% of Wa-like, 14% of DS-1-like) of the strains. The rare E6-NSP4 in combination with DS-1 like G1P[8] and the emergence of the OP-354 subtype of P[8] were identified. Phylogenetics of RV strains revealed multiple subtypes circulating in the past 15 years, with strong evidence of animal to human gene transmission among several strains.

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Title: Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic constellations
Authors: Shainey Alokit Khakha
Tintu Varghese
Sidhartha Giri
Alan Durbin
Gene S. Tan
Maheswari Kalaivanan
Jasmin Helan Prasad
Gagandeep Kang
Publication date: 01-12-2023
Publisher: BioMed Central
Published in: Gut Pathogens / Issue 1/2023
Electronic ISSN: 1757-4749
DOI: https://doi.org/10.1186/s13099-023-00569-6

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Obesity Clinical Trial Summary

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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